Juan Sebastian Dañobeitia Franco

Juan Sebastian Dañobeitia
1111 Highland Avenue
Wisconsin Institutes for Medical Research - Office 5157
Department of Surgery – Division of Organ Transplantation
University of Wisconsin - Madison
Madison, WI 53705
Phone: 608-262-9602
Fax: 608-262-3330
Email: [email protected]
CURRICULUM VITAE
Direccion:
Wisconsin Institutes for Medical Research, 1111
Highland Avenue Room 5168
Pagina web:
http://www.surgery.wisc.edu/research/researcherslabs/fernandez/
Correo electronico:
[email protected]
FORMACION ACADEMICA.
1998- 2004 – Medico Cirujano
Pontificia Universidad Javeriana, Bogotá, Colombia.
2008 – 2012 - Doctorado en Ciencias Biomédicas (Inmunología de Trasplantes)
University of Wisconsin-Madison.
Department of Comparative Biomedical sciences.
INTERNADO, ELECTIVAS y EXPERIENCIA PROFESIONAL
William J. Harrington Training Program for Latin American Students.
Sub-Internship en Cirugia General – Universidad de Miami/Jackson Memorial
Hospital. University of Miami Miller School of Medicine - Miami, FL.
Diciembre 2003 – Abril 2004
Mount Sinai School of Medicine - Mount Sinai Hospital.
Cirugia General y Colo-rectal, Departamento de Cirugia - Division de cirugia de
Colon y Recto. Mount Sinai School of Medicine, New York, NY.
Enero - Julio 2003.
Servicio Social Obligatorio
Hospital Tunjuelito E.S.E. Bogota, Colombia.
Junio 2004 – Junio 2005
INVESTIGACION
Coordinador del Laboratorio de Trasplante de Islotes Pancreaticos de la
Universidad de Wisconsin.
Islet Transplant Core Facility.
University
of
Wisconsin-Madison.
Department
of
Surgery,
Division
of
Transplantation. Octubre 2006 a la fecha.
Investigador Asociado.
Desarrollo del programa de aislamiento de islotes pancreaticos – Hospital San
Ignacio– Pontificia Universidad Javeriana. Bogota – Colombia. Diciembre 2005 a
Septiembre 2006.
LINEA DE INVESTIGACION
Medicina regenerativa – Terapias de reemplazo celular.
Inmunobiologia de la lesion isquemica en organos transplantables.
Estres oxidativo y balance energetico en la preservación de órganos.
Aspectos
transplante.
técnicos
de
aislamiento
de
islotes
pancreáticos
para
PUBLICACIONES
1. Danobeitia JS, Hanson MS, Sperger JS, Park E, Chlebeck P,
Schwarznau A, Fernandez LA. IL-1ra Inhibits Systemic Inflammation and
Increases Isolated Islet Quality and Function in a Brain Death Non-Human
Primate Model. (En preparacion)
2. Danobeitia JS, Sperger JS, Hanson MS, Park E, Chlebeck P, Fernandez
LA. Donor Pre-treatment with IL-1 Receptor Antagonist Attenuates Early
Innate Immune Activation and Inflammation in the Liver of Brain Dead
Non-human Primates. (Sometido para revision)
3. Hirsch, D., Odorico, J., Danobeitia, J. S., Alejandro, R., Rickels, M. R.,
Hanson, M., Radke, N., Baidal, D., Hullett, D., Naji, A., Ricordi, C.,
Kaufman, D., and Fernandez, L. Early Metabolic Markers that Anticipate
Loss of Insulin Independence in Type 1 Diabetic Islet Allograft Recipients.
Am J Transplant 12: 1275-1289, 2012.
4. Danobeitia, JS, Sperger, JM, Hanson, MS., Chlebeck, PJ, Roenneburg,
DA., Connor, JX., Park, EE.,Sears, ML., Schwarznau, A, Fernandez, LA.
Early Activation of the Inflammatory Response in the Liver of Brain-Dead
Non-Human Primates. J Surg Res, Nov. 2011 (Epub ahead of print).
5. Hirsch D, Odorico J, Radke N, Hanson M, Danobeitia JS, Hullett D,
Alejandro R, Ricordi C, Fernandez L. Correction of insulin sensitivity and
glucose disposal after pancreatic islet transplantation: preliminary results.
Diabetes Obes Metab. 2010 Nov;12(11):994-1003.
6. Hanson M, Park E, Sears M, Greenwood K, Danobeitia J, Hullett D, et al.
A simplified approach to human islet quality assessment. Transplantation.
2010 May;89(10):1178-88.
7. Kaddis J*, Danobeitia J*, Niland J, Stiller T, Fernandez L. Multicenter
analysis of novel and established variables associated with successful
human islet isolation outcomes. Am J Transplant. 2010 Mar;10(3):646-56.
* Both authors contributed equally to this work.
8. Schwarznau A, Hanson M, Sperger J, Schram B, Danobeitia J,
Greenwood K, et al. IL-1beta receptor blockade protects islets against proinflammatory cytokine induced necrosis and apoptosis. J Cell Physiol.
2009 Aug;220(2):341-7.
9. Bernal J, Martinez F, Henao F, Pulido H, Mejia G, Benavides C, Echeverri
GJ, Uribe AM, Danobeitia JS. Use of nylon filters for the purification of
canine pancreatic islets: Standardization of the technique. Universitas
Médica. 2009 Oct; 50 (4): 452-467
10. Hanson M, Steffen A, Danobeitia J, Ludwig B, Fernandez L. Flow
cytometric quantification of glucose-stimulated beta-cell metabolic flux can
reveal
impaired
islet
functional
potency.
Cell
Transplant.
2008;17(12):1337-47.
PRESENTACIONES EN CONGRESOS NACIONALES E INTERNACIONALES
Toll-Like Receptor and Complement Crosstalk Regulate the Inflammatory
Response after Kidney Ischemia-Reperfusion Injury
Presentado en el Congreso Americano de Trasplantes (American Transplant
Congress), Boston, MA, Junio 2012
Donor Pre-treatment with IL-1 Receptor Antagonist Attenuates Early Innate
Immune Activation and Inflammation in the Liver of Brain Dead Non-human
Primates.
Presentado en el sexton Congreso Anual de la Sociedad de Cirujanos
Academicos y la Asociacion para el Avance de la Cirugia Academica
(Sixth Annual Academic Surgical Congress, Society of University
Surgeons and Association for Academic Surgery). Huntington Beach,
California, February 2011.
IL-1 receptor blockade as a therapeutic strategy for the treatment of braindead organ donors.
Presentado en la cumbre anual de investigacion de la Universidad de
Wisconsin-Madison (Annual Research Summit at the Epicenter in
Verona). Madison, WI, Enero, 2011.
Update in Islet Transplantation Immunobiology.
Conferencista invitado – I Simposio Internacional de Trasplante Células
Madre y Médula Ósea. Fundación Cardiovascular de Colombia FCV,
Colombia. Octubre, 2010.
Organ donor management strategies and the role of innate immunity.
Presentado en la Universidad de Wisconsin – Escuela de Medicina Departmento de Cirugia – Actualizacion en Investigacion en transplantes.
March 2010.
A Non-Human Primate Model for the Characterization of Systemic
Inflammatory Changes Related to Brain Death.
Presentado en el Congreso Americano de Trasplantes (American
Transplant Congress),, Boston, MA, Julio 2009.
Comparison of two collagenase blends for the isolation of human
pancreatic islets.
Presenado en el Congreso Internacional de la Sociedad para Trasplante
Celular y la Sociedad de Trasplante de Pancreas e Islotes Pancreaticos.
Minneapolis MN, Septiembre, 2007.
Extended
quality control assessment of human islet isolation outcomes
using Serva NB1 collagenase and neutral protease. The UW-Madison
experience.
Presenado en el Congreso Internacional de la Sociedad para Trasplante
Celular y la Sociedad de Trasplante de Pancreas e Islotes Pancreaticos.
Minneapolis MN, Septiembre, 2007.
ABSTRACTS
1. Froyshteter AB, Danobeitia JS, Sperger JM, Connor JX, Hanson MS, and
Fernandez LA Activation of systemic inflammatory events following brain
death in a non-human primate model. The Journal of surgical research
158(2):204-5, 2010 Feb
2. Schwarznau A, Hanson MS, Sperger JM, Schram BR, Danobeitia JS,
Fernandez LA. IL- 1ra Prevents Pro-Inflammatory Cytokine Mediated
Dysfunction in Cultured Rat Islets. American Transplant Congress.
Boston, MA, 2009
3. Hanson MS, Sperger JM, Connor JX, Armann B, Danobeitia JS, Moss MJ,
Greenwood KK, Fernandez LA. Pancreata from Donation after Cardiac
Death Donors Show Increased Oxidative Stress Which Presents
Challenges
for
the
Successful
Isolation
of
Islets
for
Clinical
Transplantation. American Transplant Congress. Boston, MA, 2009
4. Sperger JM, Hanson MS, Danobeitia JS, Schwarznau A, Contreras JL,
Fernandez LA. Brain Death Induces Changes in Gene Expression in
Heart, Liver and Kidney in Non-
Human Primates. American Transplant
Congress. Boston, MA, 2009
5. Hanson MS, Danobeitia JS, Sears M, Fernandez LA. Brain Death-Induced
Leukocyte Activation Provides Clues as to the Mechanisms of Isolated
Islet Death. American Transplant Congress. Boston, MA, 2009
6. Rajesh D, Roenneburg D, Jankowska-Gan E, Danobeitia JS, Hanson MS,
Torrealba J, Fernandez LA, Odorico JS and Burlingham W. Development
and Characterization Of
NOD/SCID Humanized Mouse Model To Study
Islet Transplant Rejection. ATC meeting. May 2008. Toronto, Canada.
ASOCIACIONES PROFESIONAL
Miembro del la Sociedad Internacional de Trasplante de Pancreas e Isoltes
Pancreáticos (International Páncreas and Islet Transplant Society), 2010 –
Presente.
EDITORIAL ACTIVITIES
Miembro del Comite Editorial Journal of Transplantation Technologies (2010 – a
la fecha).
Jurado - American Journal of Transplantation (2009 a la fecha).
Jurado - Journal of Transplantation (2009 a la fecha).