doc38 effects of hyal joint on clinical and some synovial fluid
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38 effects of hyal joint on clinical and some synovial fluid
EFFECTS OF HYAL-JOINT® ON CLINICAL AND SOME SYNOVIAL FLUID BIOCHEMICAL PARAMETERS OF YOUNG HORSES WITH OSTEOCHONDROSIS1 Jorge U. Carmona1, David Argüelles2, Marta Prades3 Objective: The aim was to evaluate the clinical and biochemical effects of oral hyaluronic acid (HA) (Hyal-Joint®) in young horses with osteochondrosis (OC). Our hypotheses were that the administration of oral HA is safe, diminishes the degree of synovial effusion and the synovial concentrations of nitric oxide (NO) and prostaglandin E2 (PGE2) and increases the plasma and synovial concentrations of HA. Material and Methods: Eleven young horses with tarsocrural OC were included in a pilot randomized double blinded controlled study. Six horses received oral HA at 250 mg/day, for 60 days (T60) with 5 horses receiving a placebo. The initial values from the degree of synovial effusion, NO, PGE2 and HA synovial fluid concentrations and the concentration of HA in plasma were determined. The same variables were determined in each of the horses at the end of treatment (T60) and again 30 days later (T90). Results: Statistically significant differences for each of the variables evaluated between either group was not noted at T0, T60 or T90. Nevertheless, the horses treated with oral HA showed a tendency to word a lesser degree of synovial effusion and a trend for greater synovial HA concentrations. Oral HA at a dose of 250 mg/day did not produce any clinical side effect and was well tolerated by the horses. 1 This research was supported by Bio-Ibérica SA, Palfolls, Spain. Grupo de Investigación Terapia Regenerativa, Departamento de Salud Animal, Universidad de Caldas, Calle 65 No 26-10, Manizales, Caldas, Colombia. E-mail: [email protected] 1 2 La Equina, Equine Hospital. Apartado 110 Sabinillas. 29692, Manilva, Málaga, Spain. 3 Departamento de Medicina y Cirugía Animal, Universidad Autónoma de Barcelona, Edificio V. 08193. Bellaterra, Barcelona, Spain.
