RosellCV - Neurovascular Research Laboratory, Barcelona
Transcripción
RosellCV - Neurovascular Research Laboratory, Barcelona
Curriculum Vitae, Anna Rosell Novel November 2015 PERSONAL DATA ANNA ROSELL NOVEL, Barcelona, 27-10-1977 Contact: [email protected] /[email protected] Current Address: Neurovascular Research Laboratory Vall d’Hebron Research institute Passeig Vall d’Hebron 119-129, 08035, Barcelona, Spain. Tlf. +34 93 4894029 www.vhir.org / www.lin-bcn.com/neurorepair SUMMARY Researcher at Vall d’Hebron Research Institute Biologist, PhD in Medicine, Universitat Autònoma de Barcelona. Miguel Servet Position, ISCIII-VHIR Publications: 82 Publications as Senior and/or Corresponding Author: 12 Research Projects: 11 (3 as PI) Directed Doctoral Thesis: 5 Patents: 3 (1 licensed) Curriculum Vitae, Anna Rosell Novel SUMMARY OF THE SCIENTIFIC CARRERR Scientific Autobiography: my scientific education and expertise has been focused in the translational study of stroke disease and therapies. As a PhD student at Vall d’Hebron Research Institute (VHIR), I was trained in the biomarkers field and clinical stroke studies, which gave me a solid understanding of the disease from a clinical perspective. After my PhD I moved to the United States at the Massachusetts General Hospital in a world-leading laboratory recognized for their experimental studies in cerebral ischemia and traumatic brain injury, which offered me the opportunity to extend my experience at a more basic and experimental level (with Prof. Eng H LO). A second step forward in my career was the establishment of a new neurorepair research programme as principal investigator at the Neurovascular Research Laboratory at VHIR where I did my PhD it is nowadays a large laboratory that dedicates all its efforts to stroke disease (www.lin-bcn.com). Since 2010 I hold a Miguel Servet position from the Spanish National Institute of Health and Research Agency (Instituto Carlos III) which supports researchers in biomedical institutions with a tenure-track appointment. The focus of my research is the search of new therapies for stroke patients based on neurorepair strategies with specific emphasis on the role of angio-vasculogenesis. This has allowed me to obtain independent funding as PI from national agencies (3 grants), supervise and guide PhD Students (5 presented Thesis,and 1 ongoing) and establish collaborations with other PIs in the neuroscience, regenerative medicine and nanotechnology fields. Scientific Publications & Metrics: H-Index without self-citations: 25 m-Index= 2, 27 Number of Citations: 2,198 Total Publications: 82 (71 Original Contributions, 10 reviews and 1 Comment Letter) Publications as First author: 11 Publications as Last/ Corresponding author: 12 Fellowships and awards: most of my positions have been awarded with a fellowship or position after competitive open applications. This applies to the Predoctoral Fellowship (2003-2005) from the Vall d’Hebron Research Institute, a Postdoctoral Fellowship (2006-2007) from the Spanish Ministry of Science and Education for abroad positions (at Massachusetts General Hospital, USA), a second Curriculum Vitae, Anna Rosell Novel Postdoctoral Fellowship from the Catalan Government Catalan Government Agency for Research (2008-2010) and my current Miguel Servet tenure track position from the Spanish Ministry of Health (Instituto Carlos III since 2010). I also received a fellowship for short-term scientific visits (2013) from the Catalan Government Agency for Research (AGAUR). My doctoral thesis received the Extraordinary Thesis Award from the Universitat Autònoma de Barcelona. Finally one of my publications as Senior author has been awarded with the First ward Ramón Ríos from Foltra Foundation, Spain (2014, awarded to Elisa Carenza the first author of the publication). EDUCATION AND SCIENCE TRAINNING - Doctorate in Medicine, PhD (01/2003-07/2005). Department of Internal Medicine, Neurovascular Research Laboratory, Hospital Vall d’Hebron. Universitat Autònoma de Barcelona, Spain. Doctoral Thesis: “Matrix Metalloproteinases in brain parenchyma: role in tissue damage after human cerebral ischemia”. Universitat Autònoma de Barcelona. July 2005, Excellent Cum Laude. Extraordinary Award from the Universitat Autònoma de Barcelona. - Master (Medicine) and DEA (09/2003-09/2004): “Angiogenesis in Human Cerebral Ischemia: the angiogenic balance (Endostatin/VEGF) during the hyperacute phase after ischemic stroke is related to neurological outcome at short and long term”. Universtat Autònoma de Barcelona. September 2004. - Bachelor degree in Biology (09/1996-02/2001): Special Branch: Animal Biology, Organisms and Systems. Universitat Autònoma de Barcelona, Spain. RESEARCH POSITIONS - Miguel Servet Program for senior researchers (Sistema Nacional de Salud, Fondo de Investigación Sanitaria, Spain). Institut de Recerca Hospital Vall d’Hebron (February 2010Present). - Postdoctoral Researcher (June 2008-February 2010). Neurovascular Research Laboratory Curriculum Vitae, Anna Rosell Novel from Hospital Vall d’Hebron, Neurovascular Unit, Neurology Department. - Research Fellow (September 2007-May 2008). Neuroprotection Research Laboratory, Massachusetts General Hospital; Radiology Department. Harvard Medical School, Program in Neuroscience. - Postdoctoral Fellow (From May 2006-September 2007) at the Neuroprotection Research Laboratory, Massachusetts General Hospital; Radiology Department. Harvard Medical School, Program in Neuroscience. - Postdoctoral fellow (from July 2005-May 2006) from the Neurovascular Research Laboratory from Hospital Vall d’Hebron, Neurovascular Unit, Neurology Department. - Predoctoral fellow (January 2003-July 2005) at the Neurovascular Research Laboratory from Hospital Vall d’Hebron, Neurovascular Unit, Neurology Department. VISITING SCIENTIST - Neuroprotection Research Laboratory, Massachusetts General Hospital; Radiology Department. Harvard Medical School, Programm in Neuroscience. July and August 2013. ACADEMIC AWARDS - Predoctoral Fellowship from the Hospital Vall d’Hebron Research Foundation (2003). - Postdoctoral Fellowship from Ministerio de Educación y Cultura, Spain (2006). - Postdoctoral Fellowship from AGAUR agency, Catalonia, Spain (2008). - Short term- fellowship for postdoctoral scientists (2013) from AGAUR agency, Catalonia, Spain. - Extraordinary Thesis Award from the Universitat Autònoma de Barcelona. - Travel Bursary Award at the XXVIth BRAIN Meeting. Shanghai, China, May 2013. - The paper entitled "In vitro angiogenic performance and in vivo brain targeting of magnetizad endothelial progenitor cells for neurorepair therapies", published in Nanomedicine: Nanotechnology, Biology and Medicine received the First Award Ramón Ríos from Foltra Foundation, Spain (2014). Curriculum Vitae, Anna Rosell Novel PARTICIPATION IN RESEARCH SUPPORT GRANTS - PI13/01094: Estudio de la angiogénesis en pacientes en rehabilitación después del ictus: búsqueda de marcadores de recuperación funcional e identificación de nuevas dianas terapéuticas. Instituto de Salud Carlos III-FIS (2014-2016). PI: Anna Rosell Novel - MULTI-PART (603043)- Multicentre Preclinical Animal Research Team (FP7). Participant Center, Vall d’hebron Research Institute (2013-2015). Neurovascular Research Laboratory, VHIR, Spain. Participating as senior researcher. - ENFERMEDADES VASCULARES CEREBRALES (ICTUS), Redes Temáticas RETICS. INVICTUS, RD12/0014/0005 (01/01/2013-28/02/2016). Neurovascular Research Laboratory, VHIR, Spain. Participating as senior researcher. - ERANETCOORDINATION ACTION, PRPPRI-PIMN EU-2011-1352: Influence of proteases before, during and after stroke: PROTEA Project (2012-2014). Neurovascular Research Laboratory, VHIR, Spain. Participating as senior researcher. - FIS PI10/00694: “Use of Nanoparticles to Potentiate Neurorepair after Ischemic Stroke by Local Guidance of EPCs”. Sistema Nacional de Salud, Fondo de Investigación Sanitaria. Neurovascular Research Laboratory, VHIR, Spain. P.I: Anna Rosell - FIS CP09/00265: “Neurorepair Treatments for Cerebral Ischemia using Endothelial Progenitor Cells (EPCs)”. Sistema Nacional de Salud, Fondo de Investigación Sanitaria, Spain. Neurovascular Research Laboratory, VHIR, Spain. P.I: Anna Rosell - Seventh Framework Programme (FP7): 2007-2.4.2-3. European Stroke Research Network (EUSTROKE). Participant Center: Hospital Universitari Vall d’Hebron, (2008-2012). Neurovascular Research Laboratory, VHIR, Spain. Participating as post-doctoral researcher. - TNR (Neuroreparative therapies for stroke): Centre d’Innovació i Desenvolupament Empresarial (CIDEM) and Ferrer International (2007-2009). Neurovascular Research Laboratory, VHIR, Spain. Participating as post-doctoral researcher. - NIH GRANT: P01 NS055104-NS/NINDS: Matrix and Trophic coupling in the neurovascular Unit. Neuroprotection Research Laboratory, MGH, USA. Participating as post-doctoral researcher. Curriculum Vitae, Anna Rosell Novel FIS 06/0471: “Influence of Endothelial Progenitor Cells (EPCs) on spatial and temporal - modulation of Angiogenesis and Vasculogenesis following human ischemic stroke”. Neurovascular Research Laboratory, VHIR, Spain. Participating as post-doctoral researcher. FIS 05/322: “Brain Ischemia Biomarkers Discovery through Gene Expression and - Proteomics of Distinct Cell Populations obtained with Laser-Capture-Microdissection from Core and Penumbra following Human Stroke”. Neurovascular Research Laboratory, VHIR, Spain. Participating as post-doctoral researcher. FIS 02/0773 “Influence of Matrix Metalloproteinases in Hemorrhagic Transformations after - thrombolytic treatment in ischemic stroke”. Neurovascular Research Laboratory, VHIR, Spain. Participating as pre-doctoral researcher. PUBLICATIONS 1) A. Gamir-Morralla, C. López-Menéndez, S. Ayuso, G.S. Tejeda, J. Montaner, A. Rosell, T. Iglesias, M. Díaz-Guerra. Development of a neuroprotective peptide that preserves survival pathways by preventing Kidins220/ARMS calpain-processing induced by excitotoxicity. Cell Death & Disease. 2015 (in press). 2) Anna Morancho, Feifei Ma, Verónica Barceló, Dolors Giralt, Joan Montaner, Anna Rosell. Impaired vascular remodeling after endothelial progenitor cell transplantation in MMP9 deficient mice suffering cortical cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism. 2015 35(10):1547-51. 3) Ma F, Morancho A, Montaner J, Rosell A. Endothelial progenitor cells and revascularization following stroke. Brain Research. 2015; 1623:150-159. 4) Carenza E, Jordan O, Martínez-San Segundo P, Jiřík R, Starčuk jr. Z, Borchard G, Rosell A*, Roig A*. Encapsulation of VEGF165 in magnetic PLGA nanocapsules for potential local delivery and bioactivity into human brain endothelial cells. Journal of Materials Chemistry B. 2015;3, 2538-2544.* Equal contribution 5) Merino-Zamorano C, Hernández-Guillamon M, Jullienne A, Béhot AL, Bardou I, Parés M, Fernández-Cadenas I, Giralt D, Carrera C, Ribó M, Vivien D, Ali C, Rosell A, Montaner J. NURR1 Curriculum Vitae, Anna Rosell Novel Involvement in Recombinant Tissue-Type Plasminogen Activator Treatment Complications After Ischemic Stroke. Stroke. 2015;46(2):477-84 6) Moniche F, Montaner J, Gonzalez-Marcos JR, Carmona M, Piñero P, Espigado I, Cayuela A, Escudero I, de la Torre-Laviana FJ, Boada C, Rosell A, Mayol A, Jimenez MD, Gil-Peralta A, Gonzalez A. Intra-arterial bone marrow mononuclear cell (BM-MNC) transplantation correlates with GM-CSF, PDGF-BB and MMP-2 serum levels in stroke patients: Results from a clinical trial. Cell Transplant. 2014;23 Suppl 1:S57-64. 7) Campos-Martorell M; Ma Ángeles Montero, Hernández-Guillamón M, Rosell A, Gomis J, Salat D, García-Bonilla L, Montaner J. Rat middle cerebral artery occlusion is not a suitable model for the study of stroke-induced spontaneous infections. PLoS One. 2014 Jun 12;9(6):e99169. 8) Campos-Martorell M, Salvador N, Monge M, Canals F, García-Bonilla L, Hernández- Guillamon M, Ayuso MI, Chacón P, Rosell A, Alcazar A, Montaner J. Brain proteomics identifies possible simvastatin targets in acute phase of stroke in a rat embolic model. J Neurochem. 2014 Jul;130(2):301-12. 9) Elisa Carenza, Verónica Barceló, Anna Morancho, Joan Montaner, Anna Rosell*, Anna Roig*. Rapid synthesis of water-dispersible superparamagnetic iron oxide nanoparticles by a microwave-assisted route for safe labeling of endothelial progenitor cells. Acta Biomaterialia. 2014;10(8):3775-85. * Equal contribution 10) Llombart V, Dominguez C, Bustamante A, Rodriguez-Sureda V, Martín-Gallán P, Vilches A, García-Berrocoso T, Penalba A, Hernández-Guillamon M, Rubiera M, Ribó M, Eschenfelder C, Giralt D, Molina CA, Alvarez-Sabín J, Rosell A, Montaner J. Fluorescent Molecular Peroxidation Products: A Prognostic Biomarker of Early Neurologic Deterioration After Thrombolysis. Stroke. 2014 Feb;45(2):432-7. 11) Campos M, García-Bonilla L, Hernández-Guillamon M, Barceló V, Morancho A, Quintana M, Rubiera M, Rosell A, Montaner J. Combining statins with tissue plasminogen activator treatment after experimental and human stroke: a safety study on hemorrhagic transformation. CNS Neurosci Ther. 2013, 19(11):863-70. 12) García-Berrocoso T, Penalba A, Boada C, Giralt D, Cuadrado E, Colomé N, Dayon L, Canals Curriculum Vitae, Anna Rosell Novel F, Sanchez JC, Rosell A, Montaner J. From brain to blood: New biomarkers for ischemic stroke prognosis. J Proteomics. 2013, 94C:138-148. 13) Hernández-Guillamon M, Ortega L, Merino-Zamorano C, Campos-Martorell M, Rosell A, Montaner J. Mild hypothermia protects against oxygen glucose deprivation (OGD)-induced cell death in brain slices from adult mice. J Neural Transm. 2014 Feb;121(2):113-7. 14) Anna Rosell*, Anna Morancho, Miriam Navarro-Sobrino, Elena Martínez-Saez, Mar Hernández-Guillamon, Silvia Lope-Piedrafita, Verónica Barceló, Francesc Borrás, Anna Penalba, Lidia García-Bonilla, Joan Montaner. Treatment with Endothelial Progenitor Cells or their Secreted Factors Enhances Angiogenic and Neurogenic Responses after focal Cerebral Ischemia in Mice. PLoS One. 2013;8(9):e73244.* Corresponding author. 15) Anna Morancho, Mar Hernández-Guillamon, Cristina Boada, Verónica Barceló, Dolors Giralt, Laura Ortega, Joan Montaner, Anna Rosell. Cerebral Ischemia and Matrix Metalloproteinase-9 Modulate the Angiogenic Function of Endothelial Progenitor Cells. Journal of Cellular and Molecular Medicine. 2013;14(12):1543-53. 16) Carenza E, Barceló V, Morancho A, Levander L, Boada C, Laromaine A, Roig A, Montaner J, Rosell A. In vitro angiogenic performance and in vivo brain targeting of magnetized endothelial progenitor cells for neurorepair therapies. Nanomedicine. 2014 Jan;10(1):225-34. 17) Anna Rosell. Pannexins after stroke: knocking-out membrane channels to improve neurological function. Channels (Austin). 2013;7(2):58-9. Comment on: Bargiotas et al. Channels (Austin). 2012, 6(6):453-6. 18) Navarro-Sobrino M, Hernández-Guillamon M, Fernandez-Cadenas I, Ribó M, Romero IA, Couraud PO, Weksler BB, Montaner J, Rosell A. The angiogenic gene profile of circulating endothelial progenitor cells from ischemic stroke patients. Vasc Cell. 2013;5(1):3. 19) * Anna Rosell, Véronique Agin, Mahbubur Rahman, Anna Morancho, Carine Ali, Jari Koistinaho, Xiaoying Wang, Denis Vivien, Markus Schwaninger, Joan Montaner. Distal occlusion of the middle cerebral artery in mice: Are we ready to assess long-term functional outcome? Translational Stroke Research. 2013; 4 (3):297-307.* corresponding author. 20) Andreu Massot, Miriam Navarro-Sobrino, Anna Penalba, Juan F. Arenillas, Dolors Giralt,; Curriculum Vitae, Anna Rosell Novel Marc Ribó, Carlos A. Molina, José Alvarez-Sabín, Joan Montaner, Anna Rosell. Decreased levels of angiogenic factors in intracranial atherosclerotic disease despite severity-related increase in endothelial progenitor cell counts. Cerebrovascular Diseases. 2013;35(1):81-8. 21) Montaner J, García-Berrocoso T, Mendioroz M, Palacios M, Perea-Gainza M, Delgado P, Rosell A, Slevin M, Ribó M, Molina CA, Alvarez-Sabín J. Brain natriuretic Peptide is associated with worsening and mortality in acute stroke patients but adds no prognostic value to clinical predictors of outcome. Cerebrovasc Dis. 2012;34(3):240-5. 22) Moniche F, Gonzalez A, Gonzalez-Marcos JR, Carmona M, Piñero P, Espigado I, Garcia- Solis D, Cayuela A, Montaner J, Boada C, Rosell A, Jimenez MD, Mayol A, Gil-Peralta A. IntraArterial Bone Marrow Mononuclear Cells in Ischemic Stroke: A Pilot Clinical Trial. Stroke. 2012 Aug;43(8):2242-4. 23) García-Bonilla L, Campos M, Giralt D, Salat D, Chacón P, Hernández-Guillamon M, Rosell A, Montaner J. Evidence for the efficacy of statins in animal stroke models: a meta-analysis. J Neurochem. 2012;122(2):233-43. 24) Bustamante A, Giralt D, Garcia-Bonilla L, Campos M, Rosell A, Montaner J. Citicoline in pre- clinical animal models of stroke: A meta-analysis shows the optimal neuroprotective profile and the missing steps for jumping into a stroke clinical trial. J Neurochem;123(2):217-25. 25) Fernández-Cadenas I, Del Río-Espínola A, Carrera C, Domingues-Montanari S, Mendióroz M, Delgado P, Rosell A, Ribó M, Giralt D, Quintana M, Castellanos M, Obach V, Martínez S, Mar Freijo M, Jiménez-Conde J, Roquer J, Martí-Fábregas J, Molina CA, Alvarez-Sabín J, Montaner J. Role of the MMP9 Gene in Hemorrhagic Transformations After Tissue-Type Plasminogen Activator Treatment in Stroke Patients. Stroke. 2012 May;43(5):1398-400. 26) Montaner J, Mendioroz M, Delgado P, García-Berrocoso T, Giralt D, Merino C, Ribó M, Rosell A, Penalba A, Fernández-Cadenas I, Romero F, Molina C, Alvarez-Sabín J, HernándezGuillamon M. Differentiating ischemic from hemorrhagic stroke using plasma biomarkers: The S100B/RAGE pathway. J Proteomics. 2012 Aug 3;75(15):4758-65. 27) Anna Morancho, Lidia García-Bonilla, Verónica Barceló, Dolors Giralt, Mireia Campos- Martorell, Sandra Garcia, Joan Montaner, Anna Rosell. A new method for focal transient cerebral Curriculum Vitae, Anna Rosell Novel ischemia by distal compression of the middle cerebral artery. Neuropathol Appl Neurobiol. 2012;38(6):617-27. 28) Delgado P, Chacón P, Penalba A, Pelegri D, García-Berrocoso T, Giralt D, Santamarina E, Ribó M, Maisterra O, Alvarez-Sabín J, Rosell A, Montaner J. Lipoprotein-Associated Phospholipase A(2) Activity Is Associated with Large-Artery Atherosclerotic Etiology and Recurrent Stroke in TIA Patients. Cerebrovasc Dis. 2011;33(2):150-158. 29) Nafría C, Fernández-Cadenas I, Mendioroz M, Domingues-Montanari S, Hernández- Guillamón M, Fernández-Morales J, Del Río-Espínola A, Giralt D, Deu L, Delgado P, Rosell A, Montaner J. Update on the Serum Biomarkers and Genetic Factors Associated with Safety and Efficacy of rt-PA Treatment in Acute Stroke Patients. Stroke Res Treat. 2011;2011:182783. 30) García-Berrocoso T, Fernández-Cadenas I, Delgado P, Rosell A, Montaner J. Blood biomarkers in cardioembolic stroke. Curr Cardiol Rev. 2010 Aug;6(3):194-201. 31) Giralt D, Domingues-Montanari S, Mendioroz M, Ortega L, Maisterra O, Perea-Gainza M, Delgado P, Rosell A, Montaner J. The gender gap in stroke: a meta-analysis. Acta Neurol Scand. 2012 Feb;125(2):83-90. 32) Massot A, Pelegri D, Penalba A, Arenillas J, Boada C, Giralt D, Ribó M, Molina CA, Rosell A, Alvarez-Sabín J, Chacón P, Rovira A, Delgado P, Montaner J. Lipoprotein-associated phospholipase A(2) testing usefulness among patients with symptomatic intracranial atherosclerotic disease. Atherosclerosis. 2011;218(1):181-7. 33) Rosell A, Vilalta A, García-Berrocoso T, Fernández-Cadenas I, Domingues-Montanari S, Cuadrado E, Delgado P, Ribó M, Martínez-Sáez E, Ortega-Aznar A, Montaner J. Brain perihematoma genomic profile following spontaneous human intracerebral hemorrhage. PLoS One. 2011;6(2):e16750. 34) Navarro-Sobrino M, Rosell A, Hernández-Guillamon M, Penalba A, Boada C, Domingues- Montanari S, Ribó M, Alvarez-Sabín J, Montaner J. A large screening of angiogenesis biomarkers and their association with neurological outcome after ischemic stroke. Atherosclerosis. 2011;216(1):205-11. 35) Montaner J, Mendioroz M, Ribó M, Delgado P, Quintana M, Penalba A, Chacón P, Molina C, Curriculum Vitae, Anna Rosell Novel Fernández-Cadenas I, Rosell A, Alvarez-Sabín J. A panel of biomarkers including caspase-3 and d-dimer may differentiate acute stroke from stroke-mimicking conditions in the emergency department. J Intern Med. 2011;270(2):166-74. 36) García-Bonilla L, Rosell A, Torregrosa G, Salom JB, Alborch E, Gutiérrez M, Díez-Tejedor E, Martínez-Murillo R, Agulla J, Ramos-Cabrer P, Castillo J, Gasull T, Montaner J. Recommendations guide for experimental animal models in stroke research. Neurologia. 2011;26(2):105-110. 37) García-Bonilla L, Sosti V, Campos M, Penalba A, Boada C, Sumalla M, Hernández- Guillamon M, Rosell A, Montaner J. Effects of acute post-treatment with dipyridamole in a rat model of focal cerebral ischemia. Brain Res. 2011;1373:211-20. 38) Fernandez-Cadenas I, Mendioroz M, Domingues-Montanari S, Del Rio-Espinola A, Delgado P, Ruiz A, Hernandez-Guillamon M, Giralt D, Chacon P, Navarro-Sobrino M, Ribo M, Molina CA, Alvarez-Sabin J, Rosell A, Montaner J. Leukoaraiosis is associated with genes regulating bloodbrain barrier homeostasis in ischaemic stroke patients. Eur J Neurol. 2011;18(6):826-35. 39) Mendioroz M, Fernández-Cadenas I, Rosell A, Delgado P, Domingues-Montanari S, Ribó M, Penalba A, Quintana M, Alvarez-Sabín J, Montaner J. Osteopontin predicts long-term functional outcome among ischemic stroke patients. J Neurol. 2011;258(3):486-93. 40) Morancho A, Rosell A, García-Bonilla L, Montaner J. Metalloproteinase and stroke infarct size: role for anti-inflammatory treatment? Ann N Y Acad Sci. 2010;1207:123-33. 41) Cuadrado E, Rosell A, Colomé N, Hernández-Guillamon M, García-Berrocoso T, Ribo M, Alcazar A, Ortega-Aznar A, Salinas M, Canals F, Montaner J. The proteome of human brain after ischemic stroke. J Neuropathol Exp Neurol. 2010;69(11):1105-15. 42) Hernandez-Guillamon M, Garcia-Bonilla L, Solé M, Sosti V, Parés M, Campos M, Ortega- Aznar A, Domínguez C, Rubiera M, Ribó M, Quintana M, Molina CA, Alvarez-Sabín J, Rosell A, Unzeta M, Montaner J. Plasma VAP-1/SSAO activity predicts intracranial hemorrhages and adverse neurological outcome after tissue plasminogen activator treatment in stroke. Stroke. 2010;41(7):1528-35. 43) Miriam Navarro-Sobrino, Anna Rosell, Mar Hernandez-Guillamon, Anna Penalba; Marc Curriculum Vitae, Anna Rosell Novel Ribó, José Alvarez-Sabín, Joan Montaner. Mobilization, Endothelial Differentiation and Functional Capacity of Endothelial Progenitor Cells after Ischemic Stroke. Microvasc Res. 2010;80(3):317-23. 44) Fernandez-Cadenas I, Del Rio-Espinola A, Rubiera M, Mendioroz M, Domingues-Montanari S, Cuadrado E, Hernandez-Guillamon M, Rosell A, Ribo M, Alvarez-Sabin J, Molina CA, Montaner J. 1.PAI-1 4G/5G polymorphism is associated with brain vessel reocclusion after successful fibrinolytic therapy in ischemic stroke patients. Int J Neurosci. 2010;120(4):245-51. 45) Fernandez-Cadenas I, Mendioroz M, Munuera J, Alvarez-Sabin J, Rovira A, Quiroga A, Corbeto N, Rubiera M, Delgado P, Rosell A, Ribó M, Molina CA, Montaner J. Lower concentrations of thrombin-antithrombin complex (TAT) correlate to higher recanalisation rates among ischaemic stroke patients treated with t-PA. Thromb Haemost. 2009;102(4):759-64. IF: 6.10 46) Domínguez C, Delgado P, Vilches A, Martín-Gallán P, Ribó M, Santamarina E, Molina C, Corbeto N, Rodríguez-Sureda V, Rosell A, Alvarez-Sabín J, Montaner J. Oxidative Stress After Thrombolysis-Induced Reperfusion in Human Stroke. Stroke. 2010;41(4):653-60. 47) Yang Y, Candelario-Jalil E, Thompson JF, Cuadrado E, Estrada EY, Rosell A, Montaner J, Rosenberg GA. Increased intranuclear matrix metalloproteinase activity in neurons interferes with oxidative DNA repair in focal cerebral ischemia. J Neurochem. 2009;112(1):134-49. 48) Miriam Navarro-Sobrino, Anna Rosell, Anna Penalba, Marc Ribó, José Alvarez-Sabín, Israel Fernández-Cadenas, Joan Montaner. Role of endogenous Granulocyte-Macrophage Colony Stimulating Factor following stroke and relationship to neurological outcome. Current Neurovascular Research. 2009;6(4):246-51. 49) Mendioroz M, Fernández-Cadenas I, Alvarez-Sabín J, Rosell A, Quiroga D, Cuadrado E, Delgado P, Rubiera M, Ribó M, Molina C, Montaner J. Endogenous Activated Protein C Predicts Hemorrhagic Transformation and Mortality after Tissue Plasminogen Activator Treatment in Stroke Patients. Cerebrovasc Dis. 2009;28(2):143-150. 50) Tejima E, Guo S, Murata Y, Arai K, Lok J, van Leyen K, Rosell A, Wang X, Lo EH. Neuroprotective effects of over-expressing tissue inhibitor of metalloproteinase TIMP-1. J Neurotrauma. 2009;26(11):1935-41. 51) Park KP, Rosell A, Foerch C, Xing C, Kim WJ, Lee S, Opdenakker G, Furie KL, Lo EH. Curriculum Vitae, Anna Rosell Novel Plasma and Brain Matrix Metalloproteinase-9 After Acute Focal Cerebral Ischemia In Rats. Stroke. 2009;40(8):2836-42. 52) Cuadrado E, Rosell A, Penalba A, Slevin M, Alvarez-Sabin J, Ortega-Aznar A, Montaner J. Vascular MMP-9/TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke: a combined Laser Microdissection and Protein Array Study. J Proteome Res. 2009;8(6):3191-7. 53) Hernández-Guillamon M, Delgado P, Ortega L, Pares M, Rosell A, García-Bonilla L, Fernández-Cadenas I, Borrell-Pagès M, Boada M, Montaner J.Neuronal TIMP-1 release accompanies astrocytic MMP-9 secretion and enhances astrocyte proliferation induced by betaamyloid 25-35 fragment. J Neurosci Res. 2009;87(9):2115-25. 54) Anna Rosell*, Ken Arai, Josephine Lok, Tongrong He, Shu-zhen Guo, Miriam Navarro, Joan Montaner, Zvonimir Katusic, Eng H. Lo*. Interleukin 1-beta augments angiogenic responses of murine endothelial progenitor cells (EPCs) in vitro. J Cereb Blood Flow Metab. 2009;29(5):933-43. *corresponding author. 55) Eloy Cuadrado, Anna Rosell, Maria Borrell-Pagès, Lidia García-Bonilla, Mar Hernández- Guillamon, Arantxa Ortega-Aznar, Joan Montaner. Matrix Metalloproteinase 13 is present in the cell nucleus and is activated after cerebral ischemia. J Cereb Blood Flow Metab. 2009;29(2):398410. 56) Anna Rosell, Christian Foerch, Yoshihiro Murata, Eng H. Lo. Mechanisms and Markers for Hemorrhagic Transformation after Stroke. Acta Neurochir Suppl. 2008;105:173-8. 57) Lok J, Sardi SP, Guo S, Besancon E, Ha DM, Rosell A, Kim WJ, Corfas G, Lo EH. Neuregulin-1 signaling in brain endothelial cells. J Cereb Blood Flow Metab. 2009;29(1):39-43. 58) Wang X, Rosell A, Lo EH. Targeting extracellular matrix proteolysis for hemorrhagic complications of tPA stroke therapy. CNS Neurol Disord Drug Targets. 2008;7(3):235-42. IF: 3.77 59) Anna Rosell*, Eng H. Lo*. Multiphasic Roles for Matrix Metalloproteinases after Stroke. Curr Opin Pharmacol. 2008;8(1):82-9. *corresponding author. 60) Eloy Cuadrado, Laura Ortega, Mar Hernández-Guillamon, Anna Penalba, Israel Fernández- Cadenas, Anna Rosell, Joan Montaner. Tissue plasminogen activator (t-PA) promotes neutrophil degranulation and MMP-9 release. J Leukoc Biol. 2008; 84(1):207-14. Curriculum Vitae, Anna Rosell Novel 61) Yoshihiro Murata, Anna Rosell, Robert Scannevin, Kenneth Rhodes, Xiaoying Wang, Eng H. Lo. Extension of the Thrombolytic Time Window with Minocycline in Experimental Stroke. Stroke, 2008 39(12):3372-7. 62) Anna Vilalta, Juan Sahuquillo, Anna Rosell, Maria A. Poca, Marilyn Riveiro, Joan Montaner. Moderate and severe traumatic brain injury induces early overexpression of systemic and brain gelatinases. Intensive Care Med. 2008 Aug;34(8):1384-92. 63) Pilar Delgado, Eloy Cuadrado, Anna Rosell, José Alvarez-Sabin, Arantxa Ortega-Aznar, Mar Hernandez-Guillamon, Anna Penalba, Carlos A Molina, and Joan Montaner. Fas system activation in perihematomal areas after spontaneous intracerebral hemorrhage. Stroke. 2008;39(6):1730-4. 64) Rosell A, Cuadrado E, Ortega-Aznar A, Hernández-Guillamon M, Lo EH, Montaner J. MMP- 9-positive neutrophil infiltration is Associated to BBB Breakdown and Basal Lamina type IV Collagen Degradation during Hemorrhagic Transformation after Human Ischemic Stroke. Stroke. 2008;39(4):1121-6. 65) Joan Montaner, Mila Perea-Gainza, Pilar Delgado, Marc Ribó, Pilar Chacón, Anna Rosell, Manolo Quintana, Mauricio E. Palacios, Carlos A. Molina, José Alvarez-Sabín. Etiologic Diagnosis of Ischemic Stroke Subtypes Using Plasma Biomarkers. Stroke. 2008; 39(8):2280-7. 66) Navarro M, Rosell A, Hernández-Guillamon M, Cuadrado E, Montaner J. Potencial terapéutico de las Células Progenitoras Endoteliales (CEPs) en el Ictus Isquémico. Rev Neurol. 2007;45(9):556-62. 67) Seong-Ryong Lee, Josephine Lok, Anna Rosell, Hahn-Young Kim, Yoshihiro Murata, Dmitriy Atochin, Paul L. Huang, Xiaoying Wang, Cenk Ayata, Michael A. Moskowitz, Eng H. Lo. Reduction of Hippocampal Cell Death and Proteolytic Responses in Tissue Plasminogen Activator Knockout Mice after Transient Global Cerebral Ischemia. Neuroscience. 2007;150(1):50-57. 68) A. Rosell, E. Cuadrado, J. Alvarez-Sabín, M. Hernandez-Guillamon, P. Delgado, A. Penalba, M. Mendioroz, A. Rovira, I. Fernández-Cadenas, M. Ribó, C.A. Molina, J. Montaner. Caspase-3 Is Related to Infarct Growth after Human Ischemic Stroke. Neurosc Lett. 2008;430(1):16. Curriculum Vitae, Anna Rosell Novel 69) Fernandez-Cadenas I, Alvarez-Sabin J, Ribo M, Rubiera M, Mendioroz M, Molina CA, Rosell A, Montaner J. Influence of thrombin-activatable fibrinolysis inhibitor and plasminogen activator inhibitor-1 gene polymorphisms on tissue-type plasminogen activator-induced recanalization in ischemic stroke patients. J Thromb Haemost. 2007; 9:1862-1868. 70) Cuadrado E, Rosell A, Álvarez-Sabín J, Montaner J. Captura por microdisección láser: una nueva herramienta para el estudio de la isquemia cerebral. Rev Neurol. 2007;44(9):551-5. IF: 1.18 71) Allard L, Turck N, Burkhard PR, Walter N, Rosell A, Gex-Fabry M, Hochstrasser DF, Montaner J, Sanchez JC. Ubiquitin fusion degradation protein 1 as a blood marker for the early diagnosis of ischemic stroke. Biomarker Insights. 2007; 2:155–164. 72) Delgado P, Álvarez Sabin J, Santamarina E, Molina CA, Quintana M, Rosell A, Montaner J. Blood S100b Level After Acute Spontaneous Intracerebral Hemorrhage. Stroke. 2006;37(11):28379. 73) Tejima E, Zhao BQ, Kiyoshi Tsuji, Rosell A, van Leyen K, Montaner J, Wang X, Lo EH. Astrocytic induction of matrix metalloproteinase-9 and edema in intracerebral hemorrhage. J Cereb Blood Flow Metab. 2007;27(3):460-8. 74) Rosell A, Ortega-Aznar A; Alvarez-Sabín J; Fernandez-Cadenas I; Ribó M; Molina CA; Lo EH; Montaner J. Increased Brain Expression of Matrix Metalloproteinase-9 Following Ischemic and Hemorrhagic Human Stroke. Stroke. 2006;37:1399-1406. 75) Delgado P, Alvarez-Sabin J, Abilleira S, Santamarina E, Purroy F, Arenillas JF, Molina CA, Fernandez-Cadenas I, Rosell A, Montaner J. Plasma d-dimer predicts poor outcome after acute intracerebral hemorrhage. Neurology. 2006;67(1):94-8. 76) Joan Montaner, Israel Fernandez-Cadenas, Carlos A Molina, Marc Ribo, Rafael Huertas, Anna Rosell, Anna Penalba, Laura Ortega, Pilar Chacon, and Jose Alvarez-Sabin. Post-stroke Creactive protein is a powerful prognostic tool among candidates for thrombolysis. Stroke. 2006:37:1205-1210. 77) Fernández-Cadenas I, Molina C.A., Alvarez-Sabín J, Ribó M, Penalba A, Ortega-Torres L, Delgado P, Quintana M, Rosell A, Montaner J. ACE gene polymorphisms influence t-PA-induced brain vessel reopening following ischemic stroke. Neuroscience letters 2006;398(3):167-71. Curriculum Vitae, Anna Rosell Novel 78) Fernández-Cadenas I, Alvarez-Sabín J, Molina C.A., Ribó M, Rosell A, Penalba A, Ortega- Torres L, Montaner J. The influence of ApoE genotype on efficacy and safety of thrombolytic treatment for ischemic stroke. Neurología 2006; 21(4):176-180. 79) Rosell A, Alvarez-Sabín J, Arenillas JF, Rovira A, Delgado P, Fernández-Cadenas I, Penalba A, Molina CA, Montaner J. A Matrix Metalloproteinase Protein Array Reveals a Strong Relation between MMP-9 and MMP-13 with Diffusion-Weighted Image Lesion Increase in Human Stroke. Stroke. 2005; 36(7): 1415-20. 80) Turu MM, Krupinski J, Catena E, Rosell A, Montaner J, Rubio F, Alvarez-Sabin J, Cairols M, Badimon L. Intraplaque MMP-8 levels are increased in asymptomatic patients with carotid plaque progression on ultrasound. Atherosclerosis. 2006;187(1):161-9. 81) Arenillas JF, Alvarez-Sabin J, Montaner J, Rosell A, Molina CA, Rovira A, Ribo M, Sanchez E, Quintana M. Angiogenesis in symptomatic intracranial atherosclerosis: predominance of the inhibitor endostatin is related to a greater extent and risk of recurrence. Stroke. 2005;36(1):92-7. 82) Rosell A*, Montaner J, Álvarez Sabín J. Implicación de la angiogénesis en la isquemia cerebral humana. [Angiogenesis in Human Cerebral Ischemia]. 2004. Rev Neurol 38(11):1076. BOOKS (Chapters) - Anna Rosell, Lidia Garcia-Bonilla. Ataque isquémico transitorio: Patofisiología y Modelos de AIT. Montaner J (Editor). Marge Editorial, Barcelona. 2009. - Navarro M, Rosell A. Tratamiento del Ictus Isquémico: Potenciando angio-neurogénesis con factores de crecimiento. Montaner J (Editor). Marge Editorial, Barcelona. 2009. - Rosell A, Lo EH, Wang X. Role of Matrix Metalloproteinases after Stroke: from basic research to clinical impact. In: Jin K and Yang GY, eds. Experimental stroke. Bentham Science. Publishers. 2008. - Rosell A. Fisiopatología de la Isquemia Cerebral: Modelos in vivo e in vitro de isquemia cerebral. Montaner J (Editor). Marge Editorial, Barcelona. 2008. - Rosell A, Ning MM, Wang X, Montaner J, Lo EH. The neurovascular Unit. Montaner J (Editor). Marge Ed., Barcelona. 2008. Curriculum Vitae, Anna Rosell Novel - Montaner J, Rosell A. Biomarkers. Arboix A (Editor). Métodos Diagnósticos en las Enfermedades Vasculares Cerebrales, 2nd edition. Ed. Ergon, Madrid. 2006. DOCTORAL THESIS DIRECTOR - Neurorepair and neurorehabilitation therapies after cerebral ischemia PhD Student: Marina Gabriel Faculty: Neurosciences - Year: ongoing, started in 2015 Neuroprotection and Neurorepair Treatments for Ischemic Stroke PhD Student: Feifei Ma Faculty: Neurosciences - University: Universitat Autònoma de Barcelona, Spain University: Universitat Autònoma de Barcelona, Spain Year: November 30th 2015 (Excellent, cum laude) Magnetic nanoparticles suspensions for cell tracking, imaging and therapeutics in ischemia treatments PhD Student: Elisa Carenza Faculty: Physics - University: Universitat Autònoma de Barcelona, Spain Year: July 11th 2014 (Excellent, cum laude). Neurorepair Treatments for Cerebral Ischemia using Endothelial Progenitor Cells (EPCs). PhD Student: Anna Morancho Retana Faculty: Medicine - University: Universitat Autònoma de Barcelona, Spain Year: April 4th 2014 (Excellent, cum laude). Influence of Endothelial Progenitor Cells on spatial and temporal modulation of Angiogenesis and Vasculogenesis following human ischemic stroke. PhD Student: Miriam Navarro Sobrino Faculty: Medicine - University: Universitat Autònoma de Barcelona, Spain Year: July 29th 2010 (Excellent, cum laude). Matrix Metalloproteinases in cerebral ischemia: cellular origin and tissue damage contribution. PhD Student: Eloy Cuadrado Godia University: Universitat Autònoma de Barcelona, Spain Faculty: Medicine Year: March 3rd 2009 (Excellent, cum laude). MASTER AND UNDERGRADUATE STUDENTS - Sandra Castanyer. Master in Translational Biomedical Research. Vall d’Hebron Research Curriculum Vitae, Anna Rosell Novel Institute, Unviersitat Autònoma de Barcelona, Spain (2015-2016). - Irene Anton Salas. Master in Biomedical Research. Unviersitat Pompeu Fabra, Barcelona, Spain (2015-2016). - Esperanza Medina. Master in Translational Biomedical Research. Vall d’Hebron Research Institute, Unviersitat Autònoma de Barcelona, Spain (2014-2015). - Pablo Martínez San Segundo: Master in Neuroscience. Universitat Autònoma de Barcelona, Spain (2013-2014). - Marina Gabriel Salazar: Master in Neuroscience. Universitat Autònoma de Barcelona, Spain (2012-2013). - Joan Gibert Fernández: Master Biochemistry, molecular biology and biomedicine. Universitat Autònoma de Barcelona, Spain (2011-2012). - Ting Ting Li. Undergraduate Student. Biochemistry, UAB, (2013-2014). - Tiffany Oña Jodar. Undergraduate Student. Biomedicine, UAB,(2013-2014). - Irati Caballero Bermejo. Undergraduate Student. Biology, UAB, (2013-2014). JOURNAL EXTERNAL REVIEWER Acta Biomaterialia (since 2013) Cell Transplantation (since 2015) Circulation (since 2014) Coronary Artery Disease (since 2009) Endocrine (since 2015) European Journal of Neurology (since 2014) Expertise Opinion in Pharmacology (since 2009) Frontiers in Bioscience (since 2009) Heart (since 2011) International Journal of Nanomedicine (since 2015) Journal of Cerebral Blood Flow and Metabolism (since 2011) Curriculum Vitae, Anna Rosell Novel Journal of Neurochemistry (since 2013) Journal of Neuroinflammation (since 2011) Journal of Neuroscience Research (since 2009) Journal of Translational Medicine (since 2012) Neuroscience (since 2009) Neuroscience letters (since 2014) PLoS ONE (since 2011) Scientific Reports (since 2015) Stem Cell Research & Therapy (since 2015) Stroke (since 2007) The International Journal of Neuroscience (since 2011) The Tohoku Journal of Experimental Medicine (since 2010) Translational Stroke Research (since 2014) REVIEWER FOR FUNDING AGENCIES - Czech Science Foundation, Czech Republic. Science research projects, 2015. - ANEP (Agencia Nacional de Evaluacion y Prospectiva), Ministry of Economy and Competitiveness, Spain. MINECO research Projects 2014. - Biomedicine Research Grants. Consejería de Salud de la Junta de Andalucía, Spain. 2011, 2012, 2013, 2014. - Short-Term fellowships, follow-up. Consejería de Salud de la Junta de Andalucía, Spain. 2012. TRIBUNAL THESIS MEMBER - Verónica Guirao Salguero. “Intervención sobre la señalización de receptores extrasinápticos y sinápticos de N-metil-D-aspartato en la muerte neuronal excitotóxica”. Universitat de Barcelona, January 19th 2015. - Violeta Gómez Rodríguez. “Role of Matrix Metalloproteinase-10 after hindlimb ischemia”. Universidad de Navarra, February 27th 2015. Curriculum Vitae, Anna Rosell Novel Isaac García de Yébenes Castro. “Transformación hemorrágica en el ictus isquémico: - desarrollo de un modelo experimental y efecto de la sobrecarga de hierro". Universidad Complutense de Madrid, July 22nd 2014. INVITED SPEAKER - Estudio SMARTS (Studying Markers of Angiogenesis during Rehabilitation Therapy after Stroke): Study Design and Preliminary Results. Annual Meeting of the Spanish Society of Rehabilitation and Physical Medicine (SERMEF). Cádiz, Spain, June 11th 2015. - Biomarkers of angiogenesis and brain plasticity after Stroke. Annual Meeting of the Spanish Society of Rehabilitation and Physical Medicine (SERMEF). Bilbao, Spain, May 8th 2014. - "Modelling Neurorepair Strategies for Stroke: more than progenitor cells". Radiology and Neurology Seminars; Massachusetts General Hospital, Boston, USA. August 2013. - Modeling Cerebrovascular Diseases Course. Modeling Neurorepair strategies: more than stem cells. 15-16 March 2013, Kuopio, Finland. - Endothelial Progenitor Cells: Therapeutic Targets and Markers for vascular repair and angiogenesis. 5th International Conference on Intracranial Atherosclerosis. October 4-6, 2011; Valladolid, Spain. INVITED PARTICIPATION IN MEETINGS - Session chair at the XXVIth BRAIN Meeting. Shanghai, China, May 2013. - Abstract reviewer for the XXVIIth BRAIN Meeting. Vancouver, Canada, 2015 - Abstract reviewer for the 20th International Stroke Conference. Los Angeles, CA, USA, 2016. PARTICIPATION IN TEACHING ACTIVITIES - Master in Translational Medical Research: Neurorepair strategies for Stroke Disease; 2014, Vall d’Hebron Research Institute, Universitat Autònoma de Barcelona, Spain. - Master in Clinical Investigation: Analysis of hypothesis and Objectives, 2012 and 2013. Universitat Autònoma de Barcelona, Spain. Curriculum Vitae, Anna Rosell Novel - Methods for research in cerebrovascular patologies: in vivo and in Vitro models. Curso de estrategias frente al ictus en extremadura: investigación frente al ictus. Consejería de Sanidad y Dependencia. Junta de Extremadura, Spain. 2010. - In vivo models of cerebral ischemia. V Applied neurovascular research course. Hospital Vall d’Hebron. Course from Universitat Autònoma de Barcelona. 2009. - Studies on Matrix Metalloproteinases after Stroke. IV Applied neurovascular research course. Hospital Vall d’Hebron. Course from Universitat Autònoma de Barcelona. 2006. - Human Cerebral Ischemia: Studies in human brain parenchyma. III Applied neurovascular research course. Hospital Vall d’Hebron. Course from Universitat Autònoma de Barcelona. 2005. - Angiogenesis Modulation. Transient Cerebral Ischemia Course. Course from the Universitat Autònoma de Barcelona. 2005. - Laboratory techniques on angiogenesis. II Applied neurovascular research course. Hospital Vall d’Hebron. Course from Universitat Autònoma de Barcelona. 2004. - Angiogenesis Modulation. Transient Cerebral Ischemia Course. Course from Universitat Autònoma de Barcelona. 2003 and 2004. MEMBERSHIPS International Society for Cerebral Blood Flow & Metabolism (ISCBFM) International Scociety for Cell Therapy (ISCT) PATENTS TITLE: Endothelial progenitor cells labelled with superparamagnetic iron oxide micro and nanoparticles in cerebrovascular disorders, process for their preparation and uses thereof. INVENTORS: Anna Rosell Novel, Joan Montaner Villalonga, Anna Roig Serra REQUEST NO.: EP 11382104.5 PRIORITY COUNTRY: Europe (12707793.1) and US (14/110,532) ENTITY: Institut de Recerca Hospital Universitari Vall d'Hebron and Consejo Superior de Investigaciones Científicas. Curriculum Vitae, Anna Rosell Novel TITLE: Method of predicting the evolution of a patient suffering of a neurovascular disease. INVENTORS: Joan Montaner Villalonga, Anna Rosell Novel, Miriam Navarro Sobrino REQUEST NO.: EP11382047.6 PRIORITY COUNTRY: European Patent PRIORITY DATE: 22 February 2011, PCT PCT/EP2012/052876 20/02/2012 ENTITY: Institut de Recerca Hospital Universitari Vall d'Hebron LICENCE: PROMAG, Spain. 2015. TITLE: Methods for determining the propensity of a patient for hemorrhagic transformation after stroke. INVENTORS: Joan Montaner Villalonga, Mar Hernández Guillamon, Anna Rosell Novel, Cristina Merino Zamorano. REQUEST NO.: EP13382546.3 PRIORITY COUNTRY: European Patent PRIORITY DATE: December 23th, 2013. ENTITY: Institut de Recerca Hospital Universitari Vall d'Hebron SCIENTIFIC MEETINGS (ATTENDANCE) - XX Annual Meeting of the International Society of Cell Therapy, Paris, April 2014. - 65ª Reunión Anual de la Sociedad Española de Neurología (SEN). Barcelona, Spain. 2013. - XXV International Symposium on Cerebral Blood Flow and Function (BRAIN & Brain PET), May 2013, Shanghai. - 64ª Reunión Annual de la Sociedad Española de Neurología (SEN). Barcelona, Spain. 2012. - I International Symposium on Gene and Cell Therapy. Granada, June 2012. - 8th Neuroscience Congress - FENS Forum, Barcelona, July 2012. - XXI European Stroke Conference, Lisboa, Portugal. May 2012. - 63ª Reunión Annual de la Sociedad Española de Neurología (SEN). Barcelona, Spain. 2011. Curriculum Vitae, Anna Rosell Novel - XXV International Symposium on Cerebral Blood Flow and Function (BRAIN & Brain PET), May 2011, Barcelona. - XIX European Stroke Conference Barcelona, Spain. 25 - 28 May 2010 - XXX Reunión del Grupo Español de Neurotransmisión y Neuroreparación, Burgos, Spain, 2009. - 61ª Reunión Annual de la Sociedad Española de Neurología (SEN). Barcelona, Spain.2009. - 60ª Reunión Annual de la Sociedad Española de Neurología (SEN). Barcelona, Spain.2008. - 9th International Angiogenesis Meeting. Patras, Greece. June, 2008. - XXIII Internacional Symposium on Cerebral Blood Flow and Function (Brain07). Osaka, Japan, 2007. - International Stroke Conference. San Francisco, USA. American Heart Association, February 2007. - 15th European Stroke Conference, Brussels, Belgium. May 2006. - 57ª Reunión Annual de la Sociedad Española de Neurología (SEN). Barcelona, Spain.2005. - 14th European Stroke Conference, Bologna, Italy. May 2005. - XI Congreso Nacional de la Sociedad Española de Neurociencias (SENC). Málaga, Spain, 2005. - 56ª Reunión Annual de la Sociedad Española de Neurología (SEN). Barcelona, Spain.2004. - 55ª Reunión Annual de la Sociedad Española de Neurología (SEN). Barcelona, Spain.2003. SCIENTIFIC MEETINGS (ABSTRACTS) 1. Anna Rosell, Anna Morancho, Xavi Buxó, Deborah Pareto, Joan Montaner, Dolors Giralt, Ana Carrera, Cristina Boada, Núria Llecha-Cano, Alex Rovira, Mª Carmen Martinez, Immaculada Bori, Susana Rodriguez. Study design and preliminary results of the SMARTS study: Studying Markers of Angiogenesis during Rehabilitation Therapy after Stroke. European Stroke Organization conference, April 2015, Glasgow, UK. INTERNATIONAL JOURNAL OF STROKE Special Issue: SI Supplement: 2 Pages: 170-170 Meeting Abstract: ESOC-1481 Volume: 10 Published: APR 2015 2. Feifei Ma, Anna Morancho, Pablo Martínez-San Segundo, Marina Gabriel-Salazar, Verónica Barceló, Dolors Giralt, Joan Montaner, Anna Rosell. Matrix metalloproteinase-13 (MMP-13) Curriculum Vitae, Anna Rosell Novel modulates neuroprotection and neurorepair after cortical ischemia. European Stroke Organization conference, April 2015, Glasgow, UK. INTERNATIONAL JOURNAL OF STROKE Volume: 10 Special Issue: SI Supplement: 2 Pages: 196-197. 3. E. Carenza, O. Jordan, P. Martínez-San Segundo, R. Jirik, Z. Starcuk jr., G. Borchard, A. Rosell, A. Roig. Encapsulation of a growth factor in magnetic polymeric nanocàpsules. Fourth International Conference on Multifunctional, Hybrid and Nanomaterials. March 2015, Sitges, Spain. 4. Anna Rosell, Elisa Carenza, Verónica Barceló, Anna Morancho, Joan Montaner, Anna Roig. Angiogenic performance of magnetized endothelial progenitor cells for neurorepair after stroke. 20th ISCT Annual Meeting - ISCT, Paris, April 2014. Cytotherapy. 2014;16(4, Supplement):S63 5. A. Rosell, A. Morancho, M. Hernández-Guillamon, C. Boada, V. Barceló, D. Giralt, J. Montaner. Cerebral ischemia and matrix metalloproteinase-9 modulate the angiogenic function of endothelial progenitor cells. Brain Meeting, Shangai, May 2013. 6. Elisa Carenza, Verónica Barceló, Anna Morancho, Lisa Levander, Cristina Boada, Anna Laromaine, Joan Gibert, Anna Roig, Joan Montaner, Anna Rosell. Magnetically Labeled Endothelial Progenitor Cells for Cellular Therapy in Brain Ischemia Treatment. 9th International Conference on Scientific and Clinical Applications of magnetic carriers, Mineapolis, USA. May 2012. 7. Anna Rosell, Elisa Carenza, Verónica Barceló, Lisa Levander, Cristina Boada, Anna Roig, Joan Montaner. Angiogenic Performance of Magnetized Endothelial Progenitor Cells for Neurorepair Therapies. Cerebrovascular Diseases, 2012. 8. Anna Morancho, Joan Gibert, Cristina Boada, Verónica Barceló, Laura Ortega, Anna Penalba, Mar Hernández-Guillamon, Joan Montaner, Anna Rosell. Cerebral Ischemia and Matrix Metalloproteinase-9 (MMP-9) Modulate the Angiogenic Function of Endothelial Progenitor Cells (EPC). Cerebrovascular Diseases, 2012. 9. Morancho Retana, Anna; Boada Llamas , Cristina; Ortega Torres, Laura; Penalba Morenilla, Anna; Giralt Casellas, Dolors; Barceló Romero, Verónica; Hernández Guillamon, Mar; Montaner Villalonga, Joan ; Rosell Novel, Anna. Modulación del nicho neurovascular y de la función angiogénica de las células endoteliales progenitoras por la isquemia cerebral y la metaloproteinasa- Curriculum Vitae, Anna Rosell Novel 9. SEN 2011. Neurología;26:47. 10. Domingues-Montanari, Sophie; del Rio Espinola, Alberto ; Penalba Morenilla, Anna ; Rubiera, Marta; Ribó, Marc; Rosell, Anna; Alvarez-Sabin, Jose; Fernández-Cadenas, Israel; Montaner, Joan. Asociación acumulativa de seis variantes en los genes KCNK17, LRP, NOS3, SCNN1A y MMP12 con el ictus isquémico. SEN 2011. Neurología;26:50. 11. García Berrocoso, Teresa; Penalba Morenilla, Anna; Boada Llamas, Cristina; Giralt Casellas, Dolors; Ribó Jacobi, Marc; Molina Cateriano, Carlos; Álvarez Sabín, José ; Rosell Novel, Anna; Montaner Villalonga, Joan. Estudio global del papel de las quimiocinas en la unidad neurovascular y a nivel perifèrico tras la isquèmia cerebral humana. Neurología;26:49. 12. Carenza Elisa, Rosell Anna, Lavander Lisa, Barceló Verónica, Montaner Joan, Roig Anna. Anionic magnetic nanoparticles for cellt racking. Nanomedicine 2011, European science fundation, Lutherstadt Wittenberg, Germany. 13. Morancho, Anna; Rosell, Anna; García, Sandra; Giralt, Dolors; Barceló, Veronica; Montaner, Joan. A new mouse model of focal transient cerebral ischemia by distal occlusion of the middle cerebral artery. Brain meeting. JCBFM; 2011. 14. Morancho, Anna; Rosell, Anna; Navarro-Sobrino, Miriam; Martínez-Saez, Elena; García- Bonilla, Lídia; García, Sandra; Barceló, Veronica; Penalba, Anna; Lope-Piedrafita, Sílvia; Montaner, Joan. Administration of endothelial progenitor cells or their secreted factors enhances the neuroangiogenic responses in a mice model of cerebral ischemia. Brain meeting. JCBFM; 2011. 15. Mireia Campos, Lidia García-Bonilla, Dolors Giralt, David Salat, Pilar Chacón, Anna Rosell, Joan Montaner. Evidence for the efficacy of statins in animal stroke models: a meta-analysis. Brain meeting. JCBFM; 2011. 16. Montaner, J; Penalba, A; Chacon, P; Delgado, P; Rosell, A; Ribo, M; Giralt, D; Quintana, M; Flores, A; Garcia-Berrocoso, T; Boada, C; Molina, C; Fernandez-Cadenas, I; Alvarez-Sabin, J. Discovery of a New Panel of Blood Biomarkers to Differentiate Acute Stroke from Stroke-Mimicking Conditions. International Stroke Conference, FEB 08-10, 2011 Los Angeles, CA. Stroke 2011; 42 (3): E145. 17. Domingues-Montanari S, Fernandez-Cadenas I, del Rio-Espinola A, Mendioroz M, Delgado Curriculum Vitae, Anna Rosell Novel P, Penalba A, Rubiera M, Ribo M, Rosell A, Alvarez-Sabin J, Montaner J. Cumulative Association of Six Variants in the KCNK17, LRP, NOS3, SCNN1A and MMP12 Genes with Ischemic Stroke. International Stroke Conference, FEB 08-10, 2011 Los Angeles, CA. Stroke 2011; 42 (3): E186. 18. Morancho, Anna; Rosell, Anna; Navarro-Sobrino, Miriam; Martínez-Saez, Elena; García- Bonilla, Lídia; García, Sandra; Barceló, Veronica; Penalba, Anna; Lope-Piedrafita, Sílvia; Montaner, Joan. La Administración de las células endoteliales progenitoras o de sus factores de secreción potencia las respuestas neuroangiogénicas en un modelo de isquemia cerebral en ratón. Neurología. 2010; 25 :1-112. 19. I. Fernández-Cadenas, S. Domingues-Montanari, A. del Río-Espínola, M. Mendioroz, L. Deu, C. Nafria, P. Delgado, C.A. Molina, A. Rosell, J. Álvarez-Sabín y J. Montaner. Polimorfismos asociados con infarto de miocardio, fibrilación auricular y obesidad son factores de riesgo genético de ictus isquémico en una cohorte de 1.080 sujetos. Neurologia, 2010; 25 :1-112. 20. M. Hernández-Guillamón, P. Delgado, S. Domingues-Montanari, A. Masot, O. Maisterra, M. Parés, A. Penalba, C. Boada, A. Ortega-Aznar, J. Álvarez-Sabín, A. Rosell, M. Boada, J. Montaner. Niveles de MMP-2 en cerebro y en plasma de pacientes con hemorragia intracerebral asociada a angiopatia cerebral amiloide. Neurologia, 2010; 25 :1-112. 21. Navarro-Sobrino M, Rosell A, Hernández-Guillamón M, Penalba A, Boada C, Massot A, Alvarez-Sabín J, Montaner J. A large screening of angiogenesis biomarkers reveals an association with neurological outcome after ischemic stroke. Cerebrovascular Disease 2010; 22. Parés M., Hernández-Guillamón M., Ortega L., Navarro-Sobrino M., Boada C., Couraud P. O., Ribó M., Rosell A., Montaner J. rtPA enhances OGD-induced cell death and Gelatinases release in brain endothelial cells. Cerebrovascular Disease 2010; 23. Fernández-Cadenas, I.; Del Río-Espínola, A.; Domingues-Montanari, S.; Mendioroz, M.; Delgado, P.; Fernández-Morales, J.; Penalba, A.;Ribó, M.; Rubiera, M.; Maisterra O.; Rosell, A.; Molina CA.; Alvarez-Sabin J.; Montaner, J. Study of the transcriptomic pattern of cardioembolic ischemic stroke. New strategies for stroke etiology biomarkers discovery . Cerebrovascular Disease 2010; 24. Sophie Domingues-Montanari, Israel Fernández-Cadenas, Alberto del Rio-Espinola, Maite Curriculum Vitae, Anna Rosell Novel Mendioroz, Jessica Fernández-Morales, Pilar Delgado, Anna Penalba, Pilar Chacón, David Salat, Marc Ribó, Anna Rosell, José Álvarez-Sabín, Joan Montaner. The I/D polymorphism of the Ace1 is not a risk factor for ischemic stroke. Cerebrovascular Disease 2010; 25. Dolors Giralt, Lidia García-Bonilla, Mireia Campos, Vicky Sosti, Anna Rosell, Joan Montaner. Selecting the optimal dose of citicholine treatment in animal models of focal ischemia. Through a meta-analysis. Cerebrovascular Disease 2010; 26. Delgado P, Penalba A, Chacón P, Pelegrí D, García-Berrocoso T, Giralt D, Salat D, Rubiera M, Molina CA, Álvarez-Sabín J, Rosell A, Montaner J. Lipoprotein-associated phospholipase A2 (Lp-PLA2) mass and activity may influence early vascular recurrence in transient ischemic attack patients. Cerebrovascualr Disease 2010; 27. Domingues-Montanari, S; Fernandez-Cadenas, I; del Rio-Espinola, A; Mendioroz, M; Fernandez-Morales, J; Delgado, P; Penalba, A; Chacon, P; Salat, D; Ribo, M; Rosell, A; Montaner, J. Association of Five Variants in the LRP, NOS3, SCNN1A and MMP12 Genes With Ischemic Stroke. International Stroke Conference, FEB 23-26, 2010 San Antonio, TX. Stroke 2010; 41(4):E241. 28. Giralt D, Garcia-Bonilla L, Mendioroz M, Domingues-Montanari S, Rosell A, Montaner J. Effect of Citicoline Treatment in Animal Models of Focal Cerebral Ischemia: A Systematic Review and Meta-analysis. International Stroke Conference, FEB 23-26, 2010 San Antonio, TX. Stroke 2010; 41(4):E278. 29. Massot Tarrús A; Pelegrí D; Penalba Morenilla A; Arenillas Lara J.F; Boada C; Giralt D; Ribó Jacobí M; Molina Cateriano C; Alvarez-Sabín J; Chacón P; García Berrocoso T; Delgado Martínez P; Rosell Novel A; Montaner J. Lp-PLA2 en pacientes con enfermedad ateroesclerótica intracraneal sintomática. Neurología 2009; 24(8):680. 30. García Berrocoso T; Rosell Novel A; Cuadrado Godia E.; Fernández Cadenas I; Delgado Martínez P; Ribó Jacobi M; Hernández Guillamon M; Ortega Aznar A; Montaner J. Perfil génico del perihematoma cerebral humano tras la hemorragia intracraneal espontánea. Neurología 2009; 24(8):555. 31. Montaner J, Hernández-Guillamón M, Solé M, Parés M, Cuadrado E, García-Bonilla L, Curriculum Vitae, Anna Rosell Novel Rubiera M, Ribó M, Molina C, Álvarez-Sabín J, Rosell A, Unzeta M. Vascular adhesion protein-1 (VAP-1/SSAO) is involved in intracranial hemorrhagic complications after thrombolysis in human stroke. Cerebrovasc Dis 2009;27(suppl 6):57 32. Massot A, Pelegrí D, Penalba A, Arenillas J, Boada C, Giralt D, Ribó M, Molina C, Álvarez- Sabín J, Chacón P, García T, Delgado P, Rosell A, Montaner J. LP-PLA2 testing usefulness among patients with symptomatic intracranial atherosclerotic disease. Cerebrovasc Dis 2009;27(suppl 6):222 33. Domingues-Montanari S, Fernández-Cadenas I., Del Río-Espínola A, Mendióroz M, Fernández-Morales J, Delgado P, Penalba A, Chacón P, Salat D, Ribó M, Rosell A, Montaner J. Riesgo genético asociado a ictus isquémico: Estudio de 250 polimorfismos en 1.080 casos y controles. Neurología 2009; 24(8):532. 34. Fernández-Cadenas I, Fernández-Morales J, del Rio-Espinola A, Mendioroz M, Domingues- Montanari S, Delgado P, Penalba A, Ribo M, Rubiera M, Maisterra O, Molina CA, Rosell A, Montaner J. Study of the transcriptomic pattern of ischemic stroke patients with hemorrhagic transformation after t-pa administration. a microarray analysis. Cerebrovasc Dis 2009;27(suppl 6):45 35. Domingues-Montanari S, Fernández-Cadenas I, del Rio-Espinola A, Mendioroz M, Fernández-Morales J, Delgado P, Penalba A, Chacón P, Salat D, Ribó M, Rosell A, Montaner J. Predicting the genetic risk of ischemic stroke: study of 250 polymorphisms in 1.080 cases and controls. Cerebrovasc Dis 2009;27(suppl 6):30 36. García-Bonilla L, Sosti V, Hernández-Guillamón M, Rosell A, Montaner J.Dipyridamole confers protection following acute focal cerebral ischemia in the rat. Cerebrovasc Dis 2009;27(suppl 6):21 37. Fernandez-Cadenas I, Fernandez-Morales J, del Río-Espinola A, Mendioroz M, Domingues- Montanari S, Penalba A, Ribó M, Rubiera M, Delgado P, Maisterra O, Rosell A, Molina CA, AlvarezSabín J, Montaner J. Studying the Transcriptomic Pattern of the 30,000 genes Among Stroke Patients with Hemorrhagic Transformation Post-tPA. Stroke 2009;40 (4): e110 38. Anna Rosell, Eloy Cuadrado, Israel Fernández-Cadenas, Pilar Delgado, Teresa García, Marc Ribó, Mar Hernández-Guillamon, Arantxa Ortega-Aznar, Joan Montaner. Brain perihematoma Curriculum Vitae, Anna Rosell Novel gene profile following spontaneous human intracerebral hemorrhage. JCBFM, Brain meeting. JCBFM; 2009, 29: S509. 39. Lidia García-Bonilla, Victoria Sosti , Mar Hernández-Guillamon , Anna Rosell and Joan Montaner. Dypiridamole confers protection in acute focal cerebral sichemia in the rat. Brain meeting. JCBFM; 2009, 29: S176. 40. Joan Montaner, Mar Hernández-Guillamon, Montse Solé, Mireia Parés, Tony Valente, Eloy Cuadrado, Lidia Garcia-Bonilla, Marta Rubiera, Marc Ribó, Carlos A. Molina, José Alvarez-Sabín, Anna Rosell, Mercedes Unzeta. Vascular adhesion protein-1 (VAP-1/SSAO) is involved in intracranial hemorrhagic complications after thrombolysis in human stroke. JCBFM, Brain meeting. JCBFM; 2009, 29: S416. 41. Miriam Navarro, Anna Rosell, Mar Hernández-Guillamon, Anna Penalba, Laura Ortega, Marc Ribó, Eloy Cuadrado, Andreu Massot, Pilar Delgado, José Alvarez-Sabín, Joan Montaner. Movilización aguda de EPCs con mayor diferenciación endotelial en la fase subaguda del ictus isquemico. Neurología, 2008. 42. A. del Río-Espínola, M. Quintana, S. Domingues-Montanari, M. Mendióroz, A. Rosell, A. Penalba, V. Obach, J. Serena, J. Martí, M. Mar Freijo, E. Santamarina, C. Molina, J. Álvarez-Sabín, I. Fernández- Cadenas, J. Montaner.Regulación genética y genómica de la MMP-9 en pacientes con ictus isquémico con transformación hemorrágica tras tratamiento fibrinolítico. Neurología 2008. 43. L. Ortega-Torres, J. Alvarez-Sabín, C. Domínguez, M. Ribó, A. Rovira, M. Rubiera, P. Delgado, O. Maisterra, R. Delgado-Mederos, M. Quintana, C.A. Molina, I. Fernández-Cadenas, A. Rosell, J. Montaner. El efecto deletéreo de la hiperglicemia durante la isquemia cerebral está asociado a incrementos de estrés oxidativo (MDA) y proteolisis (MMP-9) seguidos de crecimiento en el volumen de infarto (DWI). Neurología 2008. 44. I. Fernández-Cadenas, J. Fernández-Morales, A. del Río-Espinola, M. Mendioroz, S. Domingues-Montanari, A. Penalba, M. Ribó, M. Rubiera, P. Delgado, O. Maisterra, A. Rosell, C. Molina, J. Álvarez-Sabín, J. Montaner. Estudio del patrón transcriptómico de los 30.000 genes del genoma en pacientes con transformación hemorrágica post-tPA. Neurología 2008. 45. Miriam Navarro, Anna Rosell, Mar Hernández-Guillamon, Marc Ribó, Eloy Cuadrado, José Curriculum Vitae, Anna Rosell Novel Alvarez-Sabín, Joan Montaner. Endothelial Progenitor Cell Levels and Endothelial Differentiation in Ischemic Stroke Patients. 9th International Angiogenesis meeting; Patras, Greece, 2008. 46. A. Rosell, M. Navarro, J. Lok, K. Arai, J. Montaner, Eng H. Lo. La Interleuquina-1ß mejora la respuesta angiogénica de Células Endoteliales Progenitoras (EPCs) murinas in vitro. Neurología. 2007. 47. Fernández-Cadenas, M. Mendioroz, M. Rubiera, A. del Rio, S. Domingues, M. Ribó, O. Maisterra, A. Rosell, C.A. Molina, J. Álvarez-Sabín, J. Montaner.El polimorfismo 4G5G del PAI-1 está asociado con la reoclusión de la arteria cerebral media tras terapia fibrinolítica en pacientes con ictus isquémico. Neurología. 2007. 48. E. Cuadrado, A. Rosell, A. Ortega, M. Hernández, M. Borrell, L. García-Bonilla, M. Navarro, M. Ribó, C.A. Molina, L. Ortega, J. Alvarez-Sabín, J. Montaner. Identificación de niveles elevados de MMP-13 intranuclear en tejido cerebral humano y murino tras la isquemia cerebral. Neurología. 2007. 49. M. Navarro, A. Rosell, A. Penalba, M. Hernandez, E. Cuadrado, E. Santamarina, M. Rubiera, C. Molina, J. Álvarez-Sabín, J. Montaner. Incremento de los valores plasmáticos de GMSCF tras el ictus isquémico. Neurología. 2007. 50. A. Penalba, L. Ortega, A. Rosell, I. Fdez-Cadenas, E. Cuadrado, L. García-Bonilla, M. Mendioroz, M. Quintana, J. El cambio en la relación TH1/TH2 inducido por simvastatina (TH2 shift) en la fase aguda del ictus se asocia a mejoría neurológica e incremento del riesgo de infecciones. Neurología. 2007. 51. RH. Scannevin, BC. Magliaro, Y. Wang-Fisher, SL. Burke, Z. Huang, A. Rosell, Y. Murata, KI. Carroll, EH. Lo and KJ. Rhodes. Temporal expression patterns of inflammatory molecules in the brain of rats subjected to transient middle cerebral artery occlusion. Neuroscience, 2007. 52. Rosell A, Cuadrado E, Borrell-Pages M, Navarro M, Hernandez-Guillamon M, Penalba A, Ortega L, Montaner J. Appearance of intra-nuclear matrix metalloproteinases is involved in the early stages of neuronal death following brain ischemia. Journal of cerebral blood flow and metabolism, 2007. 53. Murata Y, Rosell A, Wang X, Scannevin RH, Rhodes K, Katayama Y, Lo EH. Efficacy of Curriculum Vitae, Anna Rosell Novel minocycline for delayed tissue plasminogen activator treatment after embolic focal ischemia in rats. Journal of cerebral blood flow and metabolism, 2007. 54. J. Montaner, A. Penalba, I. Fernández-Cadenas, M. Navarro, A. Rosell, E. Cuadrado-Godia, P. Chacón, O. Maisterra, C.A. Molina, J. Alvarez-Sabín. Th1/Th2 shift induced by simvastatin in the acute phase of ischemic stroke is associated with both neurological improvement and increased risk of infections. Cerebrovascular Diseases. 2007. 55. E. Cuadrado, A. Rosell, M. Borrell-Pages, M. Hernandez-Guillamon, A. Penalba, L. Ortega, M. Ribo, C.A. Molina, J. Alvarez-Sabin, J. Montaner. Identification of matrix metalloproteinases in ischemic brain tissue and its intra-nuclear location in both human stroke and mcao rat model. Cerebrovascular Diseases 2007. 56. I. Fernandez-Cadenas, A. Del Rio, J. Alvarez-Sabin, P. Delgado, M. Mendioroz, E. Santamarina, M. Ribo, C.A. Molina, A. Rosell, J. Montaner. mRNA expression level of PAI-1 gene influences revascularisation rates of the middle cerebral artery among ischemic stroke patients treated with t-PA. Cerebrovascular Diseases. 2007 57. Pilar Delgado, Eloy Cuadrado, Anna Rosell, Jose Alvarez Sabin, Arantxa Ortega, Anna Penalba, Mar Hernández, Carlos A Molina, Joan Montaner.Apoptosis Involvement After Human Spontaneous Intracerebral Hemorrhage: Fas System and Caspase-3 in Plasma and Brain Tissue. Stroke, 2007. 58. Joan Montaner, Maite Mendioroz, Israel Fernandez-Cadenas, Marta Rubiera, Esteban Santamarina, Pilar Delgado, Marc Ribo, Anna Rosell, Carlos A Molina, Jose Alvarez-Sabin. Circulating Activated Protein C Level Predicts Reperfusion, Hemorrhagic Transformation, and Mortality Following tPA Treatment in Stroke Patients. Stroke, 2007. 59. E. Cuadrado, A. Rosell, A. Ortega, M. Hernández, P. Delgado, M. Ribó, C.A. Molina, L. Ortega, J. Álvarez-Sabín, J. Montaner. La infiltración de neutrófilos (MMP-9 +) en capilares del core del infarto se relaciona con rotura de la barrera hematoencefálica y transformación hemorrágica en pacientes con ictus isquémico. Neurología, 2006. 60. J. Montaner, A. Rosell, N. Turck, M. Perea-Gainza, N. Corbeto, E. Cuadrado, A. Penalba, C. A. Molina, J. Álvarez-Sabín, J. C. Sánchez. Identificación de nuevos biomarcadores de isquemia Curriculum Vitae, Anna Rosell Novel cerebral mediante técnicas de proteómica. Neurología, 2006. 61. P. Delgado, M. Mendióroz, I. Fernández- Cadenas, A. Rosell, M. Ribó, M. Rubiera, E. Santamarina, C. A. Molina, J. Alvarez-Sabín, J. Montaner. Influencia de los factores de la coagulación endógenos sobre las tasas de recanalización en pacientes con isquemia cerebral tratados con rt-PA. Neurología, 2006. 62. I. Fernández-Cadenas, M.Mendioroz, A.Rosell, A.Penalba, L.Ortega, N.Corbeto, J.Álvarez- Sabín, P.Chacón, J.Montaner.La Dislipemia y los Factores Genéticos influencian la recanalización arterial en pacientes con Ictus Isquémicos tratados con t-PA. CEID 2006. 63. M.Mendioroz, I. Fernández-Cadenas, A Rosell, A.Penalba, L.Ortega, N.Corbeto, J.Álvarez- Sabín, P.Chacón, J.Montaner. Grecos Project: genotyping recurrence risk of stroke. CEID 2006. 64. Rosell A, Alvarez-Sabín J, Ortega-Aznar A, Delgado P, Delgado-Mederos R, Fernández- Cadenas I, Cuadrado E, Ribó M, Molina CA, Montaner J. Deleterious Role of Apoptosis in Human Stroke: Caspase-3 is Related to Poor Neurological Outcome Among t-PA Treated Patients and Activated in the Ischemic Brain. Cerebrovasc Dis 2006. 65. J. Montaner, P. Delgado, M. Ribó, M. Rubiera, M.E. Palacios, C.A. Molina, I. Fernández- Cadenas, A. Rosell, P. Chacón, J. Alvarez-Sabín. Etiologic diagnosis of stroke subtypes using plasma biomarkers. Cerebrovasc Dis 2006. 66. P. Delgado, J. Alvarez-Sabin, A. Rosell, E. Santamarina, S. Abilleira, C. Molina, I. Fernández-Cadenas, L. Ortega, M. Quintana, J. Montaner. Apoptosis involvement after human spontaneous intracerebral hemorrhage: Soluble Fas and caspase-3 in blood and brain tissue. Cerebrovasc Dis 2006. 67. J. Montaner, C. Dominguez, P. Delgado, M. Ribó, E. Santamarina, C. Molina, P. Martín, I. Fernández-Cadenas, A. Rosell, J. Alvarez-Sabín. Biomarkers of oxidative stress following t-PA induced reperfusion in human stroke. Cerebrovasc Dis 2006. 68. Vilalta A, Rosell A, Poca MA, Sahquillo J, Montaner J, Rios JA de los, Riveiro M. Increased levels of matrix metalloprotease-9 in plasma and brain extracellular fluid in the early phase of traumatic brain injury. The 8th International Neurotrauma Symposium, 2006. 69. Montaner J, Delgado P, Ribo M, Purroy F, Rubiera M, Molina CA, Fernandez-Cadenas I, Curriculum Vitae, Anna Rosell Novel Rosell A, Chacón P, Alvarez-Sabín J.Etiologic Diagnosis of Stroke Subtypes Using PlasmaBiomarkers.Stroke.2006. 70. Rosell A, Ortega A, Alvarez-Sabín J, Vilalta A, Fernández-Cadenas I, Ribó M, Molina CA, Sauquillo J, Montaner J. Matrix Metalloproteinase-9 over-expression in human brain tissue after ischemic and hemorrhagic stroke. Neurología. 2005;20:496. 71. Delgado P, Montaner J, Santamarina E, Purroy F, Delgado R, Rosell A, Fernández- Cadenas I, Molina CA, Quintana M, Álvarez-Sabin J. Initial growth speed of spontaneous intracranial hemorrhage predicts neurological outcome at short term. Neurología. 2005; 20:490. 72. Delgado P, Álvarez-Sabín J, Santamarina E, Purroy F, Molina CA, Fernández-Cadenas I, Rosell A, Penalba A, Montaner J. Perihematoma edema growth is related with apoptosis biomarkers (soluble FAS) after spontaneous intracranial hemorrhage. Neurología. 2005;20:490. 73. Fernandez-Cadenas I, Montaner J, , Gonzalez-Conejero R, Iniesta JA ,Vicente V, Corral J, Marti-Fabregas J, Obach V, Millan M , Molina C , Ribo M, Rosell A, Penalba A, Ortega-Torres L, Quintana M, Alvarez-Sabín J. Genetic background in ischemic strokes predicts hemorrhagic transformation and recanalitzation after t-PA treatment. Neurología. 2005;20:473 74. Montaner J, Delgado P, Ribó M, Purroy F, Penalba A, Rosell A, Chacón P, Molina CA, Romero F, Alvarez-Sabín J. A Panel of Biomarkers May Successfully Predict Acute Stroke Diagnosis. Neurología. 2005;20:497. 75. Rosell A, Ortega A, Alvarez-Sabín J, Fernández-Cadenas I, Ribó M, Molina CA, Sahuquillo J, Planas AM, Montaner J. Matrix Metalloproteinase-9 over-expression in human brain tissue and brain microdialysate after ischemic and hemorrhagic stroke. Revista de Neurología. 2005; suppl.2:79. 76. Rosell A, Alvarez-Sabín J, Arenillas J.F, Rovira A, Delgado P, Fernández-Cadenas I, Penalba A, Molina C.A, Montaner J. Metalloproteinase-9 and 13 are strongly related with DiffusionWeighted Image lesion increase and over-expressed into the infarcted core after human stroke. Cerebrovasc Dis 2005;19(suppl 2):34. 77. Delgado P, Alvarez-Sabín J, Ribó M, Purroy F, Rosell A, Penalba A, Fernández-Cadenas I, Arenillas J.F, Molina C.A, Montaner J. Differentiating ischemic and hemorrhagic stroke by means of Curriculum Vitae, Anna Rosell Novel a panel of plasma biomarkers. Cerebrovasc Dis 2005;19(suppl 2):63. 78. Montaner J, Ribo M, Delgado P, Purroy F, Quintana M, Penalba A, Rosell A, Chacon P, Arenillas JF, Molina CA, Alvarez-Sabin J. A Panel of Biomarkers May Successfully Predict Acute Stroke Diagnosis. Stroke. 2005;36:419. 79. Montaner J, Ribó M, Delgado P, Purroy F, Quintana M, Penalba A, Rosell A, Chacon P, Molina C.A, Alvarez-Sabín J. Biochemical diagnosis of acute stroke using a panel of plasma biomarkers. Cerebrovasc Dis 2005;19(suppl 2):47. 80. Montaner J, Rosell A, Delgado P, Ribó M, Purroy F, Penalba A, Fdez-Cadenas I, Molina C, Alvarez-Sabín J. A panel of biomarkers may successfully predict acute stroke diagnosis. Journal of cerebral blood flow and metabolism. 2005. Abstract 127 81. Arenillas JF, Montaner J, Molina CA, Rosell A, Rovira A, Frascheri L, Penalba A, Quintana M, Alvarez-Sabín J. Angiogenesis in symptomatic intracranial large-artery occlusive disease: Vascular Endotelial Growth Factor and Endostatin level are related to disease severity. Stroke 2004;35:317. 82. Montaner J, Molina CA, Arenillas JF, Ribó M, Huertas R, Fernández-Cadenas I, Rosell A, Penalba A, Monasterio J, Alvarez-Sabín J. Proteolytic modifications on the metalloproteinase system (MMP-9-Laminin-TIMP-1) induced by t-PA treatment for acute cerebral ischemia in humans. Stroke 2004;35:339. 83. Arenillas JF, Montaner J, Molina CA, Rosell A, Rovira A, Frascheri L, Penalba A, Quintana A, Alvarez-Sabín J. Angiogenesis in symptomatic intracranial large-artery occlusive disease: vascular endotelial growth factor and endostatin level are related to disease severity. Stroke 2004;35: 317. 84. Arenillas JF, Montaner J, Molina CA, Rovira A, Rosell A, Ribó M, Santamarina E, Penalba A, Quintana M, Alvarez-Sabín J. Angiogenesis in symptomatic intracranial large-artery occlusive disease: vascular endothelial growth factor and endostatin level are related to its extent and risk of recurrence. Cerebrovasc Dis 2004;17(suppl 5):23. 85. Ribó M, Montaner J, Molina CA, Arenillas JF, Rosell A, Chacón P, Alvarez-Sabín J. Admission fibrinolytic profile predicts clot lysis resistance in stroke patients treated with tissue Curriculum Vitae, Anna Rosell Novel plasminogen activator. Cerebrovasc Dis 2004;17(suppl 5):33. 86. Montaner J, Rosell A, Molina CA, Fernández-Cadenas I, Ribó M, Huertas R, Arenillas JF, Penalba A, Monasterio J, Alvarez-Sabín J. Extracellular matrix (MMP-9-laminin-TIMP-1) modifications induced by thrombolytic treatment (t-PA) for acute cerebral ischemia in humans. Cerebrovasc Dis 2004;17(suppl 5):33. 87. Krupinski J, Miguel M, Catena E, Rosell A, Montaner J, Alvarez-Sabín J, Cairols M, Badimón L, Rubio F. Matrix metalloproteinases in patients with advanced carotid atherosclerosis. Cerebrovasc Dis 2004;17(suppl 5): 94. 88. Alvarez-Sabín J, Chacón P, Molina CA, Arenillas JF, Ribó M, Fernández-Cadenas I, Rosell A, Penalba A, Pujadas F, Montaner J. Triflusal is superior to aspirin suppressing the inflammatory response that follows ischemic stroke. Cerebrovasc Dis 2004;17(suppl 5):109. 89. Krupinski J, Miguel M, Catena E, Rosell A, Montaner J, Alvarez-Sabín J, Cairols M, Badimón L, Rubio F. Matrix metalloproteinases in patients with advanced carotid atherosclerosis. Cerebrovasc Dis 2004;17(suppl 5): 94. 90. Rosell A, Montaner J, Molina CA, Arenillas CA, Ribó M, Fernández-Cadenas I, Penalba A, Quintana M, Monasterio J, Alvarez-Sabín J. Hypoperfusion after ischemic stroke increases matrix metalloproteinases and angiogenic factors related to neurological outcome at short and long term. Neurología 2004;19(9):510. 91. Fernández-Cadenas I, Montaner J, Andreu AL, Molina C, Arenillas J, Ribo M, Rosell A, Penalba A, Monasterio J, Quintana M, Alvarez-Sabín J. ACE gene polymorphisms influence t-PAinduced brain vessel reopening following ischemic stroke. Neurología 2004;19(9):515. 92. Rosell A, Montaner J, Molina CA, Arenillas JF, Ribó M, Fernández-Cadenas I, Penalba A, Monasterio J, Alvarez-Sabín J. Angiogenesis in Human Cerebral Ischemia: the angiogenic balance (Endostatin/VEGF) during the hyperacute phase after ischemic stroke is related to neurological outcome at short and long term. Neurología 2003;18:528. 93. Fernández-Cadenas I, Montaner J, Andreu A, Molina C, Arenillas J, Huertas R, Rosell A, Penalba A, Quintana M, Alvarez-Sabín J. Geno-t-PA: safety profile of tissue plasminogen activator treatment among stroke patients carrying a common polymorphism (C-1562T) in the promoter Curriculum Vitae, Anna Rosell Novel region of the matrix metalloproteinase-9 gene. Neurología 2003;18:488. 94. Miguel M, Krupinski J, Montaner J, Catena E, Monasterio J, Rosell A, Rubio F, Cairols M, Alvarez-Sabín J, Badimón L. Matrix Metalloproteinases (MMPs), ¿inflammation and atherosclerosis or cerebral ischemic lesion?. Neurología 2003;18:529.