RI`GUI,ATION OF MYCOBAC t`IiRIAL
Transcripción
RI`GUI,ATION OF MYCOBAC t`IiRIAL
(1997) I n m u n o l o g i1a6 ,1 0 - 1 S RI'GUI,ATIONOF MYCOBACt'IiRIAL-I\DUCEDPROt\ILA}INIATORY CYTOKTNI'SI'CRETIONBY INTERLf,UKIN-;IIN RHEUMAIOID ARTHRITIS ind Xl,Ile.nandcT.(lr.rt P II6ndo7-Srmperio. A, Badill0-Iloret,\. Nunez'Vtzquez suLrir ip 'L 1tr !4sE9l:i!- rl-'p h Lriis{dy. $a Ddr rlr or lL rli pLodNfo, iducc digeN. rlr Dd€dyEd,ud llrp otudlLdio.ddKd kDiFch od Bcc indNedIL rD p oddo m I d$c tljgldnl'ib'ion (96 15%anJ 916%. €sp<r lelrl ind,lns rhirrroi ru\ firkd r ^hirrds! rL.rp Fdrb md'ftd riy nsobm FiiucomrLiL iprui.rhLr ri 16rde h n.r0 iidlud! r,ro poi .L L'cc. oDo pord lD r.dion n_ 0f!rc in oonrurar Dbyr muudirLtrs rr! dusr6d r chL.r0 h$ rLimdis EcioDd! ! rl.rp 10 Inmunologia16, l0-18 (1997) L0 i.ered by oorNdar.dLs tu n 'L rp p'odtrd0 (r!pr iroLukill !dlrc (iL l. hr lokm r (!r 2). hu0e r@nbn i^n'rudrul ,spoN* L,r-s5re'i)emE.q*tr L0(riil) rD'o, rrosn ntu.! ir\F o) rxi nd.ukrn 1rL6r b! liutrri uoroNL.tr clh i h iddion. sqc Rrcuoiud r[rN (r1A]r i (rs6rtr, Na.oMld.llgri.. a roNnrrioi or j [g]nL NiaEo).rrr r!\ u5!di hld dr Fdir0rddaory .r'okfs nrh is rr- p Dil iLil idulr Lb!sFsliod !r co. sr r-oris.Nr0) s.d r l . r r c l l r t r ' ! d ! s d r n ' i r l r i h r o i i m Ll L l i t ^n{ \6h6g !trr! li0.iil) trs. hned r RP\JI 16{0itrLrirDnpplnndr<i}th L.slmi! 12!,M) ] B r . r r i , ( 0 0u 6 r t . n 4 M i j . i r ( i hd midirrcd i56 . roLr0iiir) l,u suDrFd! riL.ip.I\! r odurft 'L ip pr.dtrddr of )\ori{rmr r'run |DNrc (Lorrnll imLrrd€d d rid $iu,I 11 Innunoloqia 16, 10-18{1997) 4 tL !P^ obn'Ltat .dk ltituka 'Lrll I (pc/mr) .rL ro'c driL [-rF leEh rd. .{L 'o rodDmd€ oolyDqints (10l]srdrL) r. siliiod *crctiddorn-'p \$ idukd wirh b ddanin. po$$icdirfcfN$ m rherL ' Df.diD br {ft dr' . rcLrlsorrL ilj Prcdulqr ofrL4 (10rghn). oLi rnonodonr bdcd i" rbeF;tN ulefki'i 1(2.!jn ) t, htrmin olibodr {irh Bcc nndi + SE\1rre 0 r r073 pgDL n=rr' aid r.lY) Hd'eR'. , rL 'ts pLodudioi IL r D &d rL 6 {sc qMiiicd bv Nng I mm' n.i inr b tL r9 fqdion br oomnr mmdNrer ,f rL LphdKd bv L.lporrrdr i6br f Dn 'L 6 f.mhnii buns lL l0 0' t.oDrrru r R*uLs !c erPrcr|d l9nl .ra* wft 0r otd md lj 70 p!mi. €+rirdv rt I tr!!s!ul rL I A! irLN d nfl!, d 'L 19F r'ior !!ih; n- , nhibtrioror ! '.17,i rn! dR&vr$ !rir rln lN1itrugi(r*.lN) P fL'€: rLrD pddNiior br nr-&hNci{r"adtstd :0 0i nmo bEr\ orrL lD $d. tus$tod bv ELrsA As \ho{i n 12 r-LL. P<00051Altl'oughrL ilj scrctror Dirmnthil,ibEd rL '0 prcdudi$bv drd,e mvo Inmunoloqia16, l0-18 (1997) ndd.edLipbyL{ d lhe ro-tD m B.:a.hdEedrL r0 pFddioi \ss dos*d.p.id.n1 fiq 2l r0 pshr redu.edrl,rp Fo,rEioD br ipprdmiidy j0 ruinL5uDDEsed rL lp produdio $ppmed nyobdiir-ji,rsed !_ r0 p'!d' dior ir x BCG ns@ ) n. hsw t tL.4 thdj tt /4[t,a !1 ]L ttt t4 d,htidlt PDrc t]t, 4, ht asd hwtr \tP h4t&&t h 4 1 ar qht dd6lq t tb \qr Rc. t5 leht) L! n ,, ^z ij tDe d "efr. .ltLr nr E4 eabh t5 kth, h h! b\!i? L*^.itt tlJ.{. rIlra h vt.nhts 6 Eust mhtuqn, rr!4hdin ttu hr tr !!h, 4dni-,,tLr Lt rt uy!turllt 4hn h r! t\!t! 1, "zQi..4^a u 4tu)t )1, t dtt tdtiv.. n||L oiLt p a.irii! Du F nu4t a. @. LI^r 6F'hter5 1D,4E whl 13 Inml'nologi.16,10n8 (1997) rabt 2 IL-t daa notrcnrc cetlriabili d|s(@!F"'s:{dbep Thesefindiur indi.aE d'!t the idhib or b@ra pnsdsively l*s wlb rine afrer*p.rn h b loo* ir soot c[s to mycobac€ial mfu*. ordd win BcG or ihe by hlllm monducler cdl! adined ha T{ell dennd cyrokine.m i'mmonodulat lhe l]-7GkDa.I!-l *s ,bl. io shdgly bl€k drn prdEtioo r ctrlM 1pFoddid4 ih. etrd ofrLz (50u/d) m rsEd on wiii rh. liehd bnibirion ocdns on d.y of nononucka e0s nom 3 indivi' (e6.15%iobibirionb BcGltinnlltd c'ntues or e2 6"n nydb,et,l'diwbd duls. n2 hd m silnficm' ef.ed dn n rp pmdudion id rh. 70'lDa snmdatd dltut. Tnis inhibiinhibitio! .hntr *hole brcilli (BcG) or a tr 40.90% iihibi by PBMC adiFed by rid m suftded oE rine ii@ 33% p poduc'im pmein, hy Bcc d d'. TGkDa do on n--l $pdiwly w ob*fled lfrtr 5 daysor cul@ lFis. J/. 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's n t Jm".,!.d.*,h',-"L,"".d"hbl-.-- €ir<tJt.pJ!d|)f,T(| rtpnJ It['le!rbLo( trioir L p lns mons "-;irL r0n,i,".^bvr''.".rr.i"L"d' i bnionwsc|artalvhe|mdcy'$\F€*po$Edrc oNposLbrcdplmdffid[s .""9"'|"m-,.d i".*...,rr^c mi u" a.-**u .,. r "i tr+ 'u*.a -o.puory n.t. rna.r" 'r'r *,i.t,. il[d L 0rofrdM ;'.-r"-d"',""' f,"1'Do*|LY0dN|ka$s..btde^dstdd$d iihiLiioi ofLPS iidudd rli0 prcddioi ri hmM rd fcsbn . r u c u h . r b \r L r n s i r n LI "-P'" hd; h "d,r,',. n""' r d; F,hvrys by snva Lh.en$ or hLm'n t(od E L r r 4 d L L .p p r c i u r i d e r ' o t u q r $ \ R4mrrv. !L r0 ed rcF p hNo bel ,[e,LsJf{o|ft€glLdbjllrh6he!d]I ; a " r* , 1 . ' a r * r d . , * c " . ' .H.d'"...d.. lL B rNFo r'd L 6'!rmo$d u".;..--*-' AXhotrsh I hs not vd rdmalied the p(d$ b..Jr -d -rhr*, F h r - ; n a t o ' r r t r ' o r ed i L r l ] u s' , ( n e i o ir d h e h 'r fe of rL !0 F! fi. mRNA 16 {r \4dd\tr me -r. mq]brcfu|rntretn'hJtLeojm|rdEdmrtrmJ L6 , rJrg trler frlrPft ";.0..."'" Innunologia 1 6 ,1 0 - 1 8{ 1 9 9 7 ) Nod!",on4rn,.ob4!ra.ndr"d L tb, Lr tdb}lljr!!!hDond'olr]orDmfu|ftbitrirj r0 amr! ^i. whor $. I sc. Kietr!o.((!Ll Drordr(h\r) 60 rrd ny.Dbud{ii 'j5 rDi h:p (u!. r : n o s sv . r , N U j o F . a r r z i p D l i l o u E . M n b u r i rinor (inrdlukr L) P.ol IT 16,10-18(1994 Inmunologla nenbryDNA0frhmsninbdeukiDlEeplol le.Mcln$e Kw, srepm Cr, r$li$ky (n, sdjmin vR, Pr@iflkrr. (lfi:li rr, cmpen c4 c.bizmib LA, Kjlbn PL. Innibitim orinbleukin I 0Ll): bid' diAgrnd biqcriviry id vih nd md'ndion or mt innalrfudo in vivo by ILI E.€phr dbspni* a dri-ILl recptu nonGlonal aiihody. I E p M.d 3r. dew$r-Mdelr r, Ab,ansJ, Bmd B, Iidss cG, de vrid rE Inhieukin l0 0L-10) i.nibia cr{okift sFrhesnby hmm noiocy8: m lurccd,bry rcle oflLloplodnc.dbymmoq{es.JExpM.d 12.Huis ED. nn@rbid rsJits: pri\ophynohgy nd inpli.rdm3 rd inenpy. lr.MiosecI Role ofi dLul]d I in sc p€rhosmeis ffntuits of rhdrbid 20.Lais c, Mui c. sbrs,{ MonGloml mhtodies Hdins si$ ihe inbkukin I E*pd d?frne! nulri. nolecul[ .ompl.i. Eu J Innml 1990i20:2m213. 34.Miyarra N, Slb ( coroM. AuellHEd inbleul<in21.Hd P I! viti Gr, Bug$s D& slity cA, Pieori etr(b vim or delmbid dbntis padaa: possibleinvol DS, Hmilm JH. Pobrirl diiifldmbry rneum nmi in joi d.sttrc'ion. Ailritb or inbnfl*jn 4: suppreeidnof h'lffi none]}€ fufi'.misfaddqirtibU}inl.mdprcsbglm. din 12. Pftc Nrd Asd s.i VSA 1e3ei361303-r307. ls.liF#in Gs, allm-cncia r, Mtll R Qmdhnre malysisor cltkid. ede *pEsion in Ihelmbid 2. Domelly RP, Fetrh Mt, Finbl@n Ds, c.mJd Tr. Di$ehlidteulldoioftr-lprcddioninhum 16 AMd N?, Day* J.Ci{okiG ,nd crtkine iobibibB nmocybbyFNg'om 23.I$M R, Rhoadd K McBride wH, Monon DL, linomsJs'n-.4domEgul&str..lmdnjF gere expEsion in hud mddocyd. J rmud 24.Domlly RP, Fetu Mi, l.rulnd rD, Ced,nl TL. Ir'l erprBsion in huhe miocrls b tudiptio ldly rnd pdtudipiimsly FenlrEd by tr--4. J 25.Tel velde A, Klohp r,Yfd B, Dc vris J, Fidsor, c.Modnhdonof phmt?ic ,ad ftndion l pqedi6 or hlllm periphdl blood mm.yts by IL-l. J L AdleEme induc* &l6riv. rfNA *pH:im of hdoc'{.m.didm'ndpstomr]meEns'JInmud 27.AEnd v", Jollin FG. nmp$n Rc. Hmm cH. Aninldleutjnliibibrfimhumnonoc,l*: pmtuchonud chlnr@izdim orbiolocr.,r pn:pd- ri*. rrmuor r939i14lrr35l-t3s3. 23'Navms,DebilN,Bm'udinJF,vaincbeokelw' foio.yls'Jllmuol1939!11243391345' DA, wou Itr Dodefry s, Mccftey-Fmds N, wa LM, EuingssorhL, Sd\midr JA, H3ll q Rob.tu An. Spon r!s. rtrfddng sneih fatu p is r pod inmmNpb pnliftrdio. I Imruol l933jr40102c1032. 30 cndry D, T'lffi ' Modul'rion or clbkire pDddion by tushidg snrin L6Fp. J lrmunol 1939;la2:4295-130o. 1a