docAlfonso Barreto - Universitas Scientiarum
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Alfonso Barreto - Universitas Scientiarum
Departament of Microbiology Last Papers Alfonso Barreto Prieto, Biol., M.Sc., Ph.D. Grupo de Inmunobiología y Biología Celular Facultad de Ciencias E-‐mail: [email protected] Research Interest My research is focus in the study of primary mechanisms associated with modulation of immune response. Particularly, I have been studied those related to the generation of immune danger signals produced during virus infection or tumor progression. Different danger signals have been studied like the expression and release of heat shock proteins and extracellular vesicles production (exosomes or apoptotic bodies). I have been characterized these different extracellular vesicles throughout proteomics approximation. Actually, I am studying different kind of tumor cellular stress that could be associated with autophagy during cellular death, seeking for different danger signals which would finally produce or improve the quality of the immune response against tumor. Cell biology techniques like confocal microscopy, flow cytometry, ELISA or western blot are used to search such mechanisms. Velez J, Enciso LJ, Suarez M, et al., (2014). Platelets promote mitocondrial uncopling and resistance to apoptosis in leukemia cells: a novel paradigm for the bone marrow microenvironment. Cancer Microenvironment. IN PRESS Barreto A, Rodríguez LS, Rojas OL, et al., (2010). Membrane vesicles released by intestinal epithelial cells infected with rotavirus inhibit T-‐cell function. Viral Immunol. 23(6):595-‐608. Rodriguez, LS., Barreto, A., Franco, MA., et al., (2009). Immunomodulators Released During Rotavirus Infection of Polarized Caco-‐2 Cells. Viral Immunology 22 (3): 163-‐172. Fiorentino S, Barreto A, Asea A. (2007). Proteínas de choque térmico, muerte celular y respuesta antitumoral. Universitas Scientiarum 12:5-‐22. Fiorentino, S., Barreto, A., Castañeda, D., et al., (2007). Anti-‐tumor response and heat shock proteins (HSP): A friend o r foe relationship?. Chapter 20 in: Heat Shock Porteins: potent mediators of inflammation and immunity. Editors: Asea, A, De Maio, A. Springer. Bello F, Muñoz-‐Camargo, C, Barreto, A . (2005). Análisis de la susceptibilidad de una línea celular de Aedes aegypti (Diptera: Culicidae) a la infección con Leishmania (L) chagasi y Leishmania (V) braziliensis. Revista Ciencias de la Salud. Universidad del Rosario 3: 119-‐128. Espejo, J., Sosa, A., Carrascal, A.K., (2004). Producción de la proteína recombianante humana Hsc70 y su aplicación en el desarrollo de un sistema de detcción por ELISA. Universitas Scientiarium 9:69-‐80. Barreto, A., Gonzalez, J.M. Kabingu, E., et al., (2003). Stress-‐induced release of Hsc70 from human tumors. Cellular Immunology 222:97-‐104. Barreto, A. Villamil, L.A., Campo, H., et al., (1996). Infección in vitro de células del tipo endotelial. Revista de Medicina Veterinaria y Zootecnia XLIV (1):28-‐32. Research Lines Modulation mechanisms of immune response Chemoprevention and antitumor biomedicaments or immunoregulators
