SANDRA ROMERO HIDALGO Guadalupe I. Ramírez 1008 Casa 9
Transcripción
SANDRA ROMERO HIDALGO Guadalupe I. Ramírez 1008 Casa 9
SANDRA ROMERO HIDALGO Guadalupe I. Ramírez 1008 Casa 9 Colonia Santa María Tepepan México D.F., 16020 Cel.: (52)5518441769 R.F.C. ROHS700703 IG9 Email: [email protected] LÍNEA INVESTIGACIÓN Diseño y análisis de estudios de variabilidad genética y genómica para diferentes fenotipos, tanto Mendelianos como complejos, con enfasis en estudios de ligamiento, estudios de asociación, estudios de genética de poblaciones y estudios en donde se evalua interacción gen-gen y gen-ambiente. FORMACIÓN ACADÉMICA Doctora en Ciencias, Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México (UNAM), México, 2001 - 2005 Maestría en Matemáticas en Bioestadística, Universidad de Waterloo, Canadá, 1999 2000 Licenciatura en Actuaría, Universidad Nacional Autónoma de México (UNAM), México, 1991 -1994 PLAZA LABORAL ACTUAL Investigador en Ciencias Médicas “D”, Departamento de Genómica Computacional, Instituto Nacional de Medicina Genómica, 2011 a la fecha DOCENCIA Profesor de Tiempo Parcial, 2001 a la fecha Instituto Nacional de Medicina Genómica, 2010 a la fecha Instituto de Servicios Social y Sevicios de los trabajadores del Estado (ISSSTE), 2005-2014 Licenciatura en Ciencias Genómicas, 2012 - 2015 Facultad de Ciencias, UNAM, 2010 Instituto Tecnológico Autónomo de México (ITAM), 2001 - 2005 DISTINCIONES Sistema Nacional de Investigadores (SNI), Nivel I, 2011 a 2016 Sistema Nacional de Investigadores (SNI), Candidato, 2008 a 2010 Premio Nacional de Investigación ISSSTE 2011, Primer lugar Beca CONACyT para realizar estudios de doctorado en territorio nacional, 2001-2005. Beca CONACyT para realizar estudios de maestría en el extranjero, 1999-2000. PUBLICACIONES 1. Ruiz-Contreras AE, Román-López TV, Caballero-Sánchez U, Rosas-Escobar CB, Ortega-Mora EI, Barrera-Tlapa MA, Romero-Hidalgo S, Carrillo-Sánchez K, Hernández-Morales S, Vadillo-Ortega F, González-Barrios JA, Méndez-Díaz M, Prospéro-García O. Because difficulty is not the same for everyone: the impact of complexity in working memory is associated with cannabinoid 1 receptor genetic variation in young adults. Memory. 2016 Apr 25:1-9. 2. Jacobo-Albavera L, Posadas-Romero C, Vargas-Alarcón G, Romero-Hidalgo S, Posadas-Sánchez R, González-Salazar Mdel C, Carnevale A, Canizales-Quinteros S, Medina-Urrutia A, Antúnez-Argüelles E, Villarreal-Molina T. Dietary fat and carbohydrate modulate the effect of the ATP-binding cassette A1 (ABCA1) R230C variant on metabolic risk parameters in premenopausal women from the Genetics of Atherosclerotic Disease (GEA) Study. Nutr Metab. 2015 Nov 16;12:45. 3. Palacios-González B, Vadillo-Ortega F, Polo-Oteyza E, Sánchez T, Ancira-Moreno M, Romero-Hidalgo S, Meráz N, Antuna-Puente B. Irisin levels before and after physical activity among school-age children with different BMI: a direct relation with leptin. Obesity 2015 Apr;23(4):729-32. 4. Ordoñez G, Romero S, Orozco L, Pineda B, Jiménez-Morales S, Nieto A, GarcíaOrtiz H, Sotelo J. Genomewide admixture study in Mexican Mestizos with multiple sclerosis. Clin Neurol Neurosurg. 2015 Mar;130:55-60. 5. Majithia AR, Flannick J, Shahinian P, Guo M, Bray MA, Fontanillas P, Gabriel SB; GoT2D Consortium; NHGRI JHS/FHS Allelic Spectrum Project; SIGMA T2D Consortium; T2D-GENES Consortium, Rosen ED, Altshuler D. Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13127-32. 6. Moreno-Estrada A, Gignoux CR, Fernández-López JC, Zakharia F, Sikora M, Contreras AV, Acuña-Alonzo V, Sandoval K, Eng C, Romero-Hidalgo S, Ortiz-Tello P, Robles V, Kenny EE, Nuño-Arana I, Barquera-Lozano R, Macín-Pérez G, Granados-Arriola J, Huntsman S, Galanter JM, Via M, Ford JG, Chapela R, Rodriguez-Cintron W, Rodríguez-Santana JR, Romieu I, Sienra-Monge JJ, del Rio Navarro B, London SJ, Ruiz-Linares A, Garcia-Herrera R, Estrada K, HidalgoMiranda A, Jimenez-Sanchez G, Carnevale A, Soberón X, Canizales-Quinteros S, Rangel-Villalobos H, Silva-Zolezzi I, Burchard EG, Bustamante CD. Human genetics. The genetics of Mexico recapitulates Native American substructure and affects biomedical traits. Science. 2014 Jun 13;344(6189):1280-5. 7. Larrieta-Carrasco E, Acuña-Alonzo V, Velázquez-Cruz R, Barquera-Lozano R, León-Mimila P, Villamil-Ramírez H, Menjivar M, Romero-Hidalgo S, MéndezSánchez N, Cárdenas V, Bañuelos-Moreno M, Flores YN, Quiterio M, Salmerón J, Sánchez-Muñoz F, Villarreal-Molina T, Aguilar-Salinas CA, Canizales-Quinteros S. PNPLA3 I148M polymorphism is associated with elevated alanine transaminase levels in Mexican Indigenous and Mestizo populations. Mol Biol Rep. 2014 Jul; 41(7):4705-11. 8. The SIGMA Type 2 Diabetes Consortium; Analysis team: Williams AL, MárquezLuna C, Huerta-Chagoya A, Ripke S, José Gómez-Vázquez M, Manning AK, Moreno-Macías H, García-Ortíz H, Neale B, Burtt NP, Aguilar-Salinas CA, Reich D, Stram DO, Fernández-López JC, Romero-Hidalgo S, Altshuler D, Florez JC, TusiéLuna T, Patterson N, Haiman CA. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. Nature. 2014 Feb; 506(7486):97-101. 9. García-Velázquez LE, Canizales-Quinteros S, Romero-Hidalgo S, Ochoa-Morales A, Martínez-Ruano L, Márquez-Luna C, Acuña-Alonzo V, Villarreal-Molina MT, Alonso-Vilatela ME, Yescas-Gómez P. Founder effect and ancestral origin of the spinocerebellar ataxia type 7 (SCA7) mutation in Mexican families. Neurogenetics. 2014 Mar; 15(1)13-7. 10. Ruiz-Contreras AE, Carrillo-Sánchez K, Ortega-Mora I, Barrera-Tlapa MA, RománLópez TV, Rosas-Escobar CB, Flores-Barrera L, Caballero-Sánchez U, MuñozTorres Z, Romero-Hidalgo S, Hernández-Morales S, González-Barrios JA, VadilloOrtega F, Méndez-Díaz M, Aguilar-Roblero R, Prospéro-García O. Performance in working memory and attentional control is associated with the rs2180619 SNP in the CNR1 gene. Genes Brain Behav. 2014 Feb; 13(2):173-8. 11. León-Mimila P, Villamil-Ramírez H, Villalobos-Comparán M, Villarreal-Molina T, Romero-Hidalgo S, López-Contreras B, Gutiérrez-Vidal R, Vega-Badillo J, JacoboAlbavera L, Posadas-Romeros C, Canizalez-Román A, Río-Navarro BD, CamposPérez F, Acuña-Alonzo V, Aguilar-Salinas C, Canizales-Quinteros S. Contribution of common genetic variants to obesity and obesity-related traits in mexican children and adults. PLoS One. 2013 Aug 8;8(8):e70640. 12. Larrieta-Carrasco E, León-Mimila P, Villarreal-Molina T, Villamil-Ramírez H, Romero-Hidalgo S, Jacobo-Albavera L, Gutiérrez-Vidal R, López-Contreras BE, Guillén-Pineda LE, Sánchez-Muñoz F, Bojalil R, Mejía-Domínguez AM, MéndezSánchez N, Domínguez-López A, Aguilar-Salinas CA, Canizales-Quinteros S. Association of the I148M/PNPLA3 variant with elevated alanine transaminase levels in normal-weight and overweight/obese Mexican children. Gene. 2013 May 15;520(2):185-8. 13. Jacobo-Albavera L, Aguayo-de la Rosa PI, Villarreal-Molina T, Villamil-Ramírez H, León-Mimila P, Romero-Hidalgo S, López-Contreras BE, Sánchez-Muñoz F, Bojalil R, González-Barrios JA, Aguilar-Salinas CA, Canizales-Quinteros S. VNN1 gene expression levels and the G-137T polymorphism are associated with HDL-C levels in Mexican prepubertal children. PLoS One. 2012;7(11):e49818. 14. Villarreal-Molina T, Posadas-Romero C, Romero-Hidalgo S, Antúnez-Argüelles E, Bautista-Grande A, Vargas-Alarcón G, Kimura-Hayama E, Canizales-Quinteros S, Juárez-Rojas JG, Posadas-Sánchez R, Cardoso-Saldaña G, Medina-Urrutia A, González-Salazar Mdel C, Martínez-Alvarado R, Jorge-Galarza E, Carnevale A. The ABCA1 gene R230C variant is associated with decreased risk of premature coronary artery disease: the genetics of atherosclerotic disease (GEA) study. PLoS One. 2012;7(11):e49285. 15. Villalobos-Comparán M, Villamil-Ramírez H, Villarreal-Molina T, Larrieta-Carrasco E, León-Mimila P, Romero-Hidalgo S, Jacobo-Albavera L, Liceaga-Fuentes AE, Campos-Pérez FJ, López-Contreras BE, Tusié-Luna T, Del Río-Navarro BE, Aguilar-Salinas CA, Canizales-Quinteros S. PCSK1 rs6232 Is Associated with Childhood and Adult Class III Obesity in the Mexican Population. PLoS One. 2012;7(6):e39037. 16. Romero-Hidalgo S, Villarreal-Molina T, González-Barrios JA, Canizales-Quinteros S, Rodríguez-Arellano ME, Yañez-Velazco LB, Bernal-Alcantara DA, Villa AR, Antuna-Puente B, Acuña-Alonzo V, Merino-García JL, Moreno-Sandoval HN, Carnevale A. Carbohydrate intake modulates the effect of the ABCA1-R230C variant on HDL cholesterol concentrations in premenopausal women. J Nutr. 2012 Feb;142(2):278-83. 17. Rojano-Mejía D, Coral-Vázquez RM, Espinosa LC, Romero-Hidalgo S, LópezMedina G, García Mdel C, Coronel A, Ibarra R, Canto P. TNFRSF11B gene haplotype and its association with bone mineral density variations in postmenopausal Mexican-Mestizo women. Maturitas. 2012 Jan;71(1):49-54. 18. Flores-Dorantes T, Arellano-Campos O, Posadas-Sánchez R, Villarreal-Molina T, Medina-Urrutia A, Romero-Hidalgo S, Yescas-Gómez P, Pérez-Méndez O, JorgeGalarza E, Tusié-Luna T, Villalobos-Comparán M, Jacobo-Albavera L, VillamilRamírez H, López-Contreras BE, Aguilar-Salinas CA, Posadas-Romero C, Canizales-Quinteros S. (2010) Association of R230C ABCA1 gene variant with low HDL-C levels and abnormal HDL subclass distribution in Mexican school-aged children. Clin Chim Acta 411(17-18):1214-7. 19. Acuña-Alonzo V, Flores-Dorantes T, Kruit JK, Villarreal-Molina T, Arellano-Campos O, Hünemeier T, Moreno-Estrada A, Ortiz-López MG, Villamil-Ramírez H, LeónMimila P, Villalobos-Comparan M, Jacobo-Albavera L, Ramírez-Jiménez S, Sikora M, Zhang LH, Pape TD, Granados-Silvestre Mde A, Montufar-Robles I, Tito-Alvarez AM, Zurita-Salinas C, Bustos-Arriaga J, Cedillo-Barrón L, Gómez-Trejo C, Barquera-Lozano R, Vieira-Filho JP, Granados J, Romero-Hidalgo S, HuertasVázquez A, González-Martín A, Gorostiza A, Bonatto SL, Rodríguez-Cruz M, Wang L, Tusié-Luna T, Aguilar-Salinas CA, Lisker R, Moises RS, Menjivar M, Salzano FM, Knowler WC, Bortolini MC, Hayden MR, Baier LJ, Canizales-Quinteros S. (2010) A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans. Hum Mol Genet 19(14):2877-85. 20. Romero-Hidalgo S, Urraca N, Parra D, Villa AR, Lisker R, Carnevale A. (2009) Attitudes and anticipated reactions to genetic testing for cancer among patients in Mexico City. Genet Test Mol Biomarkers 13(4):477-83. 21. Jiménez-Morales S, Velázquez-Cruz R, Ramírez-Bello J, Bonilla-González E, Romero-Hidalgo S, Escamilla-Guerrero G, Cuevas F, Espinosa-Rosales F, Martínez-Aguilar NE, Gómez-Vera J, Baca V, Orozco L. (2009) Tumor necrosis factor-alpha is a common genetic risk factor for asthma, juvenile rheumatoid arthritis, and systemic lupus erythematosus in a Mexican pediatric population. Hum Immunol. 70(4):251-6. 22. Villalobos-Comparan M, Flores-Dorantes MT, Villarreal-Molina MT, Rodríguez-Cruz M, García-Ulloa AC, Robles L, Huertas-Vazquez A, Saucedo-Villarreal N, LópezAlarcón M, Sánchez-Muñoz F, Domínguez-López A, Gutiérrez-Aguilar R, Menjivar M, Coral-Vázquez R, Hernández-Stengele G, Vital-Reyes VS, Acuña-Alonzo V, Romero-Hidalgo S, Ruiz-Gomez DG, Riaño-Barros D, Herrera MF, Gomez-Perez FJ, Froguel P, García-García E, Tusie-Luna MT, Aguilar-Salinas CA, CanizalesQuinteros S. (2008) The FTO gene is associated with adulthood obesity in the Mexican population. Obesity 16(10):2296-301. 23. Villarreal-Molina MT, Flores-Dorantes MT, Arellano-Campos O, VillalobosComparan M, Rodríguez-Cruz M, Miliar-García A, Huertas-Vazquez A, Menjivar M, Romero-Hidalgo S, Wacher NH, Tusie-Luna MT, Cruz M, Aguilar-Salinas CA, Canizales-Quinteros S; Metabolic Study Group. (2008) Association of the ATPbinding cassette transporter A1 R230C variant with early-onset type 2 diabetes in a Mexican population. Diabetes 57(2):509-13. 24. Villarreal-Molina MT, Aguilar-Salinas CA, Rodríguez-Cruz M, Riaño D, VillalobosComparan M, Coral-Vázquez R, Menjivar M, Yescas-Gómez P, Könisberg-Fainstein M, Romero-Hidalgo S, Tusié-Luna MT, Canizales-Quinteros S and the Metabolic Study Group. (2007) The ATP-Binding Cassette Transporter A1 R230C Variant Affects HDL-cholesterol Levels and BMI in the Mexican Population: Association with Obesity and Obesity-Related Comorbidities. Diabetes 56(7):1881-1887. 25. Canizales-Quinteros S, Huertas-Vázquez A, Riba-Ramírez L, Monroy-Guzmán A, Domínguez-López A, Romero-Hidalgo S, Aguilar-Salinas C, Rodríguez-Torres M, Ramírez-Jiménez S, Tusié-Luna MT. (2005) [Identifying different susceptibility loci associated with early onset diabetes and cardiovascular disease in Mexican families]. Gac Med Mex 141:115-22. Español. 26. Romero-Hidalgo S, Gutierrez-Peña E, Rodrigues ER, Riba L, Tusié-Luna MT. (2005) GENEHUNTER versus SimWalk2 in the context of an extended kindred and a qualitative trait locus. Genetica 123:235-244. 27. Chen J, Kalbfleisch JD, Romero-Hidalgo S. (2002) Statistical analysis of genetic data of affected sib pairs. The Canadian Journal of Statistics 30(1):145-152. 28. Brejova B, DiMarco C, Vinar T, Romero-Hidalgo S, Holguin G, Patten C. (2000) Finding Patterns in Biological Sequences. Technical Report CS-2000-22, University of Waterloo.