Manuela G. Lopez, MD, PhD

Manuela G. López Manuela G. Lopez, MD, PhD Professor of Pharmacology Sub‐Director of Instituto Teófilo Hernando for Drug Discovery Universidad Autónoma de Madrid, Madrid, Spain 
RESEARCH INTEREST 1. Neuropharmacology‐ mechanism of action of neuroprotective drugs 2. Alzheimer´s disease and stroke models to evaluate new potentially therapeutic drugs. 3. Neuroinflammation and oxidative stress in the control of neurodegeneration and brain ischemia. 4. Regulation of the transcription factor Nrf2: impact in neuronal diseases and as target for drug development of neuroprotective drugs. 5. Impact of α7 nicotinic acetylcholine receptors and melatonin receptors in neuroinflammation and neuroprotection. ORCID ID. orcid.org/0000‐0003‐4461‐8788 Research gate: https://www.researchgate.net/profile/Manuela_Lopez 
RECENT PUBLICATIONS 2010 N. CAÑAS, R. GORINA, A M PLANAS, J. VERGÉS, E. MONTELL, A.G. GARCÍA, M. G LÓPEZ Chondroitin sulfate inhibits lipopolysaccharide‐induced inflammation in rat astrocytes by preventing NFкB activation. Neuroscience 167: 872‐879. 2010 A. ROMERO, J. EGEA, A.G. GARCÍA, M.G. LÓPEZ. Synergistic neuroprotective effect of combined concentrations of galantamine and melatonin against oxidative stress in SH‐SY5Y neuroblastoma cells. J. Pineal Res. 49:141‐148. 2010 1 Manuela G. López J. EGEA, A.G. GARCÍA, J. VERGES, E. MONTELL, M. G. LÓPEZ. Antioxidant, antiinflammatory and neuroprotective actions of chondroitin sulfate and proteoglycans: A narrative review. Osteoarthritis and cartilage 1:S24‐27. 2010 R. C. SOLETTI, L. DEL BARRIO, S. DAFFRE, A. MIRANDA, H.L.B. VIVALDO MOURA‐NETO, M. G. LOPEZ , N.H. GABILAN. Gomesin‐induced cell death of human neuroblastoma cells is mediated by calcium influx through L‐type calcium channels, reactive oxygen species generation and MAPK, PKC and PI3K signalling. Chemico‐Biological Interactions 186: 135–143. 2010 M.I. FERNÁNDEZ‐BACHILLER, C. PÉREZ, G.C. GONZÁLEZ‐MUÑOZ, S CONDE, M.G. LÓPEZ, M. VILLARROYA, A.G. GARCÍA, M.I. RODRÍGUEZ‐FRANCO. Novel Tacrine‐8‐
Hydroxyquinoline Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Neuroprotective, Cholinergic, Antioxidant, and Copper‐Complexing Properties J. Med. Chem, 53(13):4927‐37. 2010 C.L DE LOS RÍOS, J. EGEA, J.L MARCO‐CONTELLES, R.L LEÓN, A. SAMADI, I. IRIEPA, I. MORALEDA, E. GÁLVEZ, A.G. GARCÍA, M. G.LÓPEZ, M. VILLARROYA, A. ROMERO Synthesis, Inhibitory Activity of Cholinesterases and Neuroprotective Profile of Novel 1,8‐Naphthyridine Derivatives. J. Med. Chem, (53(14):5129‐5143. 2010 A. SAMADI; J L. MARCO; E. SORIANO; M. ÁLVAREZ‐PÉREZ; M. CHIOUA; A. ROMERO; L. GONZÁLEZ‐LAFUENTE; L. GANDÍA; JOSÉ M. RODA; M.G. LÓPEZ; M. VILLARROYA; A.G. GARCÍA; C. DE LOS RÍOS. Multipotent Drugs with Cholinergic and Neuroprotective Properties for the Treatment of Alzheimer and Neuronal Vascular Diseases: Synthesis, Biological Assessment, and Molecular Modelling of Simple and Readily Available 2‐Aminopyridine‐, and 2‐Chloropyridine‐3,5‐
dicarbonitriles. Bioorganic & Medicinal Chemistry, 18:5861‐5872. 2010 S.M. NICOLAU, J. EGEA, M.G. LÓPEZ, A.G. GARCÍA. Mitochondrial Na(+)/Ca(2+) exchanger, a new target for neuroprotection in rat hippocampal slices. Biochem Biophys Res Commun. 400:140‐144. 2010 E. PARADA, J. EGEA, A. ROMERO, L. DEL BARRIO, A.G. GARCÍA AND M. G. LÓPEZ. Post‐stress treatment with PNU282987 can rescue SH‐SY5Y cells undergoing apoptosis via α7 nicotinic receptors linked to a Jak2/Akt/HO‐1 signaling pathway. Free Radical Biology and Medicine. 49:1815‐1821. 2010 G.C. GONZÁLEZ‐MUÑOZ, M.P. ARCE, B. LÓPEZ, C. PÉREZ, M. VILLARROYA, M.G. LÓPEZ, A.G. GARCÍA, S. CONDE, M.I. RODRÍGUEZ‐FRANCO. Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow’s neuroprotective therapies against neurodegenerative diseases. European Journal of Medicinal Chemistry. 45:6152‐6158. 2010 2 Manuela G. López 2011 L. DEL BARRIO, J. EGEA, R. LEÓN, A. ROMERO, A. RUIZ, M. MONTERO, J. ÁLVAREZ AND M.G. LÓPEZ. Calcium signaling mediated through α7 and non‐α7 nAChR stimulation is differentially regulated in bovine chromaffin cells to induce catecholamine release. Br. J Pharmacol. 162: 94‐110. 2011 MARTINS DF, ROSA AO, GADOTTI VM, MAZZARDO‐MARTINS L, NASCIMENTO FP, EGEA J, LÓPEZ MG, SANTOS AR.The Antinociceptive Effects of AR‐A014418, a Selective Inhibitor of Glycogen Synthase Kinase‐3 Beta, in Mice. J Pain. 12:315‐322. 2011 SAMADI A, VALDERAS C, DE LOS RÍOS C, BASTIDA A, CHIOUA M, GONZÁLEZ‐LAFUENTE L, COLMENA I, GANDÍA L, ROMERO A, DEL BARRIO L, MARTÍN‐DE‐SAAVEDRA MD, LÓPEZ MG, VILLARROYA M, MARCO‐CONTELLES J. Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2‐aminopyridine‐3‐carbonitriles. Bioorg Med Chem. 19:122‐33. 2011 MARTIN‐DE‐SAAVEDRA MD, DEL BARRIO L, CAÑAS N, EGEA J, LORRIO S, MONTELL E, VERGES J, GARCIA AG, LOPEZ MG. Chondroitin sulfate reduces cell death of rat hippocampal slices subjected to oxygen and glucose deprivation by inhibiting p38, NFκB and iNOS. Neurochemistry International 58(6):676‐683. 2011 G C. GONZÁLEZ‐MUÑOZ, M P. ARCE, B LÓPEZ, C PÉREZ, A ROMERO, L DEL BARRIO,M D MARTÍN‐DE‐SAAVEDRA,M VILLARROYA, M G. LÓPEZ, A G. GARCÍA,S CONDE, M I RODRÍGUEZ‐FRANCO. N‐Acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer’s disease. Eur. J. Med. Chem 46:2224‐2235.2011 S. MOLZ, T. DAL‐CIM, J. BUDNI, M.D. MARTÍN‐DE‐SAAVEDRA, J. EGEA, A. ROMERO, L. DEL BARRIO, A.L.S. RODRIGUES, M.G. LÓPEZ, C.I. TASCA. The neuroprotective effect of guanosine against glutamate‐induced cell death in rat hippocampal slices is mediated by PI3K/Akt/GSK3 pathway activation and iNOS inhibition. J. Neurosci. Res. 58: 676–683. 2011 BUDNI J, ROMERO A, MOLZ S, MARTÍN‐DE‐SAAVEDRA MD, EGEA J, DEL BARRIO L, TASCA CI, RODRIGUES AL, AND LOPÉZ MG. Neurotoxicity induced by 3 Manuela G. López dexamethasone in the human neuroblastoma SH‐SY5Y cell line can be prevented by folic acid. Neuroscience 190:346‐53. 2011 D. SILVA, M. CHIOUA, A. SAMADI, M. CARMO CARREIRAS, M L JIMENO, C. DE LOS RÍOS, A. ROMERO, MERCEDES VILLARROYA, M.G. LÓPEZ, J.L. MARCO‐
CONTELLES. Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4‐
b]quinoline, and benzo[b]pyrazolo[4,3‐g][1,8]naphthyridine derivatives . Eur. J. Med. Chem. 46: 4676‐4681. 2011 DEL BARRIO L, MARTIN‐DE‐SAAVEDRA MD, ROMERO A, PARADA E, EGEA J, MCINTOSH JM, WONNACOTT S AND LOPEZ MG. Neurotoxicity induced by okadaic acid in the human neuroblastoma SH‐SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation. Tox. Sciences. 123(1):193‐205. 2011. BARTOLINI M, PISTOLOZZI M, ANDRISANO V, EGEA J, LÓPEZ MG, IRIEPA I, MORALEDA I, GALVEZ E, MARCO‐CONTELLES JL, SAMADI A. Chemical and Pharmacological Studies on Enantiomerically Pure p‐Methoxytacripyrines, Promising Multi‐Target‐
Directed Ligands for the Treatment of Alzheimer’s Disease ChemMedChem 6:1990‐1997. 2011. CARLA MARTINS, M. CARMO CARREIRAS, RAFAEL LEÓN, CRISTÓBAL DE LOS RÍOS, MANUELA BARTOLINI, VINCENZA ANDRISANO, ISABEL IRIEPA, IGNACIO MORALEDA, ENRIQUE GÁLVEZ, MANUELA GARCÍA, JAVIER EGEA, ABDELOUHAID SAMADI, MOURAD CHIOUA, JOSÉ MARCO‐CONTELLES. Synthesis and biological assessment of diversely substituted furo[2,3‐b]quinolin‐4‐amine and pyrrolo[2,3‐b]quinolin‐4‐
amine derivatives, as novel tacrine analogues. Eur. J. Med Chem. 46: 6119‐6130. 2011 2012 EGEA J, MARTÍN‐DE‐SAAVEDRA MD, PARADA E, ROMERO A, DEL BARRIO L, ROSA AO, GARCÍA AG, LÓPEZ MG. Galantamine elicits neuroprotection by inhibiting iNOS, NADPH oxidase and ROS in hippocampal slices stressed with anoxia/reoxygenation. Neuropharmacology 62:1082‐1090. 2012 EGEA J, MALMIERCA E, ROSA AO, DEL BARRIO L, NEGREDO P, NUÑEZ A, LÓPEZ MG 4 Manuela G. López Participation of calbindin‐D28K in nociception: results from calbindin‐D(28K) knockout mice. Eur. J. Physiol. Pflugers Arch. 463(3):449‐458. 2012 BUDINI J, LOBATO KR, BINFARÉ RW, FREITAS AE, COSATA AP, MARTÍN DE SAAVEDRA MD, LEAL RB, LÓPEZ MG, SEVERO RODRIGUES AN. Involvement of PI3K, GSK‐3β and PPARγ in the antidepressant‐like effect of folic acid in the forced swimming test in mice. J. Phycopharmacol. 26:714‐723. 2012 LAURA GONZALEZ‐LAFUENTE, JAVIER EGEA, RAFAEL LEON, FRANCISCO J. MARTINEZ‐
SANZ, CRISTINA MERINO, ANTONIO M. GARCIA‐DE DIEGO, ANTONIO G. GARCIA, MERCEDES VILLARROYA, MANUELA G. LOPEZ, CRISTOBAL DE LOS RIOS Benzothiazepine CGP37157 and its isosteric 2’‐methyl analogue provide neuroprotection and block cell calcium entry. ACS Chemical Neuroscience 3(7):519‐529. 2012 T DAL‐CIM, S MOLZ, J EGEA, E PARADA, A ROMERO, J BUDNI, MD. MARTÍN‐DE‐
SAAVEDRA, L DEL BARRIO, CI TASCA AND MG. LÓPEZ. Guanosine protects human neuroblastoma SH‐SY5Y cells against mitochondrial oxidative stress by inducing Hemoxigenase‐1 via PI3K/Akt/GSK‐3β. Neurochem. Int. 61(3):397‐404. 2012 2013 S. LORRIO, V GÓMEZ‐RANGEL, P NEGREDO, J. EGEA, R LEON, A ROMERO, T DAL‐CIM, M VILLARROYA, MI RODRIGUEZ‐FRANCO, S CONDE, MP ARCE, JM RODA, AG GARCÍA & MG LÓPEZ. Novel multitarget ligand ITH33/IQM9.21 provides neuroprotection in in vitro and in vivo models related to brain ischemia. Neuropharmacology 67: 403–411. 2013 PARADA E, EGEA J, BUENDIA I, NEGREDO P, CUNHA AC, CARDOSO S, SOARES MP AND LOPEZ MG. The microglialα7 acetylcholine nicotinic receptor is a key element in promoting neuroprotection by inducing HO‐1 via Nrf2. Antioxidants & Redox Signaling. 19(11):1135‐48. 2013 JACQUES AV, RIEGER DK, MAESTRI M, LOPES MW, PERES TV, GONÇALVES FM, PEDRO DZ, TASCA CI, LÓPEZ MG, EGEA J, NASCIMENTO KS, CAVADA BS, LEAL RB. 5 Manuela G. López Lectin from Canavalia brasiliensis (ConBr) protects hippocampal slices against glutamate neurotoxicity in a manner dependent of PI3K/Akt pathway. Neurochem Int. 62:836‐842. 2013. ROMERO A, GOMEZ‐RANGEL V, EGEA J, SAMADI A, MARCO‐CONTELLES J, LOPEZ MG. Enantioselective Neuroprotective Effects of Tacripyrine ITH122 Against Oxygen and Glucose Deprivation in Rat Hippocampal Slices. CNS Neurosci Ther. 19:285‐287. 2013 BARROS‐MIÑONES L, MARTÍN‐DE‐SAAVEDRA D, PEREZ‐ALVAREZ S, OREJANA L, SUQUÍA V, GOÑI‐ALLO B, HERVIAS I, LÓPEZ MG, JORDAN J, AGUIRRE N, PUERTA E. Inhibition of calpain‐regulated p35/cdk5 plays a central role in sildenafil‐induced protection against chemical hypoxia produced by malonate. Biochim Biophys Acta. doi:pii: S0925‐4439(13)00039‐2. 10.1016/j.bbadis.2013.02.002. CUNHA MP, MARTÍN‐DE‐SAAVEDRA MD, ROMERO A, PARADA E, EGEA J, DEL BARRIO L, RODRIGUES AL, LÓPEZ MG. Protective effect of creatine against 6‐
hydroxydopamine‐induced cell death in human neuroblastoma SH‐SY5Y cells: Involvement of intracellular signaling pathways. Neuroscience. 238:185‐194. 2013. MARTÍN‐DE‐SAAVEDRA MD, BUDNI J, CUNHA MP, GÓMEZ‐RANGEL V, LORRIO S, DEL BARRIO L, LASTRES‐BECKER I, PARADA E, TORDERA RM, RODRIGUES ALS, CUADRADO A AND LÓPEZ MG.Nrf2 participates in depressive disorders through an anti‐inflammatory mechanism. Psychoneuroendocrinology. doi:pii: S0306‐
4530(13)00115‐7.10.1016/j.psyneuen.2013.03.020 THARINE DAL‐CIM, FABIANA K. LUDKA, WAGNER C. MARTINS, CHARLISE REGINATO, ESTHER PARADA, JAVIER EGEA, MANUELA G. LÓPEZ, CARLA I. TASCA. Guanosine controls inflammatory pathways to afford neuroprotection of hippocampal slices under oxygen and glucose deprivation conditions. Journal of Neurochemistry 126(4):437‐50. 2013. doi: 10.1111/jnc.12324 LORRIO S, ROMERO A, GONZÁLEZ‐LAFUENTE L, LAJARÍN‐CUESTA R, MARTÍNEZ‐SANZ FJ, ESTRADA M, SAMADI A, MARCO‐CONTELLES J, RODRÍGUEZ‐FRANCO MI, VILLARROYA M, LÓPEZ MG, DE LOS RÍOS C. PP2A ligand ITH12246 protects against 6 Manuela G. López memory impairment and focal cerebral ischemia in mice. ACS Chem Neurosci. 4(9):1267‐1277. 2013. 2014 PARADA E, BUENDIA I, LEÓN R, NEGREDO P, ROMERO A, CUADRADO A, LÓPEZ MG, EGEA J. Neuroprotective effect of melatonin against ischemia is partially mediated by alfa‐7 nicotinic receptor modulation and HO‐1 overexpression J Pineal Res. 56(2):204‐12. 2014. EGEA J, PARADA E, GÓMEZ‐RANGEL V, BUENDIA I, NEGREDO P, MONTELL E, RUHÍ R, VERGÉS J, RODA JM, GARCÍA AG, LÓPEZ MG. Small synthetic hyaluronan disaccharides afford neuroprotection in brain ischemia‐related models. Neuroscience. 265:313‐322. 2014. ANA I. ROJO, GETHIN MACBEAN, MARINA CINDRIC, JAVIER EGEA, MANUELA G. LÓPEZ, PATRICIA RADA, NEVEN ZARKOVIC AND ANTONIO CUADRADO. Redox control of microglial function: molecular mechanisms and functional significance. Antioxidants & Redox Signaling. doi: 10.1089/ars.2013.5745 JAVIER EGEA, ALEJANDRO ROMERO , ESTHER PARADA, RAFAEL LÉON, THARINE DAL‐
CIM AND MANUELA G. LOPEZ. Neuroprotective effect of dimebon against ischemic neuronal damage. Neuroscience. 267: 11‐21. 2014. B. LÓPEZ‐IGLESIAS, C. PÉREZ, J.A. MORALES‐GARCÍA, S. ALONSO‐GIL, A. PÉREZ‐
CASTILLO, D. H. CAIGNARD, A. ROMERO M. G. LÓPEZ, M. VILLARROYA, S. CONDE, AND M. I. RODRÍGUEZ‐FRANCO. New Neurogenic Melatonin – N,N‐Dibenzyl(N‐
methyl)amine Hybrids as Multifunctional Agents for the Potential Treatment of Alzheimer’s Disease, with Additional Cholinergic, Antioxidant, and Neuroprotective Properties. J. Med. Chem. 57:3773‐85. 2014 TENTI G, PARADA E, LEÓN R, EGEA J, MARTÍNEZ‐REVELLES S, BRIONES AM, SRIDHARAN V, LÓPEZ MG, RAMOS MT, MENÉNDEZ JC. New 5‐unsubstituted dihydropyridines with improved CaV1.3 selectivity as potential neuroprotective agents against ischemic injury. J. Med. Chem. PMID. 24754640 GONZÁLEZ‐MUÑOZ GC, ARCE MP, PÉREZ C, ROMERO A, VILLARROYA M, LÓPEZ MG, CONDE S, RODRÍGUEZ‐FRANCO MI. Dibenzo[1,4,5]thiadiazepine: A hardly‐known 7 Manuela G. López heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases. Eur J Med Chem. 81:350‐358. 2014 ROMERO A, EGEA J, GONZÁLEZ‐MUÑOZ GC, MARTÍN DE SAAVEDRA MD, DEL BARRIO L, RODRÍGUEZ‐FRANCO MI, CONDE S, LÓPEZ MG, VILLARROYA M, DE LOS RÍOS C ITH12410/SC058: A New Neuroprotective Compound with Potential in the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2014 (PMID: 25008046) FREITAS AE, EGEA J, BUENDÍA I, NAVARRO E, RADA P, CUADRADO A, RODRIGUES AL, LÓPEZ MG. Agmatine Induces Nrf2 and Protects Against Corticosterone Effects in Hippocampal Neuronal Cell Line Mol Neurobiol. 2014 (PMID: 25084759) OUSSAMA CHERIF, FATIMA ALLOUCHE1, FAKHER, CHABCHOUB1, MOURAD CHIOUA, ELENA SORIANO, MATILDE YAÑEZ, RAMÓN CACABELOS, ALEJANDRO ROMERO, MANUELA G LÓPEZ, JOSE MARCO‐CONTELLES. Isoxazolotacrines as non‐toxic and selective butyrylcholinesterase inhibitors for Alzheimer’s disease. Future Med Chem. 6:1883‐1891. 2014 BALSERA B, MULET J, FERNÁNDEZ‐CARVAJAL A, DE LA TORRE‐MARTÍNEZ R, FERRER‐MONTIEL A, HERNÁNDEZ‐JIMÉNEZ JG, ESTÉVEZ‐HERRERA J, BORGES R, FREITAS AE, LÓPEZ MG, GARCÍA‐LÓPEZ MT, GONZÁLEZ‐MUÑIZ R, PÉREZ DE VEGA MJ, VALOR LM, SVOBODOVÁ L, SALA S, SALA F, CRIADO M. Chalcones as positive allosteric modulators of α7 nicotinic acetylcholine receptors: a new target for a privileged structure. Eur J Med Chem. 86:724‐
739. 2014 CUNHA MP, MARTÍN‐DE‐SAAVEDRA MD, ROMERO A, EGEA J, LUDKA FK, TASCA CI, FARINA M, RODRIGUES AL, LÓPEZ MG. Both creatine and its product phosphocreatine reduce oxidative stress and afford neuroprotection in an in vitro Parkinson's model. ASN Neuro. 2014 6(6). pii: 1759091414554945. doi: 10.1177/1759091414554945. 2015 EGEA J, BUENDIA I, PARADA E, NAVARRO E, RADA P, CUADRADO A, LÓPEZ MG, GARCÍA AG, LEÓN R. The melatonin‐sulforaphane hybrid ITH12674 affords neuroprotection in oxidative stress conditions by a "Drug ‐ Prodrug" mechanism of action. Br J Pharmacol. 172:1807‐1821. 2015. 8 Manuela G. López BUENDIA I, EGEA J, PARADA E, NAVARRO E, LEÓN R, RODRÍGUEZ‐FRANCO MI, LÓPEZ MG. The melatonin‐N,N‐dibenzyl(N‐methyl)amine hybrid ITH91/IQM157 affords neuroprotection in an in vitro Alzheimer´s model via Hemo‐oxygenase‐1 induction. ACS Chem Neurosci. 6:288‐26. 2015. CUNHA, M. P., PAZINI, F. L., LUDKA, F. K., ROSA, J. M., OLIVEIRA, A., BUDNI, J., RAMOS‐HRYB, A. B., LIEBERKNECHT, V., BETTIO, L. E., MARTIN‐DE‐SAAVEDRA, M. D., LOPEZ, M. G., TASCA, C. I., RODRIGUES, A. L. S. The modulation of NMDA receptors and L‐arginine/nitric oxide pathway is implicated in the anti‐immobility effect of creatine in the tail suspension test. Amino acids 47 795‐811. 2015. BENCHEKROUN M, BARTOLINI M, EGEA J, ROMERO A, SORIANO E, PUDLO M, LUZET V, ANDRISANO V, JIMENO ML, LÓPEZ MG, WEHLE S, GHARBI T, REFOUVELET B, DE ANDRÉS L, HERRERA‐AROZAMENA C, MONTI B, BOLOGNESI ML, RODRÍGUEZ‐FRANCO MI, DECKER M, MARCO‐CONTELLES J, ISMAILI L. Novel Tacrine‐Grafted Ugi Adducts as Multipotent Anti‐Alzheimer Drugs: A Synthetic Renewal in Tacrine‐Ferulic Acid Hybrids ChemMedChem. doi: 10.1002/cmdc.201402409. A J. MORENO‐ORTEGA, M. GUERRA‐ÁLVAREZ, E. NAVARRO, JC FERNÁNDEZ‐MORALES, MANUELA G. LÓPEZ* AND MARÍA F. CANO‐ABADEnhanced Ca2+ entry through α7 nicotinic receptors impairs neuronal viability through an endoplasmic reticulum Ca2+ deregulation J. Neurochem. 133:309‐19. 2015. A.E. FREITAS, J. EGEA I. BUENDIA, V. GÓMEZ‐RANGEL, E. PARADA, E. NAVARRO, A. I. CASAS, A. WOJNICZ, J. AVENDAÑO, A. CUADRADO, A. RUIZ‐NUÑO, A.LS. RODRIGUES, M.G. LOPEZ Agmatine, by improving neuroplasticity markers and inducing Nrf2, prevents corticosterone‐induced depressive‐like behavior in mice. Molecular Neurobiology DOI: 10.1007/s12035‐015‐9182‐6 PARADA E, BUENDIA I., NAVARRO E., LEÓN R., AVENDAÑO C, EGEA J. AND LÓPEZ MG. Microglial HO‐1 induction by curcumin provides antioxidant, anti‐neuroinflammatory and glioprotective effects. Molecular Nutrition &Food Research 59:1690‐1700. 2015. 9 Manuela G. López BUENDIA I, PARADA E, NAVARRO E, LEÓN R, NEGREDO P, EGEA J. AND LÓPEZ MG. Subthreshold concentrations of melatonin and galantamine improves pathological AD hallmarks in hippocampal organotypic cultures. Molecular Neurobiology DOI: 10.1007/s12035‐015‐9272‐5 IZASKUN BUENDIA, VANESSA GÓMEZ‐RANGEL, LAURA GONZÁLEZ‐LAFUENTE, ESTHER PARADA, RAFAEL LEÓN, ISABEL GAMEIRO, PATRYCJA MICHALSKA, MOSHE LAUDON, JAVIER EGEA, AND MANUELA G. LÓPEZ. Neuroprotective mechanism of the novel melatonin derivative Neu‐P11 in brain ischemia related models. Neuropharmacology 99: 187‐195. 2015. JAVIER EGEA; IZASKUN BUENDIA; ESTHER PARADA; ELISA NAVARRO; RAFAEL LEON; MANUELA G. LOPEZ. Anti‐inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection. Biochemical Pharmacology doi: 10.1016/j.bcp.2015.07.032. ELISA NAVARRO, IZASKUN BUENDIA, ESTHER PARADA, RAFAEL LEÓN, PIDDER JANSEN‐DUERR, HAYMO PIRCHER, JAVIER EGEA AND MANUELA G. LOPEZ. Alpha7 nicotinic receptor activation protects against oxidative stress via heme‐oxygenase I induction. Biochemical Pharmacology 97. 473‐481. 2015. ANA JOSÉ MORENO‐ORTEGA, IZASKUN BUENDIA, LAMIA MOUHID, JAVIER EGEA, SUSANA LUCEA, ANA RUIZ‐NUÑO, MANUELA G. LÓPEZ AND MARÍA F. CANO‐ABAD CALHM1 and its polymorphism P86L differentially control Ca2+ homeostasis, mitogen activated protein kinase signalling and cell vulnerability upon exposure to amyloid β. Aging Cell. 14:1094‐1102. 2015. I. BUENDIA, E. NAVARRO, P. MICHALSKA, I. GAMEIRO, J. EGEA, S. ABRIL, A. LÓPEZ, L. GONZÁLEZ‐LAFUENTE, M. G. LÓPEZ AND R. LEÓN. New melatonin‐cinnamate hybrids as multitarget drugs for neurodegenerative diseases: Nrf2‐induction, antioxidant effect and neuroprotection. Future Medicinal Chemistry 7:1961‐1969. 2015. CASAS, A.I., DAO, V.T.‐V., DAIBER, A., MAGHZAL, G.J., DI LISA, F., KALUDERCIC, N., LEACH, S., CUADRADO, A., JAQUET, V., SEREDENINA, T., KRAUSE, K.H., LÓPEZ, M.G., STOCKER, R., GHEZZI, P., SCHMIDT, H.H.H.W. Reactive Oxygen‐Related Diseases: 10 Manuela G. López Therapeutic Targets and Emerging Clinical Indications. Antioxidants and Redox Signaling, 23:1171‐1185. 2015. 2016 ZHA, XIAOMING; LAMBA, DORIANO; ZHANG, LILI; LOU, YINGHAN; XU, CHANGXU; KANG, DI; CHEN, LI; XU, YUNGEN; ZHANG, LUYONG; DE SIMONE, ANGELA; SAMEZ, SARA; PESARESI, ALESSANDRO; STOJAN, JURE; LÓPEZ, MANUELA; EGEA, JAVIER; ANDRISANO, VINCENZA; BARTOLINI, MANUELA. Novel Tacrine‐Benzofuran Hybrids as Potent Multitarget‐Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation and X‐ray Crystallography. J. Med. Chem. 59:114‐311. 216. doi: 10.1021/acs.jmedchem.5b01119. 11