MAY - North American Menopause Society

Menopause
The Journal of The North American Menopause Society
VOLUME 21, ISSUE 5, 2014
Supplemental Digital Content is available in the text.
C ONTENTS
Editorials
435
Ovary and unilateral oophorectomy: is having one the same as having two?
Douglas N. Brown, MD, FACOG, FACS
437
Vagina dialogues
Caroline M. Mitchell, MD, MPH, and Susan D. Reed, MD, MPH
439
Hormone therapy and vasomotor symptoms after the Women’s Health Initiative
Sybil L. Crawford, PhD
Original Articles
442
Incidence, time trends, laterality, indications, and pathological findings of
unilateral oophorectomy before menopause
Shannon K. Laughlin-Tommaso, MD, MPH, Elizabeth A. Stewart, MD,
Brandon R. Grossardt, MS, Liliana Gazzuola Rocca, MD,
and Walter A. Rocca, MD, MPH
Unilateral oophorectomy without a medical indication has been more common on the
left side because of surgical preferences and traditions. The long-term consequences of
right or left unilateral oophorectomy on timing of menopause, morbidity, and mortality
need further study.
(continued)
Menopause: The Journal of The North American Menopause Society (ISSN 1072-3714) is published monthly for The North American
Menopause Society by Lippincott Williams & Wilkins, 16522 Hunters Green Parkway, Hagerstown, MD 21740-2116. Business and production offices
are located at Two Commerce Square, 2001 Market St., Philadelphia, PA 19103. All rights reserved. Printed on acid-free paper. Periodical postage paid
at Hagerstown, Maryland, and at additional mailing offices. Copyright * 2014 by The North American Menopause Society.
POSTMASTER: Send address changes to Menopause: The Journal of The North American Menopause Society, P.O. Box 1550, Hagerstown, MD
21740.
C ONTENTS
(continued)
450
Association between the vaginal microbiota, menopause status,
and signs of vulvovaginal atrophy
Rebecca M. Brotman, PhD, MPH, Michelle D. Shardell, PhD, Pawel Gajer, PhD,
Doug Fadrosh, MS, Kathryn Chang, RN, Michelle I. Silver, ScM,
Raphael P. Viscidi, MD, Anne E. Burke, MD, MPH, Jacques Ravel, PhD,
and Patti E. Gravitt, PhD, MS
In a cross-sectional study of 87 pre-, peri- and post-menopausal women, a distinct
bacterial community state type (termed CST IV-A) with low relative abundance of
Lactobacillus spp. was found to be associated with both menopause stage and
vulvovaginal atrophy.
459
Use and discontinued use of menopausal hormone therapy by healthy women in
Norway: the Hordaland Women’s Cohort study
BjLrn Espen Gjelsvik, MD, JLrund Straand, MD, PhD, Steinar Hunskaar, MD, PhD,
Ingvild Dalen, PhD, and Elin O. Rosvold, MD, PhD
The 2-year incidence of hormone therapy (HT) users has been shown to have
decreased by almost 50% after 2002 and symptoms reappear in most women
after HT cessation.
469
Validation of the Quality of Life Questionnaire of the European Foundation for
Osteoporosis-31 in Spanish postmenopausal women
Pedro José González Matarı́n, MHS, Antonio Martı́nez-Amat, PhD,
Rafael Lomas-Vega, PhD, Nicolás Mendoza Ladrón de Guevara, MD,
Esther Dı́az-Mohedo, PhD, Emilio Martı́nez López, PhD,
Ana Belén Padial Garcı́a, BS, and Fidel Hita-Contreras, MD
The article presents the Spanish version of the QUALEFFO-31 questionnaire, which
has shown high reliability and validity for assessing quality of life in the Spanish
postmenopausal population.
477
Does hormone therapy affect blood pressure changes in the
Diabetes Prevention Program?
Catherine Kim, MD, MPH, Sherita H. Golden, MD, MHS, Shengchun Kong, MS,
Bin Nan, PhD, Kieren J. Mather, MD, Elizabeth Barrett-Connor, MD,
and Diabetes Prevention Program Research Group
In this study reductions in weight through lifestyle changes led to slight but
significant reductions in blood pressure compared to placebo. Decreases in blood
pressure were observed in women using estrogen therapy as well as in women not
using estrogen therapy.
C ONTENTS
(continued)
484
Safety of veralipride for the treatment of vasomotor symptoms of menopause
Marcelino Hernández Valencia, MD, PhD, Marı́a de Jesús Vega Arias, MD,
Cuauhtémoc Celis González, MD, Imelda Hernández Marı́n, MD,
Juan Humberto Martı́n González, MD, Enrique Rafael Morcate Campos, MD,
Marı́a Antonia Basavilvazo Rodrı́guez, MD, Ignacio Morales Álvarez, MD,
Marı́a Antonia Valdés Vargas, MD, José Braulio Everardo Otero Flores, MD,
Samuel Santoyo Haro, MD, Manuel Cortes Bonilla, MD,
Roberto Bernardo Escudero, MD, and Rosalba Alonso Campero, MD
The safety profile of veralipride for the treatment of vasomotor symptoms is discussed.
493
Melatonin in perimenopausal and postmenopausal women: associations with
mood, sleep, climacteric symptoms, and quality of life
Elena Toffol, MD, Nea Kalleinen, MD, PhD, Jari Haukka, PhD, Olli Vakkuri, PhD,
Timo Partonen, MD, PhD, and Päivi Polo-Kantola, MD, PhD
In this study postmenopausal women had lower nighttime serum melatonin
concentrations than perimenopausal women.
501
Does bone loss begin after weight loss ends? Results 2 years after weight loss or
regain in postmenopausal women
Nancy L. Von Thun, MS, Deeptha Sukumar, PhD, Steven B. Heymsfield, MD,
and Sue A. Shapses, PhD
Weight regain does not result in recovery of bone loss that occurs with
weight reduction.
509
Utility of obesity indices in screening Chinese postmenopausal women for
metabolic syndrome
Pengju Liu, BM, Fang Ma, MS, Huiping Lou, MS, and Yanning Zhu, MD
Although a variety of indices have been used to assess obesity, which is closely
associated with the presence of metabolic syndrome, it is suggested that waist-to-hip
ratio and waist-to-height ratio are the best indicators for predicting the presence of
metabolic syndrome in Chinese postmenopausal women.
515
Association of GALNT3 gene polymorphisms with bone mineral density in
Chinese postmenopausal women: the Peking Vertebral Fracture study
Nan Li, MD, Xiran Wang, MD, Yan Jiang, MD, Wenbo Wang, MD,
Wei Huang, MD, Xin Zheng, MD, Qiuping Wang, MD, Zhiwei Ning, MD,
Yu Pei, MD, Chunlin Li, MD, Min Nie, MD, Mei Li, MD, Ou Wang, MD,
Xiaoping Xing, MD, Shuli He, MD, Wei Yu, MD, Qiang Lin, MD, Ling Xu, MD,
and Weibo Xia, MD
GALNT3 gene polymorphisms were found in the present study to be associated with
the bone mineral density of Chinese postmenopausal women. GALNT3 may play a
role in genetic susceptibility to osteoporosis.
C ONTENTS
(continued)
522
Genome-wide association studies and epistasis analyses of candidate genes related
to age at menarche and age at natural menopause in a Korean population
Jung-A. Pyun, MS, Sunshin Kim, PhD, Nam H. Cho, PhD, InSong Koh, MD, PhD,
Jong-Young Lee, PhD, Chol Shin, MD, PhD, and KyuBum Kwack, PhD
Genome-wide association studies and epistasis analyses in a Korean population
identified that novel polymorphisms and synergistic interactions between candidate
genes were significantly associated with age at menarche and age at natural
menopause.
Brief Report
530
Polymorphisms within the FANCA gene associate with premature ovarian
failure in Korean women
Jung-A. Pyun, MS, Sunshin Kim, PhD, Dong Hyun Cha, MD, PhD,
and KyuBum Kwack, PhD
Genetic variations within Fanconi anemia complementation group A gene were
significantly associated with increased risk of premature ovarian failure in
Korean women.
Clinical Corner
Clinical Article
534
Menopause and sleep
Robert R. Freedman, PhD
Patient Handout
e3
What Midlife Women Should Know About Menopause and Sleep
Review Article
536
Critical review of complementary and alternative medicine use in menopause:
focus on prevalence, motivation, decision-making, and communication
Wenbo Peng, MMed, Jon Adams, PhD, David W. Sibbritt, PhD,
and Jane E. Frawley, MClinSci
A review of the prevalence of complimentary and alternative medicine (CAM) use for
menopause alongside CAM user’s characteristics, motivations, decision making and
communication with healthcare providers.
Letters to the Editor
549
C ONTENTS
(continued)
Erratum
550
Urine melatonin levels are inversely associated with sarcopenia in
postmenopausal women: Erratum
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