Spanish Red Biotech Pipeline*

Spanish Red Biotech Pipeline
Spanish Red Biotech Pipeline 2013
*
DRU G S: NA TI O NA L CO M P A N I E S
Cancer 34%
Autoimmune and Inflammation 5%
Central Nervous System 18%
Blood and Lymphatic systems 3%
Infections 7%
Muskuloskeletal Disorders 3%
Cardiovascular and circulatory systems 4%
Kidney and Genitourinary system 2%
Ophtalmology and Optometry 7%
Dermatology 5%
Digestive System 3%
Respiratory and Pulmonary system 2%
Genetic Diseases and Dysmorphic
Metabolic / Endocrinology 1%
syndromes 6%
OT H ER TE CHNO L O G I E S
Metabolic/
Endocrinology 5%
Infections 5%
Muskuloskeletal
Disorders 28%
Wome’s health 5%
Kidney and
Genitourinary
system
5%
Others 9%
DRUGS: NATIONAL COMPANIES
Non Regulatory
Preclinical
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Regulatory
Preclinical
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Company
Product
Type
Therapeutic area
Indication
GP-Pharm
GP-Pharm
PharmaMar
PharmaMar
PRAXIS
FERRER
FUNDACIÓN PROGRESO Y SALUD (Servicio Andaluz de Salud)
GP-Pharm
PharmaMar
PharmaMar
Advancell
Advancell
Advancell
Advancell
Archivel Farma
DIGNA Biotech
DIGNA Biotech
ESTEVE
ESTEVE
FERRER
Lutrate Depot 3,75 mg
Desmopresina Solución
Yondelis
Yondelis
EPIPROT/HEBERPROT
Ozenoxacin
IMABIS-78
Lutrate Depot 22,5 mg
Yondelis
Aplidin
ATH001 (Acadra)
ATH001 (Acadra)
ATH008
ATH012
RUTI®
P144 (Disitertide)
IFNa5
E-58425
E-52862
Lorediplon
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Vaccines
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Cancer
Kidney and Genitourinary system
Cancer
Cancer
Dermatology
Infections
Central Nervous System
Cancer
Cancer
Cancer
Cancer
Cancer
Cancer
Central Nervous System
Infections
Genetic Diseases and Dysmorphic syndromes
Infections
Central Nervous System
Central Nervous System
Central Nervous System
FUNDACIÓN PROGRESO Y SALUD / IATA (Servicio Andaluz de Salud)
Autologous Bone Marrow Mononuclear cells
Gene / Cell Therapy
Cardiovascular and circulatory systems
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Europe
FUNDACIÓN PROGRESO Y SALUD / IATA (Servicio Andaluz de Salud)
Autologous Bone Marrow Mononuclear cells and Adipose Mesenchymal stem cells
Autologous Bone Marrow progenitors, Adipose Mesenchymal stem cells and
Bone Marrow Mesenchymal Stem Cells
Engineered Corneas
Allogeneic Adipose Mesenchymal stem cells / Allodepleted Bone Marrow Progenitors
FIBAO-91
Octeotride LAR
NT-KO-003
Dersalazine sodium
Albaconazole
Zalipsis
PM01183
PM01183
PM01183
PM01183
PM01183
EPIPROT
SOM-0226
SYL040012
SYL1001
TT-173
ABTL0812
Lentiviral vector - FANCA gene
P144 (Disitertide)
CT-1
CT-1
CT-1
Vector AAV-gen de porfiria
P144 (Disitertide)
HIVACAT
Autologous Bone Marrow Mononuclear cells
Pegylated Liposomes for Oncology
Lutrate Depot 45 mg
Octeotride MAR
Triptorelina Depot 1-3
ory-1001
UR-63325 (Histamine H4 receptor antagonist)
UR-13870 (p38 MAP Kinase Inhibitor)
PM01183
PM060184
SNF-472
SOM9025
SOM-0606
ABTL1014
ABvac40
IB10C179
IB10A111
IB12A157
BNT-001
BO-110
BN201
BN201
Ctx101
EDA-HPVE7
EC-70124 iv
EC-70124 po
EC-8105 iv
EC-8042 iv
Vector AAV-sulfamidase gene
Anti-CN
p38
p300
H.pylori
Cysteine P.
Malaria
TTC-ELA
FIB-111
FIB-112
FIB-114
FIB-116
FIB-117
EDA-HPVE7
Risperidona Depot
HR004
HR002
HR010
HR017
IND-OO6
LP226A1
NST0037
NST0060
ORY-2001
PEV pept. 01-02
PROHEAL
Fibrodress
TERFIQEC
PRO-001
DUPUYGEL
IFN-alpha 2b
IFN-beta 1b
Filgrastin G-CSF
SNF-471
SNF-571
SOM-0558
Gene / Cell Therapy
Digestive System
Prostate Cancer
Nocturnal Enuresis
Soft tissue sarcomas
Platinum-sensitive relapsed ovarian cancer
Diabetic Foot
Dermal infections
X-Fragil
Prostate Cancer
Soft Tissue Sarcoma related to Translocations
Multiple Myeloma
B cell Chronic Lymphocytic Leukemia
Myelodisplastic Syndromes
Palmar-Plantar erythrodysesthesia and Hand-Foot Skin Reaction
Multiple Sclerosis
Therapeutic vaccine: Active tuberculosis - Latent Tuberculosis
Cutaneous manifestations of Systemic Sclerosis and Morphea (Schlerodermia)
Hepatitis C
Pain treatment
Neuropathic Pain
Sleep disorders
Acute Miocardial Infarction / Dilated Miocardiopathy / Chronic Ischemic Cardiopathy /
Critical Limb Ischemia in diabetic patients, in non diabetic patients
Extended Liver resection / Faecal Incontinence
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Europe
Gene / Cell Therapy
Central Nervous System
Stroke / Multiple Sclerosis and ALS
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Europe
Gene / Cell Therapy
Gene / Cell Therapy
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Gene / Cell Therapy
Biodrugs
Biodrugs
Gene / Cell Therapy
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Gene / Cell Therapy
Vaccines
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Vaccines
Gene / Cell Therapy
Gene / Cell Therapy
Gene / Cell Therapy
Gene / Cell Therapy
Gene / Cell Therapy
Gene / Cell Therapy
Vaccines
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Gene/Cell Therapy
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Gene / Cell Therapy
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Ophthalmology and optometry
Blood and Lymphatic systems
Autoimmune & Inflammation
Cancer
Central Nervous System
Autoimmune & Inflammation
Infections
Cancer
Cancer
Cancer
Cancer
Cancer
Cancer
Dermatology
Central Nervous System
Ophthalmology and optometry
Ophthalmology and optometry
Blood and Lymphatic systems
Cancer
Genetic Diseases and Dysmorphic syndromes
Cancer
Genetic Diseases and Dysmorphic syndromes
Digestive System
Kidney and Genitourinary system
Genetic Diseases and Dysmorphic syndromes
Cancer
Infections
Cardiovascular and circulatory systems
Cancer
Cancer
Cancer
Cancer
Cancer
Respiratory and Pulmonary system
Autoimmune & Inflammation
Cancer
Cancer
Cardiovascular and circulatory systems
Central Nervous System
Dermatology
Cancer
Central Nervous System
Central Nervous System
Cancer
Cancer and Ophtalmology
Genetic Diseases and Dysmorphic syndromes
Cancer
Central Nervous System
Central Nervous System and Ophthalmology
Cardiovascular and circulatory systems
Cancer
Cancer
Cancer
Cancer
Cancer
Genetic Diseases and Dysmorphic syndromes
Autoimmune & Inflammation
Central Nervous System
Cancer
Infections
Infections
Infections
Cancer
Ophthalmology and optometry
Ophthalmology and optometry
Blood and Lymphatic systems
Dermatology
Cancer
Cancer
Central Nervous System
Muskuloskeletal Disorders
Muskuloskeletal Disorders
Central Nervous System
Respiratory and Pulmonary system
Autoimmune & Inflammation
Central Nervous System
Central Nervous System
Central Nervous System
Central Nervous System
Metabolic / Endocrinology
Dermatology
Dermatology
Genetic Diseases and Dysmorphic syndromes
Ophthalmology and optometry
Muskuloskeletal Disorders
Infections
Central Nervous System
Cancer
Cardiovascular and circulatory systems
Kidney and Genitourinary system
Cancer
Autoimmune & Inflammation/ Digestive System
Ophthalmology and optometry
Muskuloskeletal Disorders
Central Nervous System
Blood and Lymphatic systems
Corneal ulcers
Chronic Graft versus Host Disease / Hematological Malignancies
Sepsis
Acromegaly
Multiple Sclerosis
Ulcerative Colitis
Fungal Infections
Multiple Myeloma
Breast cancer
Platinum-resistant ovarian cancer
Pancreatic cancer
Lung cancer
Combination trials
Diabetic Foot
Polineuropatia Amiloidótica Familiar
Ocular Hypertension / Glaucoma
Dry eye Syndrome
Hemorrhage
Lung and Pancreatic Cancer
Fanconi Anaemia-A (FANCA)
Skin Cancer
Ischemia / Reperfusion Injury in renal transplant
Post-hepatectomy liver failure in cancer patients
Acute Kidney Injury in cardiac surgery
Acute Intermittent Porphyria
Actinic Keratosis
Prophylactic- Therapeutic HIV vaccine
Critical Limb Ischemia in diabetic patients
Advanced Ovarian Cancer / Advanced Breast Cancer
Prostate Cancer
Acute diarrhea post chemotherapy
Prostate Cancer
Acute Leukemia
Asthma and allergic rhinitis
Inflammatory and Autoimmune diseases
Acute leukaemia
Solid tumours
Cardiovascular disease
Enfermedad de Huntington
Psoriasis
Leukemia and Lymphomas
Alzheimer’s Disease
Alzheimer’s Disease
Glioblastoma
Angiogenesis inhibitor
Lysosomal storage diseases
Melanoma, breast cancer, glioblastoma, bladder and pancreatic carcinoma
Multiple Sclerosis and Acute Optic Neuritis
Glaucoma
Miocardial regeneration based on Cardiac Stem Cells (CSC)
Therapeutic vaccine
Solid and hematological tumors
Solid tumors
EWS
Solid Tumors
Lisosomal storage rare disease
Rheumatoid Arthritis and Atherosclerosis
Neuropathic Pain
Cancer
H. pylori
Malaria & Trypanosomiasis
Malaria
ALS
Macular degeneration
Corneal reconstruction
Non Hodkin Lymphoma
Psoriasis
Spinal Cord Injury
Cervical cancer
Schizophrenia
Bone Regeneration
Joint Regeneration
Neuroprotection & repair
Idiopathic Pulmonary Fibrosis
Treatment and Prophylaxis of acute and multi-resistant bacterial infections
Alzheimer’s Disease
Neuroprotection
Neuroprotection
Huntington Disease / Alzheimer’s disease
Metabolic Syndrome
Diabetic / vascular
Diabetic / vascular
Cytic Fibrosis
Retinitis Pigmentosa
Dupuytren’s Contracture
Hepatitis C
Multiple Sclerosis
Leukemia
Cardiovascular disease
Calcic Renal Lithiasis
T-Cell Lynphoma
Crohn’s disease and ulcerative colitis
Diabetic Retinopathy
Myotonic Dystrophy
Multiple Sclerosis
Non Hodkin Lymphoma
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Europe
Europe
FUNDACIÓN PROGRESO Y SALUD / IATA (Servicio Andaluz de Salud)
FUNDACIÓN PROGRESO Y SALUD / IATA (Servicio Andaluz de Salud)
FUNDACIÓN PROGRESO Y SALUD / IATA (Servicio Andaluz de Salud)
FUNDACIÓN PROGRESO Y SALUD (Servicio Andaluz de Salud)
GP-Pharm
Neurotec Pharma
Palau Pharma
Palau Pharma
PharmaMar
PharmaMar
PharmaMar
PharmaMar
PharmaMar
PharmaMar
PRAXIS
SOM Biotech
Sylentis
Sylentis
Thrombotargets
Ability Pharmaceuticals
CIBERER
DIGNA Biotech
DIGNA Biotech
DIGNA Biotech
DIGNA Biotech
DIGNA Biotech
DIGNA Biotech
ESTEVE
FUNDACIÓN PROGRESO Y SALUD / IATA (Servicio Andaluz de Salud)
GP-Pharm
GP-Pharm
GP-Pharm
GP-Pharm
Oryzon
Palau Pharma
Palau Pharma
PharmaMar
PharmaMar
Sanifit
SOM Biotech
SOM Biotech
Ability Pharmaceuticals
Araclon Biotech
Biomar
Biomar
Biomar
Bionaturis
Bioncotech Therapeutics
Bionure
Bionure
Coretherapix
DIGNA Biotech
EntreChem
EntreChem
EntreChem
EntreChem
ESTEVE
FECYT
FECYT
FECYT
FECYT
FECYT
FECYT
FERRER
FERRER
FERRER
FERRER
FERRER
FERRER
Formune SL
GP-Pharm
Histocell
Histocell
Histocell
Histocell
ImmunNovative Developments
Lipopharma Therapeutics
Neuron Bio
Neuron Bio
Oryzon
Pevesa
PRAXIS
PRAXIS
PRAXIS
ProRetina Therapeutics
PROTEOS Biotech
PROTEOS Biotech
PROTEOS Biotech
PROTEOS Biotech
Sanifit
Sanifit
SOM Biotech
Sylentis
TERACLON
Valentia Biopharma
Vivacell Biotechnology España
Vivia Biotech
V1932
VLT 002
VCE-003
Vivia 009
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Phase I
Phase II
Phase III
Ready to Market
Studies Location
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Worldwide
Europe (Pending aproval)
Latinamerica
Europe
USA
Worldwide
Worldwide
Worldwide
Europe
Europe
Europe
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Europe and Southafrica
Europe
Europe
Europe
Europe
Europe
Europe
Europe
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Worldwide
Worldwide
Worldwide
Worldwide
Worldwide
Worldwide
Worldwide
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Worldwide
Europe, USA
Worldwide
Worldwide
Worldwide
Worldwide
Europe, Latinamerica
Worldwide
Europe
Europe
Europe
Europe
Worldwide
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
USA
Europe
Worldwide
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Worldwide
Europe
Europe, USA, Canada, Japan
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Worldwide
Europe & México
Europe
Europe
RESEARCH PLATFORMS
Ophthalmology
and optometry
19%
Dermatology 24%
www.asebio.com
Spanish Bioindustry Association
ASEBIO, the Spanish Bioindustry Association, encompasses over 230 firms, associations, foundations, universities, technology and
research centers which carry out activities directly or indirectly related to biotechnology.
The wide number of associates makes ASEBIO the most appropriate meeting platform to face up the challenges of developing the
biotechnology sector in Spain.
Around 600 companies research and develop products in the Spanish biotechnology sector.
Company
Biomar
Bionaturis
CIBERER
FUNDACIÓN PROGRESO Y SALUD (BIONAD)
Histocell
IMEGEN
Ingeniatrics
OWL
Type
Enabling Technologies
CRO
Enabling Technologies
CRO
Enabling Technologies
Screening
Enabling Technologies
Enabling Technologies
Bioftalmik Applied Research
Drug Delivery
BIOMOL-INFORMATICS
CIBERER
Lipopharma Therapeutics
SISTEMAS GENÓMICOS
SISTEMAS GENÓMICOS
PROTEOS Biotech
Biomar
CIBERER
Fundacion MEDINA
GH Genhelix
Ingeniatrics
Ingeniatrics
CIBER-BBN
CIBER-BBN
CIBER-BBN
CIBER-BBN
CIBER-BBN
CIBERER
Fundacion MEDINA
FUNDACIÓN PROGRESO Y SALUD (BIONAND)
FUNDACIÓN PROGRESO Y SALUD (CABIMER)
FUNDACIÓN PROGRESO Y SALUD (CABIMER)
IMEGEN
Inbiomed
Integromics
Plebiotic
Screening
Screening
Enabling Technologies
Screening
Screening
CRO
Screening
Enabling Technologies
Screening
CRO
Drug Delivery
Screening
Enabling Technologies
Drug Delivery
Enabling Technologies
Enabling Technologies
Enabling Technologies
Others
Enabling Technologies
Drug Delivery
Enabling Technologies
CRO
Screening
Screening
Screening
Screening
Description
Contract manufacturing: upstream and downstream development, analytical development, scale-up
Development and manufacturing of recombinant proteins by means of FLYLIFE technology
Centro Nacional de Genotipado(CeGen-ISCIII) Genotyping services
Genomics and Bioinformatic Platform of Andalusia / NANOIMAGING & METABOLOMIC PLATFORM / ANDALUSIAN BIOBANK
Cell shipping medium. To develop ready-to-use cell based models for research
Sequence Capture; Genetic Diseases and Dysmorphic syndromes;Exome Analysis, Genomics
Absolute Count of cells using flow cytometry
Lipidomics Platform
Lipid nanoparticles / sustained drug delivery for ocular surface pathologies. Ocular surface pathologies ( Inflammation, Dry Eye, Blaepharitis, Ocular Allergy…).
Treatment for Inflammation, Dry Eye, Blaepharitis, Ocular Allergy
Whole human exome sequencing: identification of new candidate genes for rare diseases
PROTEOmAb: Protein array technology to analyze energy metabolism
A novel therapeutic approach: Membrane Lipid Therapy (MLT)
Pharmacogenomics. Markers of drug response
Whole exome resequencing in humans permits the identification of the new genes associated with both rare and common diseases
Creation and qualification of cell banks: MCB and WCB
Marine Natural Products library
BIER: BioInformatic Platform for Rare Diseases
High throughput screening platform for drug discovery
GHL - CCUL. Microbial and Mammalian cell culturing
Platform for coating of Medical Devices. Odontology
Platform for high through put analysis of microorganisms.Accelerated diagnosis of bacterial diseases. Several
BBN-BIOMOL. Design and “a la carte” production of Biomolecules (Proteins, Antibodies and Peptides)
BBN Nanoconjugates. Drug delivery
BBN-Protein. Protein production
BBN-Peptide. Synthesis of peptide
BBN-Ab. Antibody production
SEFALer: phenotyping of animal models with specific application for rare diseases
Mass spectrometry metabolomics
Liposome delivery System (Prostate Cancer)
Hibridome/Antibody Production Platform
Cancer Screening Cell lines & Animal Models
Whole exome sequencing
iPSCs for Drug Screening
Genomics Analysis for Personalized Medicine/Diagnosis
Molecular Dynamics product v2 (PleMD v2.0)
R+D
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Preliminar Validation
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Clinical validation
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Register
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Ready to Market
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OTHER TECHNOLOGIES
Company
Product
Type
Therapeutic Area
Indication
Bioftalmik Applied Research
BIOSEARCH
BIOSEARCH
Biomar
FUNDACIÓN PROGRESO Y SALUD
(Servicio Andaluz de Salud)
FUNDACIÓN PROGRESO Y SALUD
(Servicio Andaluz de Salud)
FUNDACIÓN PROGRESO Y SALUD
(Servicio Andaluz de Salud)
FUNDACIÓN PROGRESO Y SALUD
(Servicio Andaluz de Salud)
FUNDACIÓN PROGRESO Y SALUD
(Servicio Andaluz de Salud)
Histocell
PROTEOS BIOTECH
Bioftalmik Applied Research
Bioftalmik Applied Research
FUNDACION PROGRESO Y SALUD / IATA
(Servicio Andaluz de Salud)
FUNDACION PROGRESO Y SALUD / IATA
(Servicio Andaluz de Salud)
FUNDACION PROGRESO Y SALUD / IATA
(Servicio Andaluz de Salud)
GH Genhelix
Histocell
Histocell
IGEN BIOTECH
Customized Inyector for intraocular surgeries
CARONOSITOL®
HEREDITUM®
Culture and maintenance of bank cells under GMP conditions
Medical devices
Others
Others
Biomaterials & Tissue Therapy
Ophthalmology and optometry
Metabolic/Endocrinology
Infections
FIBAO-95
Medical devices
FIBAO-103 - 44- 57 -68
CIBER-BBN
CIBER-BBN
CIBER-BBN
CIBER-BBN
CIBER-BBN
PROTEOS Biotech
Clinical
Register
Ready to Market
validation
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R+D
Preliminar Validation
Ocular surgery
Polycystic Ovary Syndrome (PCOS)
Lactational mastitis
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Kidney and Genitourinary system
Mesh for surgical treatment of incontinence
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Medical devices
Others
Aspiration and washing device for endoscopic surgical procedures / Device for laparoscopy /
Thoracic retractor / Thoracic gluteus retractor
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FIBICO-40 - 35
Medical devices
Dermatology
Composition for healing of pressure ulcers / Composition based on polyphenols
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FISEVI-80
Medical devices
Muskuloskeletal Disorders
Device for treatment of bone disease
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FRM-8
Medical devices
Women´s health
Progressive surgical distractor
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HR006-1
Culture and maintenance of bank cells under GMP conditions
Biocompatible contrast medium for ocular surgery
Customizable tissue adhesive film for ocular surgery
Biomaterials & Tissue Therapy
Biomaterials & Tissue Therapy
Medical devices
Biomaterials & Tissue Therapy
Dermatology
Ophthalmology and optometry
Ophthalmology and optometry
Wound healing
Culture and maintenance of bank cells under GMP conditions
Ocular surgery
Ocular surgery
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<<<<<<
Artificial Cornea
Biomaterials & Tissue Therapy
Ophthalmology and optometry
Corneal ulcers
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Europe
Artificial Skin / Artificial Dermis
Biomaterials & Tissue Therapy
Dermatology
Skin regeneration
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Europe
Bone regeneration
Biomaterials & Tissue Therapy
Muskuloskeletal Disorders
Bone and cartilage regeneration
<<<<<< <<<<<<
Europe
GHL - OPT. Cell culture optimization for cell and gene therapies
HR004-1
HR007
Paraffin DNA Kit
BBN-BIOMATER. Production & Characterization of Functionalized Biomaterials
and Scaffolds for Regenerative medicine
Bone morphogenetic protein
Membrane with mesenchymal cells
Peptide
BBN-Biomaterial
Collagenase
Biomaterials & Tissue Therapy
Biomaterials & Tissue Therapy
Biomaterials & Tissue Therapy
Others
Muskuloskeletal Disorders
Dermatology
Others
Maintenance Cell Culture / gen therapy
Bone regeneration
Tissular Regeneration
DNA extraction kit for paraffin samples
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<<<<<<
Biomaterials & Tissue Therapy
Biomaterials & Tissue Therapy
Biomaterials & Tissue Therapy
Biomaterials & Tissue Therapy
Biomaterials & Tissue Therapy
Biomaterials & Tissue Therapy
Muskuloskeletal Disorders
Muskuloskeletal Disorders
Muskuloskeletal Disorders
Dermatology
Biomaterials
<<<<<<
Bone tissue
Cartilage tissue
Bone tissue
Production and nanostructuring of biomaterial and nanoparticles
Debridement of chronic dermal ulcers and severely burned areas
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*Based on data provided by ASEBIO associated companies. APRIL 2013.
www.asebio.com
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Studies Location
Worldwide
Europe
Europe
Europe
Europe
Worldwide
Worldwide
Europe
Europe
Spain
Worldwide
Spain
Europe
Spanish Red Biotech Pipeline
*
Spanish Red Biotech Pipeline 2013
DRUGS: MULTINATIONAL SUBSIDIARIES **
D I A GNOST IC S A ND P E R S O NA L I ZE D M E DIC IN E
Kidney and Genitourinary system 2%
Women´s health 2%
Dermatology 2%
Infections 3%
Autoimmune
& Inflammation 5%
Cancer 30%
Cardiovascular and
circulatory
systems 6%
Ophthalmology and
optometry 8%
Digestive System
8%
Genetic
Diseases and
Dysmorphic
syndromes
13%
Blood and
Lymphatic systems
10%
Central Nervous
System 11%
Company
Product
Type
Therapeutic area
Indication
Genzyme
Genzyme
Genzyme
Genzyme
Merck KGaA
Merck KGaA
Merck KGaA
Merck KGaA
MSD
MSD
MSD
MSD
MSD
AbbVie
AbbVie
AbbVie
AbbVie
AbbVie
AbbVie
Amgen
Amgen
Amgen
Amgen
Amgen
Amgen
Amgen
Amgen
Amgen
Amgen
Amgen
Amgen
Amgen
Amgen
Amgen
Biogen Idec
Biogen Idec
Biogen Idec
Merck KGaA
Merck KGaA
MSD
MSD
MSD
MSD
MSD
MSD
MSD
MSD
MSD
MSD
MSD
MSD
MSD
MSD
MSD
MSD
MSD
MSD
MSD
MSD
MSD
TiGenix
AbbVie
AbbVie
AbbVie
AbbVie
AbbVie
Amgen
Amgen
Amgen
Amgen
Amgen
Amgen
Amgen
Amgen
Amgen
Amgen
Amgen
Amgen
Amgen
Amgen
Amgen
Merck KGaA
MSD
MSD
MSD
MSD
MSD
MSD
TiGenix
TiGenix
Eliglustat
Alemtuzumab
Mipomersen
Ataluren
MEKI
TH-302
Rebif
Erbitux®
V260
Niacin/Laropitant
Vernakalant
Aprepitant
Corifollitropin
HCV Interferon-Free Combination (genotype 1)
HUMIRA (adalimumab)
Daclizumab
Levodopa/Carbidopa Intestinal Gel (LCIG)
Elotuzumab
Elagolix
AMG 386
Blinatumomab
Darbepoetin alfa
Darbepoetin alfa
Rilotumumab
Ganitumab
Motesanib
Denosumab
Selective antagonist of Sigma-1 receptor
Cinacalcet
Cinacalcet
AMG 416
Talimogene laherparepvec
Denosumab
AMG 145
Dexpramipexole
BG-12
IFN ß 1a pgilated
Stimuvax
Luveris
V114
V212
V221
V501
V503
Golimumab
Infliximab
Odanacatib
Anacetrapib
Ezetimibe
MK-3102
Sitagliptin
MK3415A (MK3415 + MK6072)
Raltegravir
Boceprevir
Peg-Interferon / Ribavirin
Posaconazole
MK-4305
Preladenant
Ridaforolimus
Mometasone
Cx601
BT-061
GLPG0634
Veliparib
ABT-719
Atrasentan
AMG 386
AMG 785
AMG 827
AMG 888
Ganitumab
Romiplostim
Omecantiv mecarbil
Denosumab
Panitumumab
Denosumab
AMG 181
AMG 745
AMG 747
AMG 334
AMG 337
DI-17 E6
V710
MK-8808
Robatumumab
Temozolamide
MK-7655
Dalotuzumab
Cx611
Cx621
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Vaccines
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Gene / Cell Therapy
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Vaccines
Vaccines
Vaccines
Vaccines
Vaccines
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Gene/Cell Therapy
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Gene / Cell Therapy
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Vaccines
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Biodrugs
Gene/Cell Therapy
Gene/Cell Therapy
Digestive System
Central Nervous System
Cardiovascular and ciculatory systems
Central Nervous System
Cancer
Cancer
Central Nervous System
Cancer
Infections
Cardiovascular and ciculatory systems
Cardiovascular and ciculatory systems
Cancer
Women´s health / Kidney and Genitourinary system
Infections
Autoimmune & Inflammation
Central Nervous System
Central Nervous System
Cancer
Women’s Health
Cancer
Blood and Lymphatic systems
Cardiovascular and ciculatory systems
Blood and Lymphatic systems
Cancer
Cancer
Cancer
Muskuloskeletal Disorders
Cardiovascular and ciculatory systems
Kidney and Genitourinary system
Kidney and Genitourinary system
Kidney and Genitourinary system
Cancer
Cancer
Cardiovascular and ciculatory systems
Central Nervous System
Central Nervous System
Central Nervous System
Cancer
Women´s Health
Infections
Infections
Infections
Infections
Infections
Autoimmune & Inflammation
Autoimmune & Inflammation
Muskuloskeletal Disorders
Cardiovascular and ciculatory systems
Cardiovascular and ciculatory systems
Metabolic / Endocrinology
Metabolic / Endocrinology
Infections
Infections
Infections
Infections
Infections
Central Nervous System
Central Nervous System
Cancer
Respiratory and Pulmonary system
Autoimmune & Inflammation / Digestive System
Autoimmune & Inflammation
Autoimmune & Inflammation
Cancer
Kidney and Genitourinary system
Kidney and Genitourinary system
Cancer
Muskuloskeletal Disorders
Autoimmune & Inflammation
Cancer
Cancer
Cancer
Cardiovascular and ciculatory systems
Autoimmune & Inflammation
Cancer
Cancer
Autoimmune & Inflammation / Digestive System
Muskuloskeletal Disorders
Central Nervous System
Central Nervous System
Cancer
Cancer
Infections
Autoimmune & Inflammation
Cancer
Cancer
Infections
Cancer
Autoimmune & Inflammation
Autoimmune & Inflammation
Lysosomal Diseases; Gaucher Disease
Multiple Sclerosis
Hypercholesterolemia
Duchenne Muscular Dystrophy
Colorectal Cancer, Pancreas, Melanoma
Pancreas
Clinically Isolated Syndrome
Gastric Cancer
Vaccines Prevenction Rotavirus
Atheroschlerosis
Atheroschlerosis
CINV
Fertility
Hepatitis C
Hidradenitis Suppurativa / Axial Spondyloarthritis / Peripheral Spondyloarthritis / Uveitis / Pediatric Crohn’s Disease
Relapsing Remitting Multiple Sclerosis
Advanced Parkinson’s Disease
Multiple Myeloma
Endometriosis / Uterine Fibroids
Ovarian Cancer
Acute lymphoblastic leukemia
Anemia in heart failure
Myelodysplastic syndromes
Various cancer types
Pancreatic Cancer
Non-small cell lung cancer
Bone-related conditions; Male osteoporosis
Cardiovascular diseases in patients with secondary hyperparathyroidism and chronic kidney desease undergoing manteinance dialysis
Post renal transplant
Pediatric Secondary Hyperparathyrodism
Secondary Hyperparathyrodism
Malignant melanoma
Delay or prevention of bone metastasis in prostate cancer and in breast cancer
Hypercholesterolemia
Amiotrophic lateral Sclerosis
Multiple Sclerosis
Multiple Sclerosis
Head and Neck Cancer, Breast Cancer
Assisted reproductive technology
Vaccines Prevention Pneumoccoccal Disease
Vaccines Inmunocompromised patients
MMRV
Vaccines Prevention of HPV
Vaccines Prevention of HPV
Spondiloarthrosis
Several diseases
Osteoporosis
Diabetes
Atheroschlerosis
Diabetes
Diabetes
Recurrent Clostrodium difficile infection
HIV
Hepatitis C
Hepatitis C
Mycoses
Primary Insomnia
Parkinson’s Disease
Cancer
Asthma
Fistulizing Crohn’s diseases
Rheumatoid Arthritis / Psoriasis
Rheumatoid Arthritis
BRCA-Deficient Breast Cancer / Other Cancers
Acute Kidney Injury
Diabetic Nephropathy
Various cancer types
Bone-related conditions; Osteoporosis
Inflammatory Diseases
Cancer
Cancer
Chemotherapy-induced thrombocytopenia
Heart failure
Rheumatoid arthritis
Locally advanced head and neck cancer
Giant cell tumor of the bone
Crohn´s disease
Muscle-wasting disorders; Muscle loss in different conditions
Schizophrenia
Migraine
Gastric cancer
Colorectal Cancer, Prostate cancer, solid tumors
Vaccines Inmunocompromised patients
Reumathoid Arthritis
Sarcoma
Glioblastoma
Bacterial Infections
Cancer
Rheumatoid arthritis
TBD
DRUG S: MU LTI N A TI O NA L S UB S I D I A RIES
Metabolic / Endocrinology 2%
Blood and Lymphatic systems 2%
Respiratory and Pulmonary system 1%
Women´s health 3%
Digestive System 3%
Cancer 27%
Muskuloskeletal
Disorders 4%
Kidney and
Genitourinary
system 7%
Cardiovascular and ciculatory systems
10%
Infections 15%
Autoimmune
& Inflammation
13%
Central Nervous
system 13%
Phase I
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Ready to Market
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DIAGNOSTICS AND PERSONALIZED MEDICINE
www.asebio.com
Spanish Bioindustry Association
ASEBIO, the Spanish Bioindustry Association, encompasses over 230 firms, associations, foundations, universities, technology and
research centers which carry out activities directly or indirectly related to biotechnology.
The wide number of associates makes ASEBIO the most appropriate meeting platform to face up the challenges of developing the
biotechnology sector in Spain.
Around 600 companies research and develop products in the Spanish biotechnology sector.
Company
Product
Type
Therapeutic Area
Indication
Araclon Biotech
Asociación I+D Progenika
Bioftalmik Applied Research
Bioftalmik Applied Research
Biogen Idec
BIOMOL-INFORMATICS
GENDIAG
IMEGEN
IMEGEN
IMMUNOSTEP
Life Length
Myriad Genetics
Myriad Genetics
Myriad Genetics
Operon
Oryzon
Oryzon
Oryzon
SECUGEN
SECUGEN
SECUGEN
VENTER PHARMA
Asociación I+D Progenika
PANGAEA BIOTECH
Asociación I+D Progenika
Bioftalmik Applied Research
Bioftalmik Applied Research
DIGNA Biotech
FERRER
FUNDACIÓN PROGRESO Y SALUD (Servicio Andaluz de Salud)
GENDIAG
IMMUNOSTEP
IMMUNOSTEP
Operon
OWL
PANGAEA BIOTECH
PANGAEA BIOTECH
SISTEMAS GENÓMICOS
SISTEMAS GENÓMICOS
SISTEMAS GENÓMICOS
SISTEMAS GENÓMICOS
SISTEMAS GENÓMICOS
SISTEMAS GENÓMICOS
SISTEMAS GENÓMICOS
Vivia Biotech
Vivia Biotech
Vivia Biotech
Vivia Biotech
Biomedal
Biomedal
Biomedal
Biomedal
BTI Biotechnology Institute
CIBERER
DIGNA Biotech
FUNDACIÓN PROGRESO Y SALUD (Servicio Andaluz de Salud)
FUNDACIÓN PROGRESO Y SALUD (Servicio Andaluz de Salud)
FUNDACIÓN PROGRESO Y SALUD (Servicio Andaluz de Salud)
FUNDACIÓN PROGRESO Y SALUD (Servicio Andaluz de Salud)
FUNDACIÓN PROGRESO Y SALUD (Servicio Andaluz de Salud)
Inbiomed
Thrombotargets
AlphaSIP
AlphaSIP
CIBER-BBN
CIBER-BBN
CIBER-BBN
CIBER-BBN
CIBER-BBN
CIBER-BBN
CYTOGNOS
CYTOGNOS
DIGNA Biotech
DIGNA Biotech
IGEN BIOTECH
IGEN BIOTECH
IMMUNOSTEP
Integromics
LAIMAT
Operon
Operon
Operon
Operon
Operon
Oryzon
Oryzon
Parque Científico de Madrid
Kit ABtest
PULMOCHIP
Point of Care Diagnosis
Limbokit
Ab anti-JCV assay
BIOMOL-EXOME
DNA-Chip, Trombo inCode
Sequence Capture
NextGenDx
ThromboStep
TAT Test
CCP Pulmon
Melapath Dx
Colaris Full
LisaKIT Chagas
GynEC-Dx
Cx-Bladder
OV-Plex
DNA SEQUENCING
NEXT GEN SEQUENCING
GENOTYPING
LacTEST 2,7 powder for oral solution
PROIMPLANT
EGFR serum mutation test
ENDOMETRIX
Point of Care Diagnosis
Point of Care Diagnosis
Electrochemical biosensor. Mutations detection
EPITYPE
GENYO-1
Point of Care Diagnosis
Hemodilución (Bmplex)
Infiltration in CNS
Norovirus
EM metabolic markers
EGFR enrichment test
BRCA1 RNA test
MamaGeneProfile®
Nuevo CardioGeneProfile®
Inmutest®
ONCOGeneProfile®
OTOGeneProfile®
NeuroGeneProfile®
MRisk®
Personalized Medicine Test in Hematological Malignances
Personalized Medicine Test in Hematological Malignances
Personalized Medicine Test in Hematological Malignances
Personalized Medicine Test in Hematological Malignances
IVYLISA GFD
IVICHECK GFD
IVYLISA DGP8
IVYLISA BLG
PRGF-Endoret Technology
Diagnostic Kit - HHT
Osteosarcoma diagnostic
FIBAO-130 - 122 - 93 - 92 - 141 / FISEVI 124 - 125 - 133
FIBAO-144
FIBAO-85
FIBICO-45
GENYO-13001
Ubiquitin and SUMO traps
Diagnosis sensor
Double Trust
OncoSafe
BBN Biosensors. Diagnosis
BBN-Imaging. Biomedical imaging
BBN-CONTRAGENT. Contrast agents for MRI
BBN-AGN-CONTR. Contrast agents based on nanoparticles with magnetic and paramagnetic properties
BBN-BIOMARK. Biomarkers with direct clinical application
BBN-Device
Diagnosis flow cytometry kit
Diagnosis flow cytometry kit
EM metabolic markers
MTA markers
Vaginitis Diagnostic Kit
Apta4
Mastocitosis (SMCD)
Genomics Analysis for Personalized Medicine/Diagnosis
Diagnosis sensor
HLA B*27
HLA B*5701
Chlamydia Trachomatis
Neisseria Gonorrhoeae
Herpes Virus
Early Diagnosis
Early Diagnosis
Diagnóstico Molecular de Cáncer
Biomarkers
Central Nervous System
Cancer
Ophthalmology and optometry
Ophthalmology and optometry
Infections
Genetic Diseases and Dysmorphic syndromes
Cardiovascular and circulatory systems
Genetic Diseases and Dysmorphic syndromes
Genetic Diseases and Dysmorphic syndromes
Blood and Lymphatic systems
Cancer / Cardiovascular and circulatory systems
Cancer
Cancer/ Dermatology
Cancer
Infections
Cancer
Cancer
Cancer
Genetic Diseases and Dysmorphic syndromes
Genetic Diseases and Dysmorphic syndromes
Ophthalmology and optometry
Digestive System
Women´s health
Cancer
Kidney and Genitourinary system
Ophthalmology and optometry
Ophthalmology and optometry
Alzheimer´s disease diagnostic kit in the early stages
Non invasive diagnosis of lung cancer
Dry eye & Blaepharitis differential inmediate POC diagnosis and monitoring
Limbal deficiency (Corneal Blindness) diagnosis device
Detection of JCV
Genetic diadnostic (Human Exome)
Detection of the 12 most relevant genetic variants associated to thrombosis
Exome Analysis, Genomics
Genetic Analysis, Gene Panels
Autoimmune Thrombocytopenia Diagnosis by flow cytometry
Age related diseases; Age related diseases / Cancer / Cardiovascular / Degenerative diseases, etc.
Lung Cancer prognostic test based on Cell Cycle Progression Genes
Genetic profile to test pathogenic status of Melanoma biopsy
Test for all hereditary Colorrectal sindromes such as Lynch Syndrome or Familial Adenomatous Poliposis
Tripanosoma Cruci infection Diagnosis
Endometrial Cancer (in colaboration with Laboratorios Reig Jofré)
Bladder Cancer
Ovarian
Genetic Diagnosis
Genetic Diagnosis
Genetic risk for Age related Macular Degeneration
Subject with lactose intolerance
Female infertility
Lung cancer, EGFR mutated
Non invaside diagnosis of endometriosis
Pediatric Ocular Allergy differential inmediate POC diagnosis and monitoring
Keratocomus inmediate POC diagnosis and monitoring
Cancer
Cancer
Central Nervous System
Blood and Lymphatic systems
Blood and Lymphatic systems
Infections
Central Nervous System
Cancer
Cancer
Cancer
Cardiovascular and circulatory systems
Autoimmune & Inflammation
Cancer
Ophthalmology and optometry
Central Nervous System
Dermatology
Cancer / Blood and Lymphatic systems
Cancer / Blood and Lymphatic systems
Cancer / Blood and Lymphatic systems
Cancer / Blood and Lymphatic systems
Digestive System
Digestive System
Digestive System
Digestive System
Ophthalmology and optometry
Genetic Diseases and Dysmorphic syndromes
Cancer
Cancer
Central Nervous System
Kidney and Genitourinary system
Cardiovascular and circulatory systems
Autoimmune & Inflammation
Cancer/ Central Nervous System
Central Nervous System
Blood and Lymphatic systems
Cancer
CUP
Metastasis
Fast diagnosis of stroke and its differentiation from stroke-mimicking conditions
Detection of hemodilution in bone marrow samples
Detection of Leptomeningeal disease
Norovirus diagnostic
EM diagnostic
Lung cancer, EGFR mutated
Solid tumors
Breast Ovarian cancer
Cardiovascular Risk
Food intolerance
Oncology
Hearing Impairment
Neurological diseases
Melanoma
Multiple Myeloma
Chronic Lymphocytic Leukemia
Acute Myeloid Leukemia
Acute Lymphocytic Leukemia
Monitoring of the gluten free diet in celiac patients
Monitoring of gluten free diet in celiac patients
Diagnosis of celiac disease / Monitoring of gluten free diet
Monitoring of the intestinal permeability
Ophtalmology
Hereditary Hemorrhagic Telangiectasia (HHT)
Childrend osteosarcoma
Adenocarcinome, Breast, Lung, Colorectal,Cervix tumors and Pancreas cancer / 5-FU treatment Prognosis (Colorectal and Breast Cancer)
Sensorineural hearing loss
Acute Renal Failure
Vacular Calcification
Lupus erythematosus
Cancer, Parkinson´s Disease & Alzheimer´s Disease
Alzheimer Disease
Thrombotic risk Kit
Colorectal Cancer diagnostic kit
Diagnostics
Diagnosis and Imaging
Diagnostics
Nanotechnology / Diagnostic and Imaging
Digestive System
Autoimmune & Inflammation
Cancer
Central Nervous System
Cancer
Women´s health
Digestive System
Blood and Lymphatic systems
Intake monitoring. Obesity. Nutrition
Diagnosis and follow-up of allergies (Type I Hypersensitivity)
Multiple Myeloma, Non-Hodking Lymphoma and Glioma
EM diagnostic
Answer EM treatment
Infectious diseases testing
Diagnosis of gastrointestinal disorders
Diagnosis and Prognosis Test
Diagnostics and Imaging / Screening
Early diagnosis of various diseases
Detection of HLA B*27 allele
Detection of HLA B*5701 allele
Chlamydia Trachomatis detection
Neisseria Gonorrhoeae detection
Herpes Virus detection
Alzheimer Disease
Parkinson Disease
Cancer and Cardiopaty diagnosis
Diagnostic
Diagnostic
Diagnostic
Diagnostic
Diagnostic
Diagnostic
Biomarkers
Diagnostic
Diagnostic
Diagnostic
Diagnostic
Diagnostic
Diagnostic
Diagnostic
Diagnostic
Diagnostic
Biomarkers
Diagnostic
Diagnostic
Diagnostic
Diagnostic
Biomarkers
Biomarkers
Diagnostic
Diagnostic
Biomarkers
Biomarkers
Biomarkers
Biomarkers
Biomarkers
Biomarkers
Biomarkers
Diagnostic
Diagnostic
Diagnostic
Diagnostic
Biomarkers
Diagnostic
Biomarkers
Biomarkers
Diagnostic
Diagnostic
Diagnostic
Autoimmune & Inflammation
Genetic Diseases and Dysmorphic syndromes
Genetic Diseases and Dysmorphic syndromes
Genetic Diseases and Dysmorphic syndromes
Genetic Diseases and Dysmorphic syndromes
Genetic Diseases and Dysmorphic syndromes
Central Nervous System
Central Nervous System
Cancer / Cardiovascular and circulatory systems
Preliminar
Clinical
Ready to
Register
Validation
validation
Market
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R+D
*Based on data provided by ASEBIO associated companies. APRIL 2013. ** Only coloured phases have been developed in Spain
www.asebio.com
Studies Location
Worldwide
Europe and America
Worldwide
Worldwide
Europe and Usa
Europe
Europe
Europe
Worldwide
Worldwide
Worldwide
Europe
Europe
Spain & Portugal
Europe
Worldwide
Worldwide
Worldwide
Worldwide
Worldwide
Worldwide
Europe
Europe
Worldwide
Worldwide
Europe
Worldwide
Worldwide
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe
Europe