Francisca Mulero

Transcripción

Francisca Mulero

Simposio Internacional: La
visión computacional se encuentra con la
medicina: presente y futuro de las modalidades de imagen y los
biomarcadores
International Symposium: Computer
Vision meets Medicine: Present and
future of imaging modalities and biomarkers
Madrid, 14 de noviembre de 2016
Madrid, November 14, 2016
CV
FRANCISCA MULERO ANIORTE
Academic degree: MD Doctor in Medicine and Surgery (1986 – 1992).
University of Alicante
Speciality (MIR):
Nuclear Medicine (1993 – 1997) Hospital Virgen de la Arrixaca, Murcia
POSGRATUATE FORMATION
1994-1996: Ph.D Doctorate studies and Investigator Sufficiency. University of Murcia.
1998: Doctoral Thesis: Title: "MIBI-Tc-99m in the differential diagnosis of breast injuries".
Qualification: “Excellent Cum laude”.
CURRENT POSITION
2007-Now: Head, Molecular Imaging Unit at the CNIO (Centro Nacional de
Investigaciones oncológicas)
RESEARCH ARTICLES (since 2005)
- 18F-fluoromisonidazole PET and activity of neoadjuvant nintedanib in early HER2negative breast cancer: a window-of-opportunity randomized trial.
Quintela-Fandino M, Lluch A, Manso LM, Calvo I, Cortes J, García-Saenz JA, Gil JM,
Martinez-Jañez N, González-Martín A, Adrover E, De Andres R, Viñas G, Llombart
Cussac A, Alba E, Guerra J, Bermejo B, Zamora E, Moreno-Anton F, Pernas-Simon S,
Carrato A, Lopez A, Escudero MJ, Campo R, Carrasco EM, Palacios J, Mulero F*,
Colomer R*. *Senior Author. Clin Cancer Res. 2016 Sep 1. pii:clincanres.0738.2016.
[Epub ahead of print]
- Targeting MT1-MMP as an immunoPET-based strategy for imaging gliomas. A.G. de
Lucas, A.J. Schuhmacher, M. Oteo, E. Romero, J.A. Cámara, A. de Martino, A.G. Arroyo,
M. Á. Morcillo, M. Squatrito, J.L. Martinez-Torrecuadrada and F. Mulero. PLOS ONE
2016 in press
- Targeting Tumor Mitochondrial Metabolism Overcomes Resistance to Antiangiogenics.
Navarro P, Bueno MJ, Zagorac I, Mondejar T, Sanchez J, Mourón S, Muñoz J, GómezLópez G, Jimenez-Renard V, Mulero F, Chandel NS, Quintela-Fandino M. Cell Rep. 2016
Jun 21;15(12):2705-18.
FUNDACIÓN RAMÓN ARECES
biomarcadores
CV
- Local delivery of parathyroid hormone-related protein-derived peptides coated onto a
hydroxyapatite-based implant enhances bone regeneration in old and diabetic rats. Ardura
JA, Portal-Núñez S, Lozano D, Gutiérrez-Rojas I, Sánchez-Salcedo S, López-Herradón A,
Mulero F, Villanueva-Peñacarrillo ML, Vallet-Regí M, Esbrit P. J Biomed Mater Res A.
2016 Aug;104(8):2060-70.
- Analysis of Murine Lung Tumors by Micro PET-CT Imaging. Chiara Ambrogio, Juan
Antonio Cámara, Patricia Nieto, David Santamaría and Francisca Mulero. Bio-Protocol.
2015, 5(24)
- Monitoring vascular normalization induced by antiangiogenic treatment with 18Ffluoromisonidazole-PET. Hernández-Agudo E, Mondejar T, Soto-Montenegro ML, Megías
D, Mouron S, Sanchez J, Hidalgo M, Lopez-Casas PP, Mulero F, Desco M, QuintelaFandino M. Mol Oncol. 2015 Dec 22. pii: S1574-7891(15)00247-1. doi:
10.1016/j.molonc.2015.12.011. [Epub ahead of print]
- Adverse Effects of Diabetes Mellitus on the Skeleton of Aging Mice. Portal-Núñez S,
Ardura JA, Lozano D, Bolívar OH, López-Herradón A, Gutiérrez-Rojas I, Proctor A, van
der Eerden B, Schreuders-Koedam M, van Leeuwen J, Alcaraz MJ, Mulero F, de la Fuente
M, Esbrit P. JGerontol A Biol Sci Med Sci. 2015 Sep 18. pii: glv160.
- MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3. Cioffi M, Vallespinos-Serrano
M, Trabulo SM, Fernandez-Marcos PJ, Firment AN, Vazquez BN, Vieira CR, Mulero F,
Camara JA, Cronin UP, Perez M, Soriano J, G Galvez B, Castells-Garcia A, Haage V, Raj
D, Megias D, Hahn S, Serrano L, Moon A, Aicher A, Heeschen C. Cell Rep. 2015 Aug 26.
pii: S2211-1247(15)00862-1. doi: 10.1016/j.celrep.2015.08.006.
- Evaluation of the foetal time to death in mice after application of direct and indirect
euthanasia methods. Muñoz-Mediavilla C, Cámara JA, Salazar S, Segui B, Sanguino D,
Mulero F, de la Cueva E, Blanco I. Lab Anim. 2015 Aug 11. pii: 0023677215600626. [Epub
ahead of print]
- Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction. Povedano JM, Martinez
P, Flores JM, Mulero F, Blasco MA. Cell Rep. 2015 Jul 1. pii: S2211-1247(15)00640-3.
doi: 10.1016/j.celrep.2015.06.028. [Epub ahead of print]
- Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced
lung cancer by induction of telomeric DNA damage. García-Beccaria M, Martínez P,
Méndez-Pertuz M, Martínez S, Blanco-Aparicio C, Cañamero M, Mulero F, Ambrogio C,
Flores JM, Megias D, Barbacid M, Pastor J, Blasco MA. EMBO Mol Med. 2015 May 13
COVER
biomarcadores
CV
- Telomerase expression confers cardioprotection in the adult mouse heart after acute
myocardial infarction. Bär C, de Jesus BB, Serrano R, Tejera A, Ayuso E, Jimenez V,
Formentini I, Bobadilla M, Mizrahi J, de Martino A, Gomez G, Pisano D, Mulero F, Wollert
KC, Bosch F, Blasco MA. Nat Commun. 2014 Dec 18;5:5863.
- K-RasV14I recapitulates Noonan syndrome in mice. Hernández-Porras I, Fabbiano S,
Schuhmacher AJ, Aicher A, Cañamero M, Cámara JA, Cussó L, Desco M, Heeschen C,
Mulero F, Bustelo XR, Guerra C, Barbacid M. Proc Natl Acad Sci U S A. 2014 Oct 30. 111:
16395-16400.
- Modeling Lung Cancer Evolution and Pre-Clinical Response By Orthotopic Mouse
Allografts.
Ambrogio C, Carmona FJ, Vidal A, Falcone M, Nieto P, Romero OA, Puertas S, Vizoso M,
Nadal E, Poggio T, Sanchez-Cespedes M, Esteller M, Mulero F, Voena C, Chiarle R,
Barbacid M, Santamaria D, Villanueva A. Cancer Res. (2014) Sep 12. 1;74(21):5978-88
- Imagen molecular PET-TC en investigación preclínica oncológica. Cámara JA, Andrés E,
Sánchez S, Mulero F. RADIOPROTECCIÓN. (2014);79:44-49
- Parathyroid hormone-related protein (107-111) improves the bone regeneration potential
of gelatin-glutaraldehyde biopolymer-coated hydroxyapatite. Lozano D, Sánchez-Salcedo
S, Portal-Núñez S, Vila M, López-Herradón A, Ardura JA, Mulero F, Gómez-Barrena E,
Vallet-Regí M, Esbrit P. Acta Biomater. (2014) Jul;10(7):3307-16. doi:
10.1016/j.actbio.2014.03.025. Epub 2014 Apr 2.
- Bone environment is essential for osteosarcoma development from transformed
mesenchymal stem cells. Rubio R, Abarrategi A, Garcia-Castro J, Martinez-Cruzado L,
Suarez C, Tornin J, Santos L, Astudillo A, Colmenero I, Mulero F, Rosu-Myles M,
Menendez P, Rodriguez R. Stem Cells. (2014) Jan 20. doi: 10.1002/stem.1647. COVER
- In Vivo Ectopic Implantation Model to Assess Human Mesenchymal Progenitor Cell
Potential. Abarrategi A, Perez-Tavarez R, Rodriguez-Milla MA, Cubillo I, Mulero F,
Alfranca A, Lopez-Lacomba JL, García-Castro J. (2013) Stem Cell Rev and Rep 2013
Dec;9(6):833-46
- Therapeutic Effect of γ-Secretase Inhibition in Kras(G12V)-Driven Non-Small Cell Lung
Carcinoma by Derepression of DUSP1 and Inhibition of ERK. Maraver A, FernandezMarcos PJ, Herranz D, Cañamero M, Muñoz-Martin M, Gómez-López G, Mulero F,
Megías D, Sanchez-Carbayo M, Shen J, Sanchez-Cespedes M, Palomero T, Ferrando A,
Serrano M. (2012). Cancer Cell. 22(2):222-34.
biomarcadores
CV
- Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus
mTOR. Martínez González S, Hernández AI, Varela C, Lorenzo M, Ramos-Lima F,
Cendón E, Cebrián D, Aguirre E, Gomez-Casero E, Albarrán MI, Alfonso P, GarcíaSerelde B, Mateos G, Oyarzabal J, Rabal O, Mulero F, Gonzalez-Granda T, Link W,
Fominaya J, Barbacid M, Bischoff JR, Pizcueta P, Blanco-Aparicio C, Pastor J. (2012).
Bioorg Med Chem Lett. 22(16):5208-14
- Identification of ETP-46321, a potent and orallybioavailablePI3K a, d inhibitor. Martínez
González S, Hernández AI, Varela C, Rodríguez-Arístegui S, Lorenzo M, Rodríguez A,
Rivero V, Martín JI, Saluste CG, Ramos-Lima F, Cendón E, Cebrián D, Aguirre E, GomezCasero E, Albarrán M, Alfonso P, García-Serelde B, Oyarzabal J, Rabal O, Mulero F,
Gonzalez-Granda T, Link,W, Fominaya J, Barbacid M, Bischoff JR, Pizcueta P, Pastor J
(2012). Bioorg Med Chem Lett. 22(10):3460-6.
- Biological Properties of Solid Free Form Designed Ceramic Scaffolds with BMP-2: In
Vitro and In Vivo Evaluation. Abarrategi A , Moreno-Vicente C , Martínez-Vázquez FJ ,
Civantos A , Ramos V , Martínez-Corriá R, Perera F, Mulero F, Miranda FH, LópezLacomba JL. (2012). PLoS ONE 7(3): e34117. doi:10.1371/journal.pone.0034117
- Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity.
Ortega-Molina A, Efeyan A, Lopez-Guadamillas E, Muñoz-Martin M, Gómez-Ló pez G,
Cañamero M, Mulero F, Pastor J, Sonia Martínez S, Romanos E, Gonzalez-Barroso M M.,
Rial E, Valverde AM, Bischoff JR, Serrano M (2012). Cell Metab 15, 382-394
- Characterization of skeletal alterations in a model of prematurely aging mice. PortalNúñez S, Manassra R, Lozano D, Acitores A, Mulero F, Villanueva-Peñacarrillo ML, De la
Fuente M, Esbrit P. Age (2013) 35: 383-389.
- Evc works in chondrocytes and osteoblasts to regulate multiple aspects of growth plate
development in the appendicular skeleton and cranial base. Pacheco M, Valencia M,
Caparrós-Martín JA, Mulero F, Goodship JA, Ruiz-Perez VL. Bone 2012 Jan;50(1):28-41.
- Imaging Cancer in Mice by PET, CT, and Combined PET-CT Mulero F, Donate LE,
Serrano M. (2011). Curr. Protoc. Mouse Biol. 1:85-103
- Constitutive activation of B-Raf in the mouse germ line provides a model for human
cardio-facio-cutaneous syndrome Urosevic J, Sauzeau V, Soto-Montenegro ML, Reig S,
Desco M, Burkitt EM, Cañamero M, Mulero F, Ortega S, Bustelo XR, Barbacid M. PNAS.
2011;108(12):5015–5020
biomarcadores
CV
- Combination of Injectable Multiple Growth Factor–Releasing Scaffolds and Cell Therapy
as an Advanced Modality to Enhance Tissue Neovascularization. Jaimy Saif, Theresa M.
Schwarz, David Y.S. Chau, James Henstock, Paramjit Sami, Simon F. Leicht, Patrick C.
Hermann, Sonia Alcala, Francisca Mulero, Kevin M. Shakesheff, Christopher Heeschen,
Alexandra Aicher. Arterioscler Thromb Vasc Biol. 2010;30:1897-1904 (Oct. DOI:
10.1161/ATVBAHA.110.207928)
- A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic
strategic for non small cell lung carcinoma. Puyol M, Martín A, Dubus P, Mulero F,
Pizcueta P, Khan G, Guerra C, Santamaría D, Barbacid M. Cancer Cell. 2010 Jul.
13;18(1):63-73.
- Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer
sindrome. Herranz D, Muñoz-Martín M, Cañamero M, Mulero F, Martínez-Pastor B,
Fernández-Capetillo O, Serrano M. 2010. April. Nature Nat. Commun. 1:3
doi:10.1038/ncomms1001.
- ATR suppresses telomere fragility and recombination but is dispensable for elongation of
short telomeres by telomerase McNees CJ, Tejera AM, Martínez P, Murga M, Mulero F,
Fernandez-Capetillo O, Blasco MA. J Cell Biol. 2010 Mar 8;188(5):639-52.
- Imagen Molecular en Investigación Biomédica. Unidad de Imagen Molecular del Centro
Nacional de Investigaciones Oncológicas. Perez J, Mulero F. Radioprotección 2010 62;17:
26-35.
- Targeted activation of innate immunity for therapeutic induction of autophagy and
apoptosis in melanoma cells. Tormo D, Checińska A, Alonso-Curbelo D, Pérez-Guijarro E,
Cañón E, Riveiro-Falkenbach E, Calvo TG, Larribere L, Megías D, Mulero F, Piris MA,
Dash R, Barral PM, Rodríguez-Peralto JL, Ortiz-Romero P, Tüting T, Fisher PB, Soengas
MS. Cancer Cell. 2009 Aug 4;16(2):103-14.
- A mouse model of the ATR-Seckel Syndrome reveals that replicative stress during
embryogenesis limits mammalian lifespan. Murga M, Bunting S, Montaña MF, Soria R,
Mulero F, Cañamero M, Lee Y, McKinnon PJ, Nussenzweig A, Fernandez-Capetillo O. Nat
Genet 2009 Aug;41(8):891-8
- Doppler ultrasonographic and scintigraphic assessment of an auxiliary heterotopic liver
transplantation with portal vein arterialization in pigs. Fernandez-Rodriguez OM, Rios A,
Navarro JL, Pons JA, Berenguer JJ, Mulero F, et al. Transplant Proc. 2006 Apr;38(3):963966.

Francisca Mulero

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